Development of Novel Ultra-short Echo Time - Magnetic Resonance Fingerprinting for the Assessment of Chronic Lung Disease

开发用于评估慢性肺病的新型超短回波时间磁共振指纹图谱

• 批准号: 9449267
• 负责人: Christian Edwin Anderson
• 金额: $ 4.95万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-17 至 2019-02-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9449267
• 关键词: Animal Model; Animals; Asthma; Bleomycin; Brain; Bronchoalveolar Lavage; Caring; Cause of Death; Chronic Bronchitis; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical; Clinical Research; Contrast Media; Cystic Fibrosis; Data; Detection; Development; Disease Progression; Dose; Early Intervention; Fibrosis; Fingerprint; Gases; Genetic; Health Care Costs; Healthcare Systems; Histologic; Hour; Human; Imaging Techniques; Imaging technology; In Vitro; Infection; Investigation; Ionizing radiation; Label; Lung; Lung diseases; Lung infections; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Medical; Methodology; Methods; Monitor; Mus; Noise; Patients; Perfusion; Predisposition; Protons; Pseudomonas aeruginosa; Pulmonary Emphysema; Pulmonary Fibrosis; Radial; Radiation; Regional Disease; Relaxation; Research; Resolution; Respiratory physiology; Roentgen Rays; Scanning; Signal Transduction; Spirometry; Structure; Structure of parenchyma of lung; Techniques; Technology; Three-Dimensional Image; Time; Translations; United States; Validation; Work; X-Ray Computed Tomography; clinical imaging; clinical translation; cohort; density; imaging capabilities; imaging platform; imaging study; imaging system; in vivo; lung imaging; magnetic field; mortality; mouse model; novel; novel therapeutics; pediatric patients; pre-clinical; pre-clinical research; prevent; pulmonary function decline; radiofrequency; success; tool; virtual

PROJECT SUMMARY / ABSTRACT Chronic lung disease is one of the leading causes of mortality in the U.S. placing a significant burden on the health care system (>$30 billion currently for COPD). Unfortunately, clinical measurements of lung disease lack sensitivity to early regional disease (spirometry), are invasive (bronchoalveolar lavage), or expose patients to high doses of radiation (computed tomography (CT)). Therefore, a new non-invasive way to safely measure regional lung disease is an important tool for the care and investigation of chronic lung disease. Quantitative MRI can provide sensitive measurements of lung disease in a non-invasive fashion without ionizing radiation. For example, MR specific parameters (T1, T2*) and perfusion measurements have been shown to be associated with chronic lung disease and declining pulmonary function. The success in clinical imaging of lung disease has created an opportunity to explore animal models of lung disease with quantitative MRI. One major barrier to application of current clinical techniques to preclinical research is the significantly smaller amount of signal available for quantification in mouse lungs due to the ~1000 fold increase in spatial resolution, low spin density in the lungs, and increased magnetic susceptibility on high-field MRI scanners. Overcoming this decrease in signal relies on high field (>7T) MRI systems, small radiofrequency coils for efficient signal detection, and multiple signal averages to provide accurate quantification. The result is impractically long scan times for in vivo quantification of multiple MRI parameters. Therefore, there are currently no methods able to provide multi-parametric MRI measurements in animal models of lung disease. The MRI research group at CWRU has developed a wholly new platform of imaging techniques termed Magnetic Resonance Fingerprinting (MRF, Nature 2013). In the initial clinical study MRF simultaneously mapped T1, T2, and M0 in a human brain in ~10 seconds. Prior work has recently extended the MRF methodology to high-field preclinical MRI scanners. In this project, the MRF methodology will be expanded by incorporating ultra-short echo time (UTE) strategies to provide simultaneous multi-parametric MRI quantification (T1, T2, M0) in the lungs of mice in ~1 hour. These UTE-MRF assessments will be validated in in vitro phantoms as well as in established mouse models of lung infection and pulmonary fibrosis. A validated method for making quantitative multi-parametric MRI measurements in mouse models of lung disease will create opportunities for additional studies in a variety of mouse models of lung disease as well as rapid clinical translation to studies in patients.

项目总结/摘要 慢性肺病是美国死亡率的主要原因之一， 医疗保健系统（目前用于COPD的费用超过300亿美元）。不幸的是，肺的临床测量 疾病对早期局部疾病（肺量测定法）缺乏敏感性，是侵入性的（支气管肺泡灌洗），或暴露于 患者接受高剂量辐射（计算机断层扫描（CT））。因此，一种新的非侵入性方法， 测量区域性肺疾病是慢性肺疾病的护理和调查的重要工具。 定量MRI可以以非侵入性方式提供肺部疾病的敏感测量， 电离辐射例如，MR特定参数（T1，T2*）和灌注测量已经被 与慢性肺病和肺功能下降有关。临床上的成功 肺部疾病的成像为探索肺部疾病的动物模型提供了机会， 核磁共振将当前临床技术应用于临床前研究的一个主要障碍是 小鼠肺中可用于定量的信号量较少，这是由于空间分辨率增加约1000倍。 分辨率，肺部低自旋密度，以及高场MRI扫描仪上增加的磁化率。 克服这种信号下降依赖于高场（> 7 T）MRI系统，用于测量的小型射频线圈， 有效的信号检测和多个信号平均值，以提供准确的量化。结果是 用于体内定量多个MRI参数的不切实际的长扫描时间。因此有 目前没有能够在肺病动物模型中提供多参数MRI测量的方法。 CWRU的MRI研究小组开发了一种全新的成像技术平台， 磁共振指纹（MRF，Nature 2013）。在初始临床研究中，同时使用MRF 在大约10秒内绘制出人脑中的T1、T2和M0。先前的工作最近扩展了MRF 高场临床前MRI扫描仪的方法。在本项目中，MRF方法将通过以下方式扩展 结合超短回波时间（UTE）策略，以提供同步多参数MRI 在约1小时内在小鼠的肺中进行定量（T1、T2、M0）。这些UTE-MRF评估将在 体外模型以及建立的肺部感染和肺纤维化小鼠模型。经验证的 在肺部疾病的小鼠模型中进行定量多参数MRI测量的方法将 为在各种肺部疾病的小鼠模型中进行额外的研究以及快速的临床研究创造了机会。 转化为患者研究。