A2CPS Genetic Variant Core
A2CPS 遗传变异核心
基本信息
- 批准号:9812621
- 负责人:
- 金额:$ 2.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAcute PainAdherenceBiological MarkersBlood specimenClinicalClinical DataCollaborationsCollectionCommunicationComplexDNADataData AnalysesData Coordinating CenterData SetDepositionDetectionDevelopmentEnsureGenerationsGeneticGenomic medicineGoalsHuman ResourcesIndividualInstitutesKnowledgeLongitudinal cohortMetadataMethodsMolecularMultiomic DataMusculoskeletalOperative Surgical ProceduresPainParticipantPatientsPersonsPhenotypePredispositionPrevention strategyProceduresProcessProtocols documentationQuality ControlReportingReproducibilityResearch DesignResearch PersonnelResistanceResourcesSamplingTraumaValidationVariantWorkanalysis pipelinebiomarker selectioncandidate markercandidate selectionchronic paindata integrationdata submissionexperiencegenetic associationgenetic predictorsgenetic selectiongenetic signaturegenetic variantimaging biomarkermeetingsnovelpersonalized strategiesprimary outcomeprogramspsychosocialrecruitresiliencesample collectionscreeningsexskills
项目摘要
GENETIC VARIANT CORE
SUMMARY
Chronic pain is a complex problem, likely influenced by multiple environmental and genetic factors. Growing
evidence for a genetic basis for developing chronic pain suggests it may be possible to use genetic predictors to
differentiate between patients likely to be susceptible versus resilient to the development of chronic pain. This
project is the Genetic Variant Core (GVC) of the Omics Data Generation Center (ODGC) for the Acute to Chronic
Pain Signatures (A2CPS) Program. In this Program, the Clinical Centers will recruit and collect clinical data and
biofluid samples from two longitudinal cohorts of 1800 subjects each. Biofluid samples will be collected 0, 3, and
6 months after an acute pain episode, consisting of a specific surgical procedure or a specific musculoskeletal
trauma. These samples will be used to generate multi-omic data to validate 40 primary outcome biomarkers
indicating susceptibility or resilience to development of chronic pain, as well as to identify new candidate
biomarkers. For the proposed Genetic Variant Core, Aim 1, which will be executed in Year 1, will involve close
collaboration with other components of the A2CPS Program to establish the final study design and protocols. All
of the A2CPS Program investigators will work together to establish the 40 primary outcome biomarkers. The
ODGC and Clinical Center investigators will jointly decide on the specific sample type(s) and
collection/processing/storage methods. The ODGC and Data integration Resource Center/Data Coordination
Component (DIRC/DCC) investigators will establish Metadata and Data Standards and a workflow for
submission of metadata and data to the DCC. The GVC and the Administrative Core of the ODGC will establish
an integrated LIMS for sample and data tracking, and recording of metadata. The GVC and DIRC/Data
Integration and Analysis Component (DIAC) will establish data analysis pipelines. Aims 2 and 3 will span Years
2-4, with Aim 2 focused on DNA isolation and genetic variant arrays for the 3600 participant samples that will be
collected by the Clinical Centers. Aim 3 will encompass submission of metadata and data to the DIRC/DCC,
quality control of the data, and data analysis and interpretation. The primary goal of this Component is generation
and submission of high-quality gene variant array data for the validation of pre-selected genetic variant
biomarkers. While the study is not powered to identify novel genetic associations, we expect to extend the
analysis beyond the jointly selected genetic variant biomarkers to include additional variants implicated in
susceptibility/resilience to chronic pain. GVC component investigators will participate in integrative analyses with
the DIRC/DIAC aimed at developing pain signatures comprised of multiple biomarker types (including molecular,
clinical, psychosocial, and/or imaging biomarkers) indicating susceptibility/resilience to chronic pain, which can
be used to develop personalized strategies for prevention and treatment of chronic pain. The personnel for this
proposed GVC have acquired the necessary skills and knowledge to successfully execute this project from
participation in multiple large-scale projects generating genetic variant array data.
