Expansion of normative database for wide-band acoustic immittance measures to include children and abnormal ears and analyses of data across studies and underlying assumptions

项目摘要/摘要 这项工作旨在发展宽带声导抗(WAI)测量作为一种非侵入性听觉 诊断工具，其中WAI是指包括吸光度、功率等测量结果的集合 Refl电抗、阻抗和相关的量。这些措施的潜在用途包括(1)检测 鼓室导纳测量不太成功的新生儿和婴幼儿耳朵的flUID，(2)fi阳离子 传导性听力损失的原因(例如，flUID、脱节听小骨、fiX听小骨)，以及(3)监测 由颅内压变化引起的中耳僵硬的变化。拟议的工作不包括- 世界上唯一的在线WAI数据库和相应的网站，该数据库是在 这项资助的第一个fi周期，从标准成人耳朵的WAI测量到也包括具有 婴儿和儿童的特殊fic病理和耳朵。拟议的工作还包括(1)实验室- 基于声学测量和CT耳道扫描，以了解为什么FDA批准的两个WAI 测量系统在测量方面有系统差异，以及(2)使用数据库 进行跨研究的数据分析，比较正常耳朵和正常耳朵的WAI测量结果 特殊的fic病理，以确定最能区分正常耳朵和 患有特殊fic病理的耳朵。拟议工作的第二个重点是研究型教育。 史密斯学院的本科生。史密斯学院是一所女子文科学院。本科生工程- NEINING学生将积极参与拟议工作的所有领域，旨在鼓励 他们将继续在研究生阶段接受教育。

PROJECT SUMMARY / ABSTRACT This work aims to develop wideband acoustic immittance (WAI) measures as a noninvasive auditory diagnostic tool, where WAI refers to the collection of measurements that include absorbance, power reflectance, impedance, and related quantities. Potential use of these measures includes (1) detection of fluid in newborn and young infant ears where tympanometry is less successful, (2) identification of the cause of a conductive hearing loss (e.g., fluid, disarticulated ossicle, fixed ossicle), and (3) monitoring changes in middle-ear stiffness that result from intracranial pressure changes. The proposed work ex- tends the world's only online WAI database and corresponding website, which was developed during the first cycle of this grant, from WAI measurements on normative adult ears to also include ears with specific pathologies and ears of babies and children. The proposed work also includes (1) laboratory- based acoustical measurements and CT ear-canal scans to understand why the two FDA-approved WAI measurement systems have systematic differences in their measurements and (2) utilizing the database to perform data analyses across studies to compare WAI measures on both normal ears and ears with specific pathologies in order to identify WAI features that best differentiate between normal ears and ears with specific pathologies. A second emphasis of the proposed work is the research-based education of undergraduate students at Smith College, an all-women's liberal arts college. Undergraduate engi- neering students will be actively involved in all areas of the proposed work, with the goal of encouraging them to continuing their education at the graduate level.