Scientific Core C Mouse Resources

摘要 核心C是鼠标资源核心。这三个项目都将广泛使用转基因小鼠 他们提议的实验。核心C的目的是提供动物的集中定位， 共享共同的育种种群，以及统一的基因型分析，这将 最大化效率并最小化与小鼠的生产和维护相关的成本 所需的实验。核心C的具体活动包括：（1）协助 新的转基因小鼠模型的产生;（2）育种的建立和维持 （3）定时妊娠的产生;（4）出生后实验动物的产生;（5）分娩 将实验动物运送到适当的实验室使用;（6）分发转基因小鼠 模型核心C人员在所提供服务的各个方面都受过良好的培训。鉴于沉重的 对转基因动物的依赖和核心人员的可靠表现， 核心C对计划项目补助金申请成功的重要性怎么强调都不过分。 相关性 这个鼠标资源核心对这三个项目的主要好处是促进新的 动物模型和有效利用现有的人类疾病的动物模型，从而加速基本的 的发现这一核心对社会的好处是最大限度地提高效率，最大限度地减少与之相关的成本。 使用人类疾病的动物模型。

ABSTRACT Core C is the Mouse Resources Core. All three Projects will make extensive use of genetically modified mice for their proposed experiments. The purpose of Core C is to provide a centralized localization of the animals, sharing of common breeding stocks, and uniform performance of genotype analyses, which will maximize efficiency and minimize costs associated with the production and maintenance of the mice needed for the proposed experiments. Specific activities of the Core C include (1) assistance in the generation of new genetically modified mouse models; (2) establishment and maintenance of breeding stocks; (3) generation of timed pregnancies; (4) generation of postnatal experimental animals; (5) delivery of experimental animals to the appropriate laboratory for use; (6) distribution of genetically modified mouse models. Core C personnel are well-trained in all aspects of the services to be provided. Given the heavy reliance on genetically modified animals and the proven performance of the Core personnel, the importance of Core C to the success of the Program Project Grant application cannot be overstated. RELEVANCE The major benefit of this Mouse Resources Core to these three Projects is to facilitate development of new animal models and efficient usage of existing animal models of human disease thereby accelerating basic discovery. The benefit of this Core to society is to maximize efficiency and minimize the costs associated with usage of animal models of human disease.