Development of a rapid, point of care test with high sensitivity for the diagnosis of sepsis based on detection of CD64

开发一种基于 CD64 检测的快速、高灵敏度的护理点测试，用于诊断脓毒症

• 批准号: nhmrc : GNT1157784
• 负责人: A/Pr David Anderson
• 金额: $ 73.72万
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-rapid-point-detection-cd64/1349243
• 关键词: Development; rapid; point; care; test

There is an urgent, unmet need for improved point of care (POC) tests for detection of sepsis, which affects > 30 million and kills >8 million people worldwide each year. We have developed a new method for analysis of CD64, a host biomarker that is up-regulated as part of the innate immune response in sepsis. This new method shows greatly improved sensitivity for detection of sepsis patients versus controls, and will form the basis for development of a simple, lateral-flow POC test for sepsis.

有一种迫切的、尚未得到满足的需求，即改进护理点(POC)测试以检测脓毒症，败血症每年影响全球3000万人，并导致800万人死亡。我们已经开发了一种分析CD64的新方法，CD64是一种宿主生物标志物，在脓毒症中作为先天性免疫反应的一部分上调。与对照组相比，这一新方法对检测脓毒症患者的灵敏度有了很大的提高，并将为开发一种简单的、侧向流动的脓毒症POC测试奠定基础。