Dental and Craniofacial Effects of Intrauterine Zika Virus Infection

宫内寨卡病毒感染对牙齿和颅面的影响

• 批准号: 9381858
• 负责人: Maribel Campos-Rivera
• 金额: $ 25.19万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9381858
• 关键词: Address; Adverse effects; Affect; Age; Arbovirus Infections; Biological; Birth; Blinded; Brain; Caribbean region; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Clinical; Collaborations; Congenital Abnormality; Data; Dengue; Dental; Development; Diagnostic radiologic examination; Disease; Embryonic Development; Embryonic and Fetal Development; Epidemic; Evaluation; Exposure to; Face; Fetal Development; Fetus; Florida; Future; Goals; Health; Health Status; Imaging Techniques; Immune response; Individual; Infant; Infection; Interdisciplinary Study; International; Island; Knowledge; Light; Microcephaly; Mothers; Newborn Infant; Odontogenesis; Oral; Oral health; Outcome; Perinatal; Periodontal Diseases; Phenotype; Pilot Projects; Placenta; Play; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Principal Investigator; Protocols documentation; Puerto Rico; Reporting; Research Infrastructure; Risk; Role; Rubella; Sampling; Standardization; Surface; Surveillance Program; Testing; Three-Dimensional Imaging; Tissues; Tropical Climate; United States; Virulence; Virus; Virus Diseases; Woman; Zika Virus; adverse pregnancy outcome; antenatal; chikungunya; craniofacial; craniofacial development; fetal; imaging modality; insight; medical attention; member; oral pathogen; pregnant; programs; public health emergency; reproductive; response; skeletal; transmission process; vector transmission; viral transmission

Project Summary/Abstract: Zika has been demonstrated to affect the development of the fetus. To date, a direct association between intrauterine Zika infection and severe congenital malformations, such as microcephaly, has been recognized as a public health emergency worldwide. In spite of multiple international efforts, there is still a significant gap in the state of scientific knowledge regarding the extent of the effects of intrauterine Zika exposure at different periods of gestation. Given that transmission of the virus does not require vector transmission, the need to understand the effects of intrauterine Zika exposure on fetal development is critical. Evidence of the causal role of congenintal Zika virus infection is clear as the virus has been identified in the brains of affected fetuses. Given that 30% of pregnant women in Puerto Rico may have asymptomatic Zika virus infections. For fetus’ born to these women, we do not know that actual rate of impact of the virus on fetal craniofacial and dental development. The increasing understanding regarding congenital Zika point to a range of anomalies, but the effects on craniofacial and dental development remains undefined. We also do not know what other conditions may alter the virulence of the Zika virus. There is strong evidence that maternal oral health status is associated to adverse pregnancy outcomes, but the role maternal periodontal disease on the health outcomes in Zika-exposed mothers is currently unknown and unexplored. The role of other aspects of maternal and infant oral health in the craniofacial phenotype and oromotor function of infants born to Zika-affected women requires further study. It is the main objective of this study to characterize the outcome of maternal Zika virus infection on craniofacial skeletal and dental phenotype in infants with or without microcephaly at birth. Clinical, radiographic and 3dMD Facial Surface Imaging techniques will be used to develop a vastly documented craniofacial phenotype of a sample of affected infants; their assessments will be compared to matched controls. Data from oral health examinations and biological samples from both the mother and the infant up to 12 months post-partum will be collected. These data will allow the examination of the concomitant aspects of oral health that may impact the capacity of the virus to cause an adverse effect in the infant. The infant’s oromotor function assessment will be completed at 6 and 12 months. Findings will be discussed among members of the craniofacial team in blinded fashion to be able to determine whether there is an effect of congenital Zika infection on craniofacial and dental development.

项目概要/摘要： 寨卡病毒已被证明会影响胎儿发育。迄今为止， 宫内寨卡病毒感染与严重先天畸形，如小头畸形， 已被确认为全球范围内的公共卫生紧急事件。尽管国际上有多个 尽管作出了努力，但在科学知识方面， 在妊娠的不同时期，宫内寨卡病毒暴露的影响。鉴于 病毒的传播不需要媒介传播，需要了解 宫内寨卡病毒暴露对胎儿发育的影响至关重要。因果作用的证据 寨卡病毒感染的先天性是明确的，因为该病毒已被确定在大脑中， 影响胎儿。鉴于波多黎各30%的孕妇可能有无症状的 寨卡病毒感染对于这些妇女所生的胎儿，我们不知道实际的影响率 对胎儿颅面和牙齿发育的影响越来越多的理解 关于先天性寨卡指出了一系列异常，但对颅面和 牙齿发育仍不明确。我们也不知道还有什么其他条件会改变 寨卡病毒的危害有强有力的证据表明，母亲的口腔健康状况是 与不良妊娠结局相关，但母体牙周病对妊娠结局的作用 暴露于寨卡病毒的母亲的健康结果目前尚不清楚，也未经探索。的作用 在颅面表型和口腔发育方面母婴口腔健康的其他方面 受寨卡病毒感染的妇女所生婴儿的功能需要进一步研究。这是主要目标， 本研究旨在描述母体寨卡病毒感染对颅面骨骼的影响， 和牙齿表型在出生时有或没有小头畸形的婴儿。临床、影像学和 3dMD面部表面成像技术将用于开发大量记录的 受影响婴儿样本的颅面表型;他们的评估将与 匹配的控制。来自口腔健康检查和生物样本的数据， 将收集母亲和产后12个月内的婴儿。这些数据将使 检查可能影响病毒能力的口腔健康的伴随方面 对婴儿造成不良影响。婴儿的口腔功能评估将 在6个月和12个月时完成。调查结果将在颅面科学委员会成员之间进行讨论。 以盲态方式确定是否存在先天性寨卡病毒的影响 感染对颅面和牙齿发育的影响。