Dental and Craniofacial Effects of Intrauterine Zika Virus Infection

项目摘要/摘要： 寨卡病毒已被证明会影响胎儿的发育。到目前为止，直接联系 宫内寨卡病毒感染和严重的先天畸形，如小头畸形， 已被公认为世界范围内的突发公共卫生事件。尽管有多个国际组织 尽管作出了努力，但在科学知识状况方面仍有很大差距。 不同孕期宫内寨卡病毒感染的影响考虑到 病毒的传播不需要媒介传播，需要了解 宫内寨卡病毒暴露对胎儿发育的影响至关重要。因果作用的证据 先天性寨卡病毒感染的原因是明确的，因为该病毒已在 受影响的胎儿。鉴于波多黎各30%的孕妇可能没有症状 寨卡病毒感染。对于这些妇女所生的胎儿，我们不知道实际的影响速度 病毒对胎儿颅面和牙齿发育的影响。不断加深的理解 关于先天性寨卡病毒，指出了一系列的异常，但对颅面部和 牙齿发育仍未确定。我们也不知道其他情况可能会发生什么变化 寨卡病毒的毒性。有强有力的证据表明，产妇的口腔健康状况 与不良妊娠结局有关，但母体牙周病对 接触寨卡病毒的母亲的健康结果目前尚不清楚，也未被探索。的作用 母婴口腔健康在头面部表型和口腔运动中的其他方面 受寨卡病毒感染的妇女所生婴儿的功能需要进一步研究。这是我们的主要目标 母体寨卡病毒感染对头面部骨骼影响的研究 出生时有无小头畸形的婴儿的牙齿表型。临床、放射学和 3dMD面部表面成像技术将被用来开发一种广泛记录的 受影响婴儿样本的头面部表型；他们的评估将与 配对的对照组。来自口腔健康检查的数据和来自 产后12个月内的母亲和婴儿将被收集。这些数据将允许 检查可能影响病毒能力的口腔健康的相关方面 对婴儿造成不良影响。婴儿的口运动功能评估将是 在6个月和12个月内完成。调查结果将在颅面外科的成员之间进行讨论 团队盲法能够确定是否存在先天性寨卡病毒的影响 感染对颅面和牙齿发育的影响。

Project Summary/Abstract: Zika has been demonstrated to affect the development of the fetus. To date, a direct association between intrauterine Zika infection and severe congenital malformations, such as microcephaly, has been recognized as a public health emergency worldwide. In spite of multiple international efforts, there is still a significant gap in the state of scientific knowledge regarding the extent of the effects of intrauterine Zika exposure at different periods of gestation. Given that transmission of the virus does not require vector transmission, the need to understand the effects of intrauterine Zika exposure on fetal development is critical. Evidence of the causal role of congenintal Zika virus infection is clear as the virus has been identified in the brains of affected fetuses. Given that 30% of pregnant women in Puerto Rico may have asymptomatic Zika virus infections. For fetus’ born to these women, we do not know that actual rate of impact of the virus on fetal craniofacial and dental development. The increasing understanding regarding congenital Zika point to a range of anomalies, but the effects on craniofacial and dental development remains undefined. We also do not know what other conditions may alter the virulence of the Zika virus. There is strong evidence that maternal oral health status is associated to adverse pregnancy outcomes, but the role maternal periodontal disease on the health outcomes in Zika-exposed mothers is currently unknown and unexplored. The role of other aspects of maternal and infant oral health in the craniofacial phenotype and oromotor function of infants born to Zika-affected women requires further study. It is the main objective of this study to characterize the outcome of maternal Zika virus infection on craniofacial skeletal and dental phenotype in infants with or without microcephaly at birth. Clinical, radiographic and 3dMD Facial Surface Imaging techniques will be used to develop a vastly documented craniofacial phenotype of a sample of affected infants; their assessments will be compared to matched controls. Data from oral health examinations and biological samples from both the mother and the infant up to 12 months post-partum will be collected. These data will allow the examination of the concomitant aspects of oral health that may impact the capacity of the virus to cause an adverse effect in the infant. The infant’s oromotor function assessment will be completed at 6 and 12 months. Findings will be discussed among members of the craniofacial team in blinded fashion to be able to determine whether there is an effect of congenital Zika infection on craniofacial and dental development.