遗传变异核心
概括
慢性疼痛是一个复杂的问题,可能受多种环境和遗传因素的影响。生长
建立慢性疼痛的遗传基础的证据表明,有可能将遗传预测因子用于
区分可能易感性与慢性疼痛发展的患者。这
项目是急性至慢性的OMIC数据生成中心(ODGC)的遗传变异核心(GVC)
疼痛签名(A2CPS)程序。在该计划中,临床中心将招募和收集临床数据,
来自1800名受试者的两个纵向人群的生物流体样品。生物流体样品将收集0、3和
急性疼痛发作后6个月,由特定的手术程序或特定的肌肉骨骼组成
创伤。这些样品将用于生成多摩尼克数据以验证40个主要结果生物标志物
表明对慢性疼痛发展的敏感性或韧性,并确定新候选人
生物标志物。对于拟议的遗传变体核心,AIM 1将在第1年执行,将涉及关闭
与A2CPS计划的其他组件合作,以建立最终的研究设计和协议。全部
在A2CPS计划中,调查人员将共同建立40个主要结果生物标志物。这
ODGC和临床中心研究人员将共同决定特定的样本类型和
收集/处理/存储方法。 ODGC和数据集成资源中心/数据协调
组件(DIRC/DCC)调查人员将建立元数据和数据标准以及工作流程
提交元数据和数据到DCC。 GVC和ODGC的行政核心将建立
用于样本和数据跟踪的集成LIM,以及元数据的记录。 GVC和DIRC/数据
集成和分析组件(DIAC)将建立数据分析管道。目标2和3将跨越几年
2-4,AIM 2专注于3600参与者样本的DNA隔离和遗传变异阵列
由临床中心收集。 AIM 3将包含元数据和数据提交给DIRC/DCC的数据
数据的质量控制以及数据分析和解释。该组件的主要目标是生成
并提交高质量基因变异阵列数据,以验证预选的遗传变异
生物标志物。虽然该研究没有能力识别新的遗传关联,但我们希望扩展
除了共同选择的遗传变异生物标志物以外的分析,包括与
对慢性疼痛的敏感性/韧性。 GVC组件研究人员将与
DIRC/DIAC旨在发展由多种生物标志物类型组成的疼痛特征(包括分子,
临床,社会心理和/或成像生物标志物)表明对慢性疼痛的敏感性/弹性,可以
用于制定预防和治疗慢性疼痛的个性化策略。这个人员
拟议的GVC已获得必要的技能和知识,以成功地执行该项目
参与生成遗传变异阵列数据的多个大型项目。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KELLY A FRAZER其他文献
KELLY A FRAZER的其他文献
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{{ truncateString('KELLY A FRAZER', 18)}}的其他基金
Genetic & Social Determinants of Health: Center for Admixture Science and Technology
遗传
- 批准号:
10818088 - 财政年份:2023
- 资助金额:
$ 2.22万 - 项目类别:
Genetic & Social Determinants of Health: Center for Admixture Science and Technology
遗传
- 批准号:
10307040 - 财政年份:2021
- 资助金额:
$ 2.22万 - 项目类别:
Genetic & Social Determinants of Health: Center for Admixture Science and Technology
遗传
- 批准号:
10492767 - 财政年份:2021
- 资助金额:
$ 2.22万 - 项目类别:
Genetic & Social Determinants of Health: Center for Admixture Science and Technology
遗传
- 批准号:
10599760 - 财政年份:2021
- 资助金额:
$ 2.22万 - 项目类别:
Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS) Program
急性至慢性疼痛特征 (A2CPS) 计划的组学数据生成中心 (ODGC)
- 批准号:
10199703 - 财政年份:2019
- 资助金额:
$ 2.22万 - 项目类别:
Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS) Program
急性至慢性疼痛特征 (A2CPS) 计划的组学数据生成中心 (ODGC)
- 批准号:
9812619 - 财政年份:2019
- 资助金额:
$ 2.22万 - 项目类别:
Optimizing HaploSeq for whole-genome phased haplotypes in biomedical applications
优化生物医学应用中全基因组定相单倍型的 HaploSeq
- 批准号:
8833411 - 财政年份:2015
- 资助金额:
$ 2.22万 - 项目类别:
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