MicroPET-MR scanner for preclinical molecular imaging

用于临床前分子成像的 MicroPET-MR 扫描仪

• 批准号: 8639739
• 负责人: Umar Mahmood
• 金额: $ 59.9万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2016-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639739
• 关键词: Algorithms; Anatomy; Animals; Area; Back; Boston; Brain; Chemistry; Communities; Complement; Data Collection; Development; Devices; Discipline; Discipline of Nuclear Medicine; Disease; Ensure; Evaluation; Funding; Funding Agency; General Hospitals; Genetically Engineered Mouse; Human; Image; Kinetics; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Massachusetts; Measures; Modality; Modeling; Molecular; Multimodal Imaging; Mus; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neurology; Organ; Positron-Emission Tomography; Radiochemistry; Radiology Specialty; Rattus; Request for Proposals; Research; Research Personnel; Research Support; Resolution; Rodent; Slice; Stem cells; System; Testing; Therapeutic; Tissue Engineering; Tracer; United States; United States National Institutes of Health; base; design; graphical user interface; image reconstruction; improved; instrumentation; millimeter; molecular imaging; mouse model; multimodality; novel; oncology; pre-clinical; radiotracer; receptor; reconstruction; response; uptake

DESCRIPTION (provided by applicant): This proposal requests funding for the purchase of a Super Argus Positron Emission Tomography-Magnetic Resonance (PET-MR) imaging system made by Sedecal Inc. for preclinical small animal multimodal imaging to support the research efforts in the Department of Radiology at the Massachusetts General Hospital (MGH). The device is the first commercial preclinical microPET-MR system available in the United States, and has fully integrated state-of-the-art high-resolution PET and state-of-the-art high-resolution MR capabilities. The system transaxial field of view is 68 mm for both components allowing both mouse and rat imaging. The PET acquisition has sub-millimeter spatial resolution, the highest sensitivity per slice of any commercial system, and high uniformity. Optimized algorithms result in rapid reconstruction of less than 2 min for 3D OSEM and less than 5 sec for filtered back projection. The MR acquisition module is based on a novel cryogen-free design, superconducting 3T magnet, with magnetic gradient strength of 125mT/m. The system has an integrated graphical user interface for both PET and MR acquisitions. This scanner will significantly enhance the research efforts of a diverse group of NIH funded investigators. The system will provide high-resolution multimodal imaging capabilities for non-invasive serial evaluation of MR agent and PET radiotracer distribution to facilitate research in new multimodal molecular tracers; provide high resolution correlative anatomic MR images for early assessment of response to novel therapies evaluated with changes in radiotracer uptake measured at the sub-organ level; and provide a platform for testing novel multimodality kinetic modeling and improved image reconstruction algorithms. The system has three major advantages over separate PET and MR devices for rodent imaging. First, the combined device can achieve temporal resolution for both modalities not attainable if animals are required to be moved between imaging systems; this is vital for both multimodal agent development and multimodal kinetic modeling. Second, spatial co-localization is greatly improved with a combined system, which is vital for brain receptor studies and assessment of genetically engineered mouse models of disease. Third, throughput is greatly enhanced without the need to move animals between systems, improving data collection. The application contains projects that comprise a broad base of users representing various disciplines (radiology/nuclear medicine, chemistry/radiochemistry, oncology, neurology, genetically engineered mouse modeling, kinetic modeling, image reconstruction, therapeutic stem cell delivery, and tissue engineering) and NIH funding sources (NCI, NIBIB, NHLBI, NINDS, NIDA, NIMH, NIAMS).The necessary administrative and technical direction is already in place to ensure efficient utilization of this instrumentation. This will be the first such system, commercial or otherwise, in the greater Boston area. It will provide a platform to test developed agents and imaging paradigms that will complement the human PET-MR efforts at MGH, and will be major asset to a large community of NIH funded investigators in the region.

描述（由申请人提供）：本提案要求为购买Sedecal Inc.制造的Super Argus正电子发射断层扫描-磁共振（PET-MR）成像系统提供资金。用于临床前小动物多模态成像，以支持马萨诸塞州总医院（MGH）放射科的研究工作。该设备是美国第一个商用临床前microPET-MR系统，完全集成了最先进的高分辨率PET和最先进的高分辨率MR功能。两种组件的系统轴向视野均为68 mm，可进行小鼠和大鼠成像。PET采集具有亚毫米空间分辨率、任何商业系统中每切片的最高灵敏度和高均匀性。优化的算法导致3D OSEM的快速重建不到2分钟，滤波反投影的快速重建不到5秒。MR采集模块基于新型无冷冻剂设计，超导3 T磁体，磁梯度强度为125 mT/m。该系统具有用于PET和MR采集的集成图形用户界面。这种扫描仪将大大提高NIH资助的研究人员的研究工作。该系统将提供高分辨率多模态成像能力，用于MR试剂和PET放射性示踪剂分布的非侵入性系列评价，以促进新的多模态分子示踪剂的研究;提供高分辨率相关解剖MR图像，用于早期评估对新疗法的反应，并通过在亚器官水平测量的放射性示踪剂摄取变化进行评估;并提供用于测试新颖的多模态动力学建模和改进的图像重建算法的平台。与单独的PET和MR设备相比，该系统在啮齿动物成像方面具有三大优势。首先，如果需要在成像系统之间移动动物，则组合设备可以实现两种模态的时间分辨率;这对于多模态代理开发和多模态动力学建模都是至关重要的。第二，空间共定位大大提高了与组合系统，这是至关重要的脑受体研究和评估基因工程小鼠模型的疾病。第三，不需要在系统之间移动动物，大大提高了吞吐量，改善了数据收集。该应用程序包含由代表各个学科的广泛用户组成的项目（放射学/核医学、化学/放射化学、肿瘤学、神经学、基因工程小鼠建模、动力学建模、图像重建、治疗性干细胞递送和组织工程）和NIH资金来源（NCI、NIBIB、NHLBI、NINDS、NIDA、NIMH、NIAMS）。这将是大波士顿地区第一个这样的系统，无论是商业的还是其他的。它将提供一个平台来测试开发的药物和成像范例，这将补充MGH的人类PET-MR工作，并将成为该地区NIH资助的大型研究人员社区的主要资产。