Core-009

核心009

• 批准号: 9387393
• 负责人: PEGGY J Farnham
• 金额: $ 64.91万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387393
• 关键词: Adult; Advanced Malignant Neoplasm; Budgets; Cancer Center; Catchment Area; Center Core Grants; Child; Childhood; Clinical Research; Collection; Colorectal; Communities; Ensure; Epidemiology; Fees; Formalin; Freezing; Funding; Grant; Health; Hodgkin Disease; Hospitals; Human; Informed Consent; Institutional Review Boards; Laboratories; Leadership; Malignant Neoplasms; Malignant neoplasm of lung; Methodology; Neuroblastoma; Normal tissue morphology; Paraffin Embedding; Pathology; Peer Review; Process; Reporting; Research; Research Personnel; Residual state; Resource Sharing; Resources; Science; Services; Stomach; Surveillance Program; Tissue Embedding; Tissue Procurements; Tissues; Tumor Tissue; USC/Norris Comprehensive Cancer Center and Hospital; Underserved Population; Vulnerable Populations; arm; base; carcinogenesis; innovation; member; population based; programs; repository

The Translational Pathology Core has been continuously under the leadership of Dr. Sue Ellen Martin since its founding in 1998. This NCI-funded Shared Resource provides a single point of access for Cancer Center members needing tissue procurement and banking services. The specific aims of the Core are to: 1) procure, bank, process, track, and distribute both fresh/frozen and formalin-fixed, paraffin embedded (FFPE) normal and tumor tissue biospecimens necessary for laboratory-based, epidemiological, and hospital-based clinical studies being conducted by USC Norris Cancer Center members; 2) procure, maintain, and track discarded FFPE tumor tissue blocks from local regional hospitals identified through the Cancer Surveillance Program (CSP) for the population-based LA Residual Tissue Repository (RTR), which corresponds directly to the catchment area; 3) ensure that all studies utilizing tissue have appropriate documented IRB approval and that protected health information (PHI) is not released unless there is a signed written Informed Consent; and 4) incorporate innovations in tissue procurement and banking methodology to meet investigator-led research. The Core continues to have three components, or Arms: Adult, Pediatric and Population-Based. Together, these Arms provide an integrated, single stop service. Accomplishments during the project period include: 1) increased usage by Cancer Center members with peerreviewed grants. In the most recent reporting year (FY 2013-2014), 91 Cancer Center members used the Core, of which 53 (58%) had peer-reviewed funding. This is an increase of 140%, from the prior project period; 2) higher chargebacks. User fees account for 27% of the total budget, up from 17% over the project period; and 3) increased collection and distribution of both fresh/frozen and FFPE tissues. This has contributed to significant research advances by Cancer Center members in understanding of the mechanisms involved in carcinogenesis, particularly in gastric, colorectal, urothelial and lung cancers, neuroblastoma and Hodgkin’s lymphoma.

翻译病理学核心自成立以来一直由苏·艾伦·马丁博士领导