Protein Structure Laboratory

蛋白质结构实验室（PSL）的使命是为研究人员提供最先进的 仪器，设施和专业知识的蛋白质晶体学的各个方面。其中包括蛋白质 晶化X射线数据收集、数据分析、结构解析和细化、结构分析。 实验室工作人员提供建议和咨询，培训，为有经验的 晶体学家，以及从晶体生长到结构解决方案和细化的一系列服务， 为出版物和赠款申请准备材料。此外，PSL还提供培训， 学生，博士后和教师谁希望学习任何或所有方面的蛋白质结构测定。到 促进这一点，现代结晶方法，内部或同步加速器X射线衍射数据收集， 使用最新的晶体学软件。工作人员包括一名经验丰富的全职博士。 结晶学家斯科特洛弗尔博士，谁担任实验室主任，和研究助理， 协助结晶筛选和X射线衍射实验的样品制备。PSL是 位于堪萨斯大学结构生物学的其他核心服务实验室附近 中心大楼。在第二阶段，PSL与来自学术界的36名研究人员合作， 政府和工业机构。这导致交付了100多个结构， 到蛋白质数据库，26出版物和17赠款申请提交，其中PSL工作人员是 上市PSL将继续扩大合作者的基础，并提供高水平的设施和专业知识， 在COBRE-PSF的第三阶段进行培训。

The mission ofthe Protein Structure Laboratory (PSL) is to provide investigators with state-of-the-art instrumentation, facilities, and expertise for all aspects of protein crystallography. This includes protein crystallization. X-ray data collection, data analysis, structure solution and refinement, and structure analysis. Laboratory staff provides advice and consultation, training, access to facilities for experienced crystallographers, and a range of services from crystal growth to structure solution and refinement, and preparation of materials for publications and grant submissions. In addition, the PSL provides training to students, post-docs and faculty who wish to learn any or all aspects of protein structure determination. To facilitate this, modern crystallization methods, in-house or synchrotron X-ray diffraction data collection, and the most recent crystallographic software are utilized. The staff consists of one experienced full time Ph.D. crystallographer. Dr. Scott Lovell, who serves as the Director ofthe Laboratory, and a Research Assistant to assist with crystallization screening and sample preparation for X-ray diffraction experiments. The PSL is located in close proximity to other core service laboratories in the University of Kansas Structural Biology Center building. During Phase II, the PSL has collaborated with 36 investigators from academic, government and industrial institutions. This has resulted in more than 100 structures delivered, 64 deposited to the Protein Databank, 26 publications and 17 grant applications submitted in which the PSL staff were listed. The PSL will continue to expand the base of collaborators and provide high-level facilities, expertise and training during Phase III ofthe COBRE-PSF.