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High Intensity Interval Training for Knee Osteoarthritis

高强度间歇训练治疗膝骨关节炎

基本信息

批准号：
9317625
负责人：
Yvonne M Golightly
金额：
$ 23.33万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-12 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9317625
关键词：
Acute Adherence Adult Adverse event Aerobic Exercise Age-Years Arthralgia Biometry Body Composition Cardiology Chronic Obstructive Airway Disease Clinical Comorbidity Data Degenerative polyarthritis Disease Management Educational Intervention Equilibrium Equipment Evaluation Exercise Extensor Face Flexor Foundations Goals Guidelines Health Health Benefit Heart failure Individual Interval training Intervention Investigation Isometric Exercise Joints Knee Knee Osteoarthritis Malignant Neoplasms Methods Motivation Obesity Outcome Pain Participant Patients Performance Physical Function Physical activity Population Protocols documentation Public Health Randomized Controlled Trials Recovery Recruitment Activity Rehabilitation therapy Reporting Research Research Personnel Research Training Resistance Rest Risk Risk Factors Strenuous Exercise Stroke Supervision Symptoms Time Training Programs United States United States Dept. of Health and Human Services Walking Weight arm base cardiorespiratory fitness disability evidence base exercise intensity improved improved outcome innovation lifetime risk moderate-to-vigorous physical activity multidisciplinary muscle strength novel novel strategies primary outcome programs randomized trial rehabilitation management retention rate secondary outcome strength training treadmill

项目摘要

Project Summary/Abstract The overall goal of the proposed project is to improve outcomes among individuals with knee osteoarthritis (OA) using a novel exercise method that can be included in rehabilitation approaches for disease management: high intensity interval training (HIIT). Unlike other physical activity interventions for knee OA currently available or under investigation, HIIT requires minimal time (10 minutes of exercise per session, 2 times per week) with the potential to quickly provide improvements in physical function, pain, and other health aspects. The rationale for the proposed research is built upon the proof that HIIT is effective in several clinical populations; however, the feasibility is unknown among individuals with OA, who face unique and substantial challenges to exercise, particularly functional limitations and pain. The main hypotheses of this line of research is that patients with knee OA will adhere to HIIT, report good tolerability of the program, and will have clinically important improvements in performance-based physical function, as well as knee strength, body composition, and cardiorespiratory fitness, after completing HIIT. A single-arm feasibility and proof-of-concept study of a 12- week HIIT intervention will be conducted in 30 patients with symptomatic knee OA. This study is innovative because it explores a novel rehabilitation approach, with potential for widespread generalizability, to improve physical function and pain in people with knee OA. In Aim 1, the multidisciplinary team, with expertise in OA, physical activity, cardiology, and biostatistics, will examine the feasibility and acceptability of a 12-week HIIT program in patients with symptomatic knee OA. We will determine adherence to and tolerability of HIIT, acceptability, and recruitment and retention rates of patients through 6- and 12-week assessments. In Aim 2, we will determine short-term changes at 6- and 12-weeks in outcomes of performance-based physical function, knee OA symptomatic burden (pain), balance, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), cardiorespiratory fitness, and body composition among patients with symptomatic knee OA participating in a HIIT intervention. If the HIIT intervention is shown to be well-tolerated and promising, results of this preliminary study will lay the foundation for a large randomized controlled trial to establish the efficacy of HIIT as a revolutionary approach for enhancing the rehabilitation and management of knee OA.

项目总结/文摘