High Intensity Interval Training for Knee Osteoarthritis

项目摘要/摘要 拟议项目的总体目标是改善膝骨性关节炎患者的治疗结果。 (OA)使用一种可纳入疾病康复方法的新运动方法 管理：高强度间歇训练(HIIT)。与其他体力活动干预不同的是膝骨性关节炎 目前可用的或正在调查中的HIIT只需要最少的时间(每节课10分钟的锻炼，2 每周)，有可能迅速改善身体机能、疼痛和其他健康状况 方面。这项拟议研究的理由是建立在HIIT在几个临床上有效的证据之上的 然而，在患有骨性关节炎的个人中，这种可行性是未知的，他们面临着独特和实质性的 锻炼的挑战，特别是功能限制和疼痛。这一系列研究的主要假设 膝骨性关节炎患者将坚持HIIT，报告方案耐受性良好，并将在临床上 在以成绩为基础的身体机能以及膝关节力量、身体成分、 和心肺功能，在完成HIIT后。一项单臂可行性和概念验证研究 对30例症状性膝骨性关节炎患者进行每周HIIT干预。本研究具有创新性。 因为它探索了一种新的康复方法，具有广泛推广的潜力， 改善膝骨性关节炎患者的身体功能和疼痛。在目标1中，多学科团队，包括 在办公自动化、体力活动方面的专长， 心脏病学， 和生物统计学，将审查一项 有症状的膝骨性关节炎患者的12周HIIT计划。我们将确定坚守和容忍 通过6周和12周的评估，评估患者的HIIT、可接受性以及招募和保留率。在……里面 目标2，我们将在6周和12周时确定基于绩效的体检结果的短期变化 功能、膝关节骨性关节炎症状性负荷(疼痛)、平衡、等长膝关节伸肌和屈肌力量(因素 与身体功能和有症状的膝关节骨关节炎进展有关)、心肺功能和身体状况 参加HIIT干预的症状性膝骨性关节炎患者的构成。如果HIIT 干预措施的耐受性良好，前景看好，初步研究结果将奠定基础 一项大型随机对照试验，以确定HIIT的疗效作为一种革命性的治疗方法 加强膝关节骨性关节炎的康复和管理。

Project Summary/Abstract The overall goal of the proposed project is to improve outcomes among individuals with knee osteoarthritis (OA) using a novel exercise method that can be included in rehabilitation approaches for disease management: high intensity interval training (HIIT). Unlike other physical activity interventions for knee OA currently available or under investigation, HIIT requires minimal time (10 minutes of exercise per session, 2 times per week) with the potential to quickly provide improvements in physical function, pain, and other health aspects. The rationale for the proposed research is built upon the proof that HIIT is effective in several clinical populations; however, the feasibility is unknown among individuals with OA, who face unique and substantial challenges to exercise, particularly functional limitations and pain. The main hypotheses of this line of research is that patients with knee OA will adhere to HIIT, report good tolerability of the program, and will have clinically important improvements in performance-based physical function, as well as knee strength, body composition, and cardiorespiratory fitness, after completing HIIT. A single-arm feasibility and proof-of-concept study of a 12- week HIIT intervention will be conducted in 30 patients with symptomatic knee OA. This study is innovative because it explores a novel rehabilitation approach, with potential for widespread generalizability, to improve physical function and pain in people with knee OA. In Aim 1, the multidisciplinary team, with expertise in OA, physical activity, cardiology, and biostatistics, will examine the feasibility and acceptability of a 12-week HIIT program in patients with symptomatic knee OA. We will determine adherence to and tolerability of HIIT, acceptability, and recruitment and retention rates of patients through 6- and 12-week assessments. In Aim 2, we will determine short-term changes at 6- and 12-weeks in outcomes of performance-based physical function, knee OA symptomatic burden (pain), balance, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), cardiorespiratory fitness, and body composition among patients with symptomatic knee OA participating in a HIIT intervention. If the HIIT intervention is shown to be well-tolerated and promising, results of this preliminary study will lay the foundation for a large randomized controlled trial to establish the efficacy of HIIT as a revolutionary approach for enhancing the rehabilitation and management of knee OA.