Training in Developmental Biology, Stem Cells and Regeneration

发育生物学、干细胞和再生培训

• 批准号: 9278703
• 负责人: Gage D Crump
• 金额: $ 18.73万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278703
• 关键词: Developmental Biology; Natural regeneration; Stem cells; Training

This application is for renewal of a Predoctoral Training Program in Developmental Biology, Stem Cells, and Regeneration (DSR), which is administered at the University of Southern California (USC) Keck School of Medicine, in conjunction with affiliated faculty at the Children's Hospital Los Angeles. This training program leverages recent and dramatic growth in stem cell biology and regenerative medicine at USC, which is reflected in the creation of a new Department of Stem Cell Biology and Regenerative Medicine and a university-wide USC Stem Cell initiative that is investing large sums of money to recruit world leaders and promising junior faculty. Particular strengths of training-related research, which benefit from interactions with closely situated institutes and one of the largest public hospitals in the country, include skeletal biology, neural and sensory systems, kidney, digestive and metabolic organs, and cancer stem cells. The rationale of this training program is that cohesive, structured training in basic developmental and stem cell biology, coupled with training-grant-specific courses and activities that provide in-depth exposure to clinical problems, will best train the future generation of scientists in the field of regenerative medicine. A major strength of this training program is that it provides added value, in the form of clinical exposure, on top of a newly created DSR PhD program. In particular, each trainee is paired with a Clinical Co-Mentor, who guides the student in learning about the diseases to which their primary research relates. During the first four years of the training program, the ten funded trainees, plus an additional four trainees funded by the Dean's office, will have published 30 first-author manuscripts, received an NIH F31 fellowship, and won a number of honors and awards. The majority of trainees first enter USC through a Program in Biomedical and Biological Sciences (PIBBS) umbrella admissions program, which has seen a steady rise in the quality of its training-grant-eligible applicant pool. At the end of their first year, students join the lab of one of our 26 training faculty, matriculate in the DSR PhD program, and take an intensive summer core course in developmental and stem cell biology, followed by journal club and research presentation courses in their second year. Following a formal call for applications and external review, select students join the T32 training program in their second and sometimes third years, at which point they take a trainee-specific Clinical Perspective of Regenerative Medicine course and engage in a number of trainee-specific activities including an annual retreat, a student-led symposium, frequent interactions with their clinical co-mentor, and monthly lunch gatherings. The cohesive structure of this training program provides an extra level of clinical fluency that the trainees would not otherwise have obtained through the DSR program alone. By leveraging the unique clinical resources within the neighboring Los Angeles area with the recent growth in basic stem cell research at USC, this training program provides a focused educational experience for those promising young scientists who wish to make a future impact in regenerative medicine.

此申请是在发育生物学，干细胞， 再生（DSR），这是由南加州大学（USC）凯克学院管理的， 医学，与附属学院在儿童医院洛杉矶。这个培训项目 利用南加州大学最近在干细胞生物学和再生医学方面的巨大增长， 反映在创建一个新的干细胞生物学和再生医学系， 大学范围内的南加州大学干细胞计划，正在投入大量资金招募世界领导人， 很有前途的初级教员与培训有关的研究的特殊优势， 附近的研究所和该国最大的公立医院之一，包括骨骼生物学，神经 和感觉系统，肾脏，消化和代谢器官，以及癌症干细胞。这种做法的理由是， 培训计划是基础发育和干细胞生物学的有凝聚力的结构化培训， 与培训补助金具体的课程和活动，提供深入接触临床问题，将最好 培养再生医学领域的下一代科学家。这种训练的主要优点是 该计划是，它提供了附加值，在临床接触的形式，在一个新创建的DSR博士 程序.特别是，每个受训者都与临床合作导师配对，指导学生学习 他们的主要研究所涉及的疾病在培训计划的前四年， 10名受资助的受训人员，加上另外4名由院长办公室资助的受训人员，将出版30本 第一作者手稿，获得了NIH F31奖学金，并赢得了许多荣誉和奖项。的 大多数受训人员首先通过生物医学和生物科学计划（PIBBS）进入南加州大学 招生计划，该计划的培训补助金合格申请人的质量稳步上升。在 第一年结束时，学生加入我们26个培训教师之一的实验室，在DSR博士录取 计划，并采取密集的夏季核心课程，在发育和干细胞生物学，其次是 在第二年的期刊俱乐部和研究报告课程。在正式征集申请后， 和外部审查，选择学生参加T32培训计划在他们的第二年，有时第三年， 在这一点上，他们采取了培训特定的再生医学课程的临床观点，并从事 一些针对受训者的活动，包括年度务虚会、学生主导的研讨会、经常性的 与他们的临床共同导师的互动，以及每月的午餐聚会。本培训的内聚结构 该计划提供了一个额外的临床流利程度，否则受训者将无法获得通过 DSR计划。通过利用邻近洛杉矶地区的独特临床资源 随着南加州大学基础干细胞研究的最近增长，该培训计划提供了一个重点教育 为那些希望在再生医学领域产生未来影响的有前途的年轻科学家提供经验。