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Joint Hypermobility and Lower Body Osteoarthritis

关节过度活动和下半身骨关节炎

基本信息

批准号：
9041523
负责人：
Yvonne M Golightly
金额：
$ 35.46万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9041523
关键词：
Address Adult Affect Age Ankle Articular Range of Motion Biomechanics Biometry Body mass index Clinical County Coupled Cross-Sectional Studies Data Data Set Degenerative polyarthritis Diagnosis Disease Epidemiologist Epidemiology Exercise Female Foot joint structure Genetic Genetic study Goals Health Health Care Costs Hip region structure Injury Intervention Joint Laxity Joints Knee Knee Osteoarthritis Knowledge Lead Longitudinal Studies Measures Mechanics Medical Care Costs Modeling Musculoskeletal Non obese Obesity Odds Ratio Operative Surgical Procedures Participant Patients Prevalence Prevention Prevention approach Preventive Intervention Principal Investigator Public Health Radiology Specialty Reading Recording of previous events Reporting Research Research Personnel Rheumatology Risk Risk Factors Role Sample Size Sampling Shoes Site Staging Stress Time Tissues Translational Research United States United States National Institutes of Health Variant Vertebral column Woman Youth age group ankle joint clinical practice defined contribution disability effective therapy experience foot hazard high risk joint function joint injury joint mobilization male men multidisciplinary neuromuscular orthotics physical therapist radiologist sex

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed project is to define the contribution of joint hypermobility to lower body osteoarthritis (OA). Results of this study wil inform clinical practice and determine groups at high risk for OA who require targeted prevention or intervention approaches. The rationale for the proposed research is that: 1) joint hypermobility changes joint mechanics, 2) joint hypermobility is an expected independent risk factor for OA, and 3) joint hypermobility increases the risk of injury, a major risk factor for OA. The central hypothesis is that joint hypermobility is associated with lower body OA (lumbar spine, hips, knees, ankles, and feet) and that joint hypermobility magnifies the effects of other OA risk factors (i.e., joint injury). In Aim 1, we will assess the cross-sectional and longitudinal relationships of joint hypermobility with prevalent, incident, and progressive lumbar spine, hip, and knee OA. We will examine these relationships by age, sex, and body mass index because joint hypermobility declines with age, is more common in women than men, and varies with obesity. In Aim 2, we will evaluate whether joint hypermobility interacts with joint injury with regard to prevalent, incident, and progressive lumbar spine, hip, and knee OA. In Aim 3, we will explore the cross- sectional relationship of joint hypermobility and prevalent OA at the foot and ankle, joints that have not been examined in prior studies of joint hypermobility and OA. To achieve these aims, we will conduct the largest study to date of over 6900 participants from three large studies of participants with and without OA. OA, injury, and joint hypermobility data were consistently and identically measured across all 3 studies. The multidisciplinary team includes collaborative and productive researchers and clinicians with expertise in OA and injury epidemiology, rheumatology, musculoskeletal radiology, biomechanics, and biostatistics. The Principal Investigator is an Early Stage Investigator, an OA and injury epidemiologist, and an experienced physical therapist. She is in her final year as a NIH/NCATS (National Center for Advancing Translational Sciences) KL2 Scholar in which she is developing independent research on non-pharmacologic / non- surgical interventions for biomechanical risk factors of OA.

描述（由申请人提供）：拟议项目的总体目标是确定关节过度活动对下半身骨关节炎（OA）的影响。这项研究的结果将为临床实践提供参考，并确定需要有针对性的预防或干预方法的骨关节炎高危人群。本研究的基本原理是：1) 关节过度活动改变关节力学，2) 关节过度活动是 OA 的预期独立危险因素，3) 关节过度活动增加受伤风险，这是 OA 的主要危险因素。中心假设是关节过度活动与下半身 OA（腰椎、臀部、膝盖、脚踝和脚）相关，并且关节过度活动会放大其他 OA 危险因素（即关节损伤）的影响。在目标 1 中，我们将评估横截面和纵向关节过度活动与流行、偶发和进行性腰椎、髋部和膝部 OA 的关系。我们将通过年龄、性别和体重指数来检查这些关系，因为关节活动过度会随着年龄的增长而下降，在女性中比男性更常见，并且随着肥胖程度的不同而变化。在目标 2 中，我们将评估关节过度活动是否与常见、偶发和进行性腰椎、髋部和膝部 OA 的关节损伤相互作用。在目标 3 中，我们将探讨关节过度活动与足部和踝部常见 OA 的横截面关系，这些关节在先前的关节过度活动和 OA 研究中尚未进行检查。为了实现这些目标，我们将开展迄今为止最大规模的研究，涉及 6900 多名参与者，这些研究来自三项针对患有和不患有 OA 的参与者的大型研究。所有 3 项研究中测量的 OA、损伤和关节过度活动度数据都是一致且相同的。多学科团队包括协作且高效的研究人员和临床医生，他们在 OA 和损伤流行病学、风湿病学、肌肉骨骼放射学、生物力学和生物统计学方面拥有专业知识。首席研究员是一名早期研究员、一名 OA 和伤害流行病学家以及一名经验丰富的物理治疗师。这是她作为 NIH/NCATS（国家转化科学促进中心）KL2 学者的最后一年，她正在开展针对 OA 生物力学危险因素的非药物/非手术干预措施的独立研究。