Novel ultra-fast photodetectors for near reconstruction-less time-of-flight positron emission tomography

用于近重建飞行时间正电子发射断层扫描的新型超快光电探测器

• 批准号: 9809409
• 负责人: Gerard Ariño Estrada
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9809409
• 关键词: 3-Dimensional; Bismuth; Bromides; Calibration; Cells; Cherry - dietary; Clinical; Coupled; Crystallization; Data; Detection; Development; Devices; Dimensions; Electrons; Evaluation; Gamma Rays; Germany; Goals; Image; Japan; Lead; Legal patent; Lesion; Light; Measures; Mentorship; Morphologic artifacts; Muslim religion; Noise; Penetration; Performance; Periodicity; Photons; Physiologic pulse; Positioning Attribute; Positron; Positron-Emission Tomography; Property; Radiation Dose Unit; Reaction Time; Resolution; Signal Transduction; Silicon; Structure; System; Technology; Testing; Thallium; Thick; Thinness; Time; Width; Work; absorption; attenuation; base; design; detector; experience; high reward; high risk; improved; innovation; novel; off-patent; optical communication; photomultiplier; photon-counting detector; photonics; prevent; prototype; quantum; radiation detector; reconstruction; response; tumor; ultraviolet

SUMMARY Time-of-Flight Positron Emission Tomography (TOF-PET) scanners provide better signal-to-noise ratio (SNR) and artifact reduction compared to conventional PET systems. The performance of TOF-PET scanners improves with the timing precision of its detectors: the more accuracy in the time detection of gamma photons the better the performance. The ultimate aim of TOF-PET is to reach a 10 ps full width at half maximum (FWHM) coincidence time resolution (CTR) to resolve precisely the positron-electron annihilation point in 3 dimensions. State-of-the-art PET detectors consist of scintillation crystals coupled to silicon photomultipliers (SiPM) and show timing resolutions in the order of 100-200 ps FWHM. In this project, we focus on improving dramatically the timing properties of the SiPMs, as such improvement would have a strong impact on TOF-PET as it would improve the timing performance of most detectors that use scintillation crystals and/or Cerenkov light emitters by several-fold. State-of-the-art SiPMs are optimized for a narrow range of wavelengths (λ) because of the difference in penetration depth at different wavelengths. For photons of λ=450 nm and λ=590 nm, the attenuation depth is 0.4 μm and 2 μm, respectively. The trade-off is to either a) to have a thicker depletion layer to absorb a wider range of wavelengths but to increase the time jitter, or b) to have a thinner depletion layer to reduce the time jitter but absorb only a narrow range of wavelengths. Therefore, there is not a state-of-the-art SiPM that provides, simultaneously, very fast time response, and high photon detection efficiency (PDE) across a wide range of wavelengths. We propose to develop an SiPM prototype with photon-trapping microstructures integrated in the depletion layer that disperses the light laterally and allows one to obtain high-detection efficiency for a wide range of wavelengths within a depletion layer of 1 μm. With such a thin layer, the jitter in the electron drift time decreases to 10 ps and the dark current is expected to decrease as well. This new photosensor could revolutionize TOF-PET. The utilization of periodic microstructures to bend light in a perpendicular orientation and trapping photons for enhanced interaction with materials, high detection efficiency and fast response have been recently shown for wavelengths between 800-900 nm for optical communication. In this proposal, we will develop a new SiPM based on this technology. First, we will simulate the optimum layer structure to integrate the hole-trapping microstructures and an avalanche region to provide a gain of >105. Second, we will do an electronic characterization for the different type of microcells, including a gain calibration and measure quantum efficiency for different λ for each cell. Finally, we will manufacture a wafer with full-size SiPMs (3x3 mm2) and test the SiPMs with scintillation crystals and Cerenkov emitters.

总结 飞行时间正电子发射断层扫描（TOF-PET）扫描仪提供更好的信噪比（SNR） 和伪影减少。TOF-PET扫描仪的性能得到改善 其探测器的定时精度：伽马光子的时间探测精度越高， 演出TOF-PET的最终目标是达到10 ps的半高宽（FWHM） 符合时间分辨率（CTR）可精确解析3维正电子-电子湮没点。 最先进的PET探测器由耦合到硅光电倍增管（SiPM）的闪烁晶体组成， 定时分辨率在100-200 ps FWHM的量级。 在这个项目中，我们专注于显著改善SiPM的时序特性， 将对TOF-PET产生强烈影响，因为它将改善大多数使用 闪烁晶体和/或切伦科夫光发射器。最先进的SiPM经过优化， 由于不同波长下的穿透深度不同，波长范围（λ）较窄。为 对于波长为450 nm和590 nm的光子，衰减深度分别为0.4 μm和2 μm。代价是 或者a）具有较厚的耗尽层以吸收较宽范围的波长但增加时间抖动， 或B）具有较薄的耗尽层以减小时间抖动但仅吸收窄范围的波长。 因此，不存在同时提供非常快的时间响应和高性能的最先进的SiPM。 在宽波长范围内的光子探测效率（PDE）。 我们建议开发一个光子捕获微结构集成在耗尽层的硅粉末冶金原型 其使光横向分散并允许人们获得宽波长范围的高检测效率 在1 μm的耗尽层内。利用这样的薄层，电子漂移时间中的抖动减小到10 ps， 预期暗电流也会减小。这种新的光电传感器可以彻底改变TOF-PET。 利用周期性微结构使光在垂直方向上弯曲并捕获光子， 与材料的增强的相互作用、高检测效率和快速响应最近已经被证明用于 波长在800-900 nm之间，用于光通信。在本提案中，我们将开发一种新的SiPM， on this technology技术.首先，我们将模拟最佳的层结构，以集成空穴捕获 微结构和雪崩区以提供>105的增益。第二，我们要做电子 不同类型的微单元的特性，包括增益校准和测量量子效率 对于每个单元的不同λ。最后，我们将制造具有全尺寸SiPM（3x 3 mm 2）的晶圆，并测试 具有闪烁晶体和切伦科夫发射器的SiPM。