MacCHESS Synchrotron Source for Structural Biology
MacCHESS 结构生物学同步加速器源
基本信息
- 批准号:9805369
- 负责人:
- 金额:$ 598.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressBiologicalBiological ProcessBiological ProductsBiologyBiomedical ResearchCharacteristicsCollectionCommunitiesComplexComputer softwareCountryCrystallizationCrystallographyDataData CollectionDevelopmentDiffuseDiseaseEducation and OutreachEducational workshopEmerging TechnologiesEquipmentFundingFutureGene ExpressionGenerationsGoalsGovernmentGrowth Factor ReceptorsHuman ResourcesInstitutionIon ChannelKnowledgeLeadershipMacromolecular ComplexesMembraneMethodologyMethodsMissionMolecularMolecular ConformationMotionNeuronsNucleic AcidsPostdoctoral FellowProceduresProcessProteinsPublishingRNA SplicingReceptor SignalingRegulationReportingResearch PersonnelResolutionResourcesRoentgen RaysRoleRunningScheduleScienceScientistSeasonsServicesShapesSignaling ProteinSourceSpecial EquipmentStrategic PlanningStructural BiologistStructureStudentsSynchrotronsSystemTechniquesTechnologyTimeTrainingUnited States National Institutes of HealthVisitWorkbasebeamlineclinical developmentdesignenzyme mechanismexperienceexperimental studyflexibilityfrontierimprovedinsightinstrumentationinterestmacromolecular assemblymacromoleculemethod developmentnew technologynew therapeutic targetnoveloperationpressureprogramsprotein complexreceptorstructural biologysuccess
项目摘要
Project summary:
The MacCHESS Synchrotron Source for Structural Biology facilitates the utilization of both
established and emerging technologies to advance biomedical research goals. Work performed at
MacCHESS is expected to yield fundamentally important insights into biology and biomedicine, adding to
the understanding of complex membrane receptor-signaling systems, the regulation of ion channels in
neuronal function, catalytic mechanisms of enzymes, and the complex macromolecular assemblies
responsible for gene expression. Upgrades to CHESS, including improvements to the storage ring and
newly designed beamlines that will provide state-of-the-art facilities, will be in place by June 2019.
MacCHESS will continue to support more than 100 investigator projects, funded by NIH and other
government institutions, through two major Technology Operations Cores. These are: 1) Facility for
Flexible Crystallography. The Flexible Crystallography Technology Core will take advantage of unique
MacCHESS capabilities to enable the development of new X-ray techniques that may be used to broaden
knowledge of biological processes. Examples include continued development of methods for serial
crystallography, improvements in crystal handling techniques, the application of high pressure to crystals,
and analysis of macromolecular motions through the study of X-ray diffuse scattering. A high level of
support for more routine macromolecular crystallography will also be provided, to answer a range of
structural questions involving single proteins, nucleic acids, and macromolecular complexes, as well as to
provide valuable complementary information to the results obtained from the less standard types of
structural studies. 2) Facility for Biological Small Angle X-ray Scattering (BioSAXS). This technology
core will implement state-of-the-art hardware, software, and expertise to support the increasingly in-
demand BioSAXS technique. In addition to determining the shapes of proteins, nucleic acids, and larger
assemblies in solution, BioSAXS allows researchers to obtain information regarding global conformational
changes within macromolecular complexes (e.g. growth factor receptors, RNA-splicing complexes) and/or
the changes in their oligomeric states that have important functional consequences. This core will also
provide the necessary equipment and expertise for investigators interested in performing time-resolved
BioSAXS or BioSAXS studies conducted under high pressure. MacCHESS will provide a strong
Administration Core to support these activities and will continue to educate users, and the biomedical
research community, through a Training and Outreach Core. Collectively, these efforts will offer unique
opportunities to our users for pursuing some of the most challenging questions in structural biology and for
obtaining structure-function information that will ultimately highlight novel therapeutic targets and aid in the
development of clinical strategies for dealing with disease.
项目概要:
MacCHESS结构生物学同步加速器源促进了两者的利用
现有和新兴技术,以推进生物医学研究目标。工作地点
MacCHESS预计将产生对生物学和生物医学的重要见解,
复杂的膜受体信号系统的理解,离子通道的调节,
神经元功能,酶的催化机制,以及复杂的大分子组装
负责基因表达。升级国际象棋,包括改进储存环,
新设计的光束线将提供最先进的设施,将于2019年6月到位。
MacCHESS将继续支持100多个由NIH和其他机构资助的研究项目。
政府机构,通过两个主要的技术运营核心。(1)设施
柔性晶体学。柔性结晶技术核心将利用独特的
MacCHESS的能力,使新的X射线技术的发展,可用于扩大
了解生物过程。实例包括继续发展连续监测的方法,
晶体学,晶体处理技术的改进,高压对晶体的应用,
并通过X射线漫散射研究分析大分子运动。高水平的
还将提供更多常规大分子晶体学的支持,以回答一系列
涉及单个蛋白质、核酸和大分子复合物的结构问题,以及
提供有价值的补充信息,从不太标准的类型的结果,
结构研究。2)生物小角X射线散射装置(BioSAXS)。这项技术
核心将实施最先进的硬件、软件和专业知识,以支持日益增长的
需要BioSAXS技术。除了确定蛋白质、核酸和更大分子的形状外,
在溶液中组装,BioSAXS允许研究人员获得有关全局构象的信息,
大分子复合物(例如生长因子受体、RNA剪接复合物)内的变化和/或
它们的低聚状态的变化具有重要的功能性后果。该核心还将
为有兴趣进行时间分辨的调查人员提供必要的设备和专业知识。
在高压下进行的BioSAXS或BioSAXS研究。Macchess将提供强大的
管理核心支持这些活动,并将继续教育用户,生物医学
研究社区,通过培训和外联核心。总的来说,这些努力将提供独特的
为我们的用户提供了研究结构生物学中一些最具挑战性的问题的机会,并为
获得结构-功能信息,最终将突出新的治疗靶点,并有助于
制定应对疾病的临床策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RICHARD A. CERIONE的其他文献
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{{ truncateString('RICHARD A. CERIONE', 18)}}的其他基金
Probing the molecular mechanisms that regulate key steps in the GPCR-sensory response pathway responsible for vision in dim light
探索调节负责弱光视觉的 GPCR 感觉反应通路关键步骤的分子机制
- 批准号:
10635707 - 财政年份:2023
- 资助金额:
$ 598.58万 - 项目类别:
Targeting the dependency of cancer cells on the sirtuin SIRT5
靶向癌细胞对 Sirtuin SIRT5 的依赖性
- 批准号:
9895673 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
MacCHESS Synchrotron Source for Structural Biology
MacCHESS 结构生物学同步加速器源
- 批准号:
10231133 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
Targeting the dependency of cancer cells on the sirtuin SIRT5
靶向癌细胞对 Sirtuin SIRT5 的依赖性
- 批准号:
10261077 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
MacCHESS Synchrotron Source for Structural Biology
MacCHESS 结构生物学同步加速器源
- 批准号:
10582108 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
Targeting the dependency of cancer cells on the sirtuin SIRT5
靶向癌细胞对 Sirtuin SIRT5 的依赖性
- 批准号:
10369635 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
MacCHESS Synchrotron Source for Structural Biology
MacCHESS 结构生物学同步加速器源
- 批准号:
10443671 - 财政年份:2019
- 资助金额:
$ 598.58万 - 项目类别:
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