Neuropathology Core

摘要- ARTFL LEFFTDS纵向FTLD：神经病理学核心 近年来，神经退行性疾病的病理学变得越来越令人兴奋和复杂。这 这一趋势与FTLD尤其相关，其组织病理学多种多样，但又密切相关 亚型ALLFTD神经病理学核心的总体目标是（1）加强研究， ALLFTD联盟和（2）促进整个神经退行性疾病的基于组织的FTLD研究 疾病研究社区。该核心将由威廉塞利博士，丹尼斯迪克森和伊恩麦肯齐， FTLD解剖学和病理学领域的顶尖专家。我们的目标是促进神经病理学评估， 收集ALLFTD参与者的标准化数据，跨研究中心收集标准化数据， 以及冷冻组织，用于分发给整个更广泛的研究团体中的合格研究人员。我们 将对FTLD-TDP亚型的评估者间可靠性进行试点研究，并纳入一种新的FTLD-TDP 模块，以实现标准化的数据收集。最后，我们将与ALLFTD研究人员合作， 其他核心和项目1和2将临床、遗传、成像和生物标志物数据与神经病理学联系起来 数据这些目标的成功完成将对ALLFTD的整体成功产生重大影响 财团

ABSTRACT – ARTFL LEFFTDS Longitudinal FTLD: NEUROPATHOLOGY CORE Neurodegenerative disease pathology has become increasingly exciting and complex in recent years. This trend is particularly relevant to FTLD, with its many diverse and yet closely inter-related histopathological subtypes. The overarching goals of the ALLFTD Neuropathology Core will be to (1) enhance research within the ALLFTD consortium and (2) promote tissue-based FTLD research throughout the neurodegenerative disease research community. The core will be led by Drs. William Seeley, Dennis Dickson, and Ian Mackenzie, leading experts in FTLD anatomy and pathology. We aim to facilitate neuropathologic assessments and standardized data collection on ALLFTD participants, collect standardized data across sites, and bank fixed and frozen tissues for distribution to qualified investigators throughout the broader research community. We will perform a pilot study of inter-rater reliability of FTLD-TDP subtypes, and incorporate a novel FTLD-TDP module to enable standardized data collection. Finally, we will collaborate with ALLFTD researchers in the other Cores and Projects 1 and 2 to link clinical, genetic, imaging, and biomarker data to neuropathological data. Successful completion of these goals will have a major impact on the overall success of the ALLFTD consortium.