Mucosal vaccine for influenza on inactivated virus and mannan

灭活病毒和甘露聚糖流感粘膜疫苗

• 批准号: nhmrc : 365240
• 负责人: A/Pr David Anderson
• 金额: $ 8.8万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mucosal-vaccine-influenza-virus-mannan/96469
• 关键词: Mucosal; vaccine; influenza; inactivated; virus

Influenza is a respiratory disease that causes significant morbidity and mortality worldwide. Current influenza vaccines are a preparation of three currently circulating inactivated influenza strains that induces an antibody response that can combat the virus and therefore infection. Despite the availability of a vaccine new approaches are needed to increase the activity, usage and distribution. To this end several approaches based on using additional agents to increase the immunogenicity and needle free delivery are being explored. We have a natural sugar based compound that can be used to increase the body's immunity to cancers and infectious agents such as bacteria and viruses. When these preparations are applied into the nostril of mice they generate antibody responses to the infectious agent in the lungs, gut, tears, saliva that can act as a barrier to infectious agents. We are incorporating an inactive flu virus with this natural sugar to investigate if it produces antibody that can protect mice and ferrets from the flu virus. This method will be first tried with the human flu virus and if successful will be tried with the bird flu virus. If the preparation can protect mice and ferrets from human or bird flu infection it could develop into a human vaccine against bird flu. Since it can be administered by the nose it will be widely used and can be used readily without qualified personnel in the case of a pandemic.

流感是一种呼吸道疾病，在世界范围内引起显著的发病率和死亡率。目前的流感疫苗是三种目前流行的灭活流感毒株的制剂，其诱导可以对抗病毒并因此感染的抗体应答。尽管有疫苗可用，但仍需要新的方法来增加疫苗的活性、使用和分发。为此，正在探索基于使用额外试剂以增加免疫原性和无针递送的几种方法。我们有一种天然的糖基化合物，可用于提高人体对癌症和细菌和病毒等传染病的免疫力。当这些制剂被应用到小鼠的腹部时，它们在肺、肠道、眼泪、唾液中产生对感染因子的抗体反应，这些抗体可以作为感染因子的屏障。我们正在将一种非活性流感病毒与这种天然糖结合，以研究它是否能产生抗体，保护小鼠和雪貂免受流感病毒的侵害。这种方法将首先用于人类流感病毒，如果成功，将用于禽流感病毒。如果这种制剂能够保护小鼠和雪貂免受人类或禽流感感染，它就可能发展成为人类对抗禽流感的疫苗。由于它可以通过鼻子给药，因此将被广泛使用，在大流行的情况下，无需合格人员即可轻松使用。