Glutamatergic compounds for treating drug addiction: Preclinical models

用于治疗药物成瘾的谷氨酸化合物：临床前模型

• 批准号: 9555587
• 负责人: Eliot Gardner
• 金额: $ 34.91万
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9555587
• 关键词: Addictive Behavior; Animal Model; Behavior; Biochemical; Biological Assay; Brain; Budgets; Chemicals; Collaborations; Cues; Drug Addiction; Drug Industry; Electrical Stimulation of the Brain; Exposure to; Glutamates; Goals; High Pressure Liquid Chromatography; Intravenous; Laboratory Animals; Literature; Mediating; Metabotropic Glutamate Receptors; Microdialysis; Neurotransmitters; Peer Review; Pharmaceutical Preparations; Polymerase Chain Reaction; Pre-Clinical Model; Proteins; Psychological reinforcement; Publications; RNA; Relapse; Reporting; Research; Research Project Grants; Reverse Transcription; Rewards; Role; Sampling; Self Administration; Stress; System; Techniques; Western Blotting; Work; addiction; craving; follow-up; in vivo; interest; pre-clinical; preference

Due to extremely severe cuts in budget and staffing, no progress was made on this research project during the reporting period. This is unfortunate, as this project had been - in previous years - one of our most productive research endeavors, resulting in a large number of publications in the peer-reviewed scientific literature. We are presently pursuing external research collaborations, especially with entities within the pharmaceutical industry, that may allow us to once again pursue this work and follow up on the promising findings that we had obtained in previous years on this project.

由于预算和人员编制的极大削减，本报告所述期间，这一研究项目没有取得任何进展。这是不幸的，因为该项目在前几年一直是我们最有成效的研究努力之一，导致在同行评议的科学文献中发表了大量文章。我们目前正在寻求外部研究合作，特别是与制药行业内的实体合作，这可能使我们能够再次开展这项工作，并跟进我们在前几年就这一项目获得的有希望的发现。

项目成果

N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.

• DOI: 10.1016/j.neuropharm.2009.06.016
• 发表时间: 2010-01
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Xi ZX;Kiyatkin M;Li X;Peng XQ;Wiggins A;Spiller K;Li J;Gardner EL
• 通讯作者: Gardner EL

Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats.

• DOI: 10.1111/j.1471-4159.2010.06851.x
• 发表时间: 2010-09-01
• 期刊: Journal of neurochemistry
• 影响因子: 4.7
• 作者: Li X;Li J;Gardner EL;Xi ZX
• 通讯作者: Xi ZX

Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism.

• DOI: 10.1038/npp.2008.236
• 发表时间: 2009-06
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

• DOI: 10.1111/j.1471-4159.2009.06478.x
• 发表时间: 2010-01
• 期刊: Journal of neurochemistry
• 影响因子: 4.7
• 作者: Xi ZX;Li X;Peng XQ;Li J;Chun L;Gardner EL;Thomas AG;Slusher BS;Ashby CR Jr
• 通讯作者: Ashby CR Jr

Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist.

全身给予 GYKI 52466（一种非竞争性 AMPA 受体拮抗剂）后，大鼠的可卡因服用和可卡因寻求行为保持稳定。

• DOI: 10.1016/j.neulet.2011.12.028
• 发表时间: 2012
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Srivastava,Ratika;Xi,Zheng-Xiong;Gardner,EliotL
• 通讯作者: Gardner,EliotL