课题基金 / 基金详情

Regulation of salivary gland inflammation in Sjogren's Syndrome by Annexin 1

Regulation of salivary gland inflammation in Sjogren's Syndrome by Annexin 1
膜联蛋白 1 对干燥综合征唾液腺炎症的调节
批准号:
9809545
负责人:
Markus Hardt
金额:
$24.88万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-07-01 至 2021-06-30

项目摘要

项目成果

Markus Hardt的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY This objective of this proposal is to examine the specific role of the anti-inflammatory and pro-resolving protein Annexin A1 (AnxA1) during the development and onset of Sjögren's Syndrome (SjS), the second most common rheumatic disease that primarily targets the salivary and lacrimal glands causing clinical dry eye and dry mouth symptoms. Pathophysiological events in SjS are strongly associated with aberrant proteolysis. The proposal hypothesizes that SjS-associated proteolytic processing alter the anti-inflammatory and pro-resolution properties of AnxA1. While loss of AnxA1 has been associated with uncontrolled proliferation and activation of autoreactive Th17 cells in the mouse model of experimental autoimmune uveitis, there is a critical knowledge gap about AnxA1 in the SjS disease process. In our preliminary studies, we discovered cleavage products of the N-terminal region of AnxA1 that harbors the main pharmacophore for the anti-inflammatory properties of AnxA1. Aim 1 will determine whether preventive treatment with N-terminal AnxA1 peptide ac2-26 will reduce inflammation, modulate T cell response and prevent salivary gland destruction in the NOD mouse model. Aim 2 will evaluate the effect of AnxA1-protective protease inhibitors on the development and onset of SjS in NOD mice. Results from this study will provide critical insights into the role of AnxA1 in modulating autoimmune response and promote resolution in SjS and suggest novel mechanism-derived strategies for diagnosis and controlling inflammation and tissue dysfunction and destruction in SjS.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The Role of Proteases and Peptides in Cancer Pain
  • 批准号:
    8141367
  • 项目类别:
  • 资助金额:
    $55.05万
  • 财政年份:
    2010
  • 负责人:
    Markus Hardt
  • 依托单位:
The Role of Proteases and Peptides in Cancer Pain
  • 批准号:
    8292511
  • 项目类别:
  • 资助金额:
    $37.07万
  • 财政年份:
    2010
  • 负责人:
    Markus Hardt
  • 依托单位:
The Role of Proteases and Peptides in Cancer Pain
  • 批准号:
    8319268
  • 项目类别:
  • 资助金额:
    $43.95万
  • 财政年份:
    2010
  • 负责人:
    Markus Hardt
  • 依托单位:
The Role of Proteases and Peptides in Cancer Pain
  • 批准号:
    8517250
  • 项目类别:
  • 资助金额:
    $4.24万
  • 财政年份:
    2010
  • 负责人:
    Markus Hardt
  • 依托单位:
国内基金
海外基金
靶向Annexin A1蛋白预防CAR-T细胞治疗后BCMA阴性多发性骨髓瘤复发的机制研究
  • 批准号:
    82370201
  • 项目类别:
    面上项目
  • 资助金额:
    48万元
  • 批准年份:
    2023
  • 负责人:
    许捷
  • 依托单位:
Annexin A1通过IFN-γ通路正向调控PD-L1介导肺腺癌免疫逃逸的机制研究
  • 批准号:
    82172716
  • 项目类别:
    面上项目
  • 资助金额:
    55万元
  • 批准年份:
    2021
  • 负责人:
    夏曙
  • 依托单位:
外源性尿酸调控SP1-Annexin a1在大鼠肝性脑病中的保护作用及机制研究
  • 批准号:
    82060128
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    34.0万元
  • 批准年份:
    2020
  • 负责人:
    程翅
  • 依托单位:
Annexin A1 调控 Notch1/Smad2/p15 信号轴促进急性髓系白血病细胞增殖的机制研究
  • 批准号:
    81770176
  • 项目类别:
    面上项目
  • 资助金额:
    55.0万元
  • 批准年份:
    2017
  • 负责人:
    付彩云
  • 依托单位: