Neuropathology Core

神经病理学核心

• 批准号: 10450022
• 负责人: WILLIAM W SEELEY
• 金额: $ 74.09万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450022
• 关键词: Alzheimer' s Disease; Anatomy; Autopsy; Biological; Biological Markers; Brain; Brain Diseases; British Columbia; C9ORF72; Classification; Clinic; Clinical; Collaborations; Communities; Complex; Consensus; Data; Data Collection; Databases; Diagnosis; Diagnostic; Differential Diagnosis; Disease; Drug or chemical Tissue Distribution; Enrollment; Equipment and supply inventories; Event; Financial Support; Freezing; Frontotemporal Lobar Degenerations; Future; Genes; Genetic; Goals; Human; Image; Leadership; Link; Location; Methods; Molecular; Mutation; Neuroanatomy; Neurodegenerative Disorders; Neurologist; Neurosciences; Participant; Pathogenicity; Pathologic; Pathology; Patients; Pilot Projects; Process; Proteins; Qualifying; Research; Research Personnel; Resources; Sampling; Seminal; Site; Specimen; Spinal Cord; Syndrome; Tissues; Universities; candidate validation; clinical research site; data management; data standards; design; immunoreactivity; interest; neuroimaging; neuropathology; novel; protein TDP-43; repository; success; tau Proteins; trend

ABSTRACT – ARTFL LEFFTDS Longitudinal FTLD: NEUROPATHOLOGY CORE Neurodegenerative disease pathology has become increasingly exciting and complex in recent years. This trend is particularly relevant to FTLD, with its many diverse and yet closely inter-related histopathological subtypes. The overarching goals of the ALLFTD Neuropathology Core will be to (1) enhance research within the ALLFTD consortium and (2) promote tissue-based FTLD research throughout the neurodegenerative disease research community. The core will be led by Drs. William Seeley, Dennis Dickson, and Ian Mackenzie, leading experts in FTLD anatomy and pathology. We aim to facilitate neuropathologic assessments and standardized data collection on ALLFTD participants, collect standardized data across sites, and bank fixed and frozen tissues for distribution to qualified investigators throughout the broader research community. We will perform a pilot study of inter-rater reliability of FTLD-TDP subtypes, and incorporate a novel FTLD-TDP module to enable standardized data collection. Finally, we will collaborate with ALLFTD researchers in the other Cores and Projects 1 and 2 to link clinical, genetic, imaging, and biomarker data to neuropathological data. Successful completion of these goals will have a major impact on the overall success of the ALLFTD consortium.

摘要-ARTFL LEFFTDS纵向FTLD：神经病理学核心 近年来，神经退行性疾病的病理学变得越来越令人兴奋和复杂。这 趋势与FTLD特别相关，其许多不同但密切相关的组织病理学 子类型。ALLFTD神经病理学核心的首要目标将是(1)在 ALLFTD联盟和(2)在整个神经退行性疾病中促进基于组织的FTLD研究 疾病研究社区。核心将由威廉·西利博士、丹尼斯·迪克森博士和伊恩·麦肯齐博士领导， FTLD解剖学和病理学领域的顶尖专家。我们的目标是促进神经病理评估和 对ALLFTD参与者进行标准化数据收集，跨站点收集标准化数据，并进行银行固定 和冷冻组织，以分发给更广泛的研究界的合格调查人员。我们 将对FTLD-TDP亚型的评分员间可靠性进行初步研究，并纳入一种新的FTLD-TDP 模块，以实现标准化数据收集。最后，我们将与ALLFTD的研究人员在 将临床、遗传、影像和生物标记物数据与神经病理学联系起来的其他核心和项目1和2 数据。这些目标的成功完成将对ALLFTD的总体成功产生重大影响 财团。