Pathogenesis and therapeutic targeting of immune disorders

项目摘要/摘要 免疫反应失调在多种肿瘤的发病和表达中具有重要作用。 造成巨大发病率和死亡率负担的一系列疾病。培训的总体目标 格兰特将为3名博士前候选人提供培训，他们的研究将揭示致病机制 免疫介导性疾病和促进变革性治疗方法，与使命一致 美国国立卫生研究院的。候选人将从免疫学研究生计划(IMMGP)和医学 辛辛那提儿童医院医学中心(CCHMC)和加州大学的科学家培训计划 辛辛那提医学院(UCCOM)。位于CCHMC内，是首屈一指的儿科研究之一 在美国，IMMGP吸引了一批强大而多样化的申请者。IMMGP学生收到 免疫学、研究伦理、拨款撰写和生物统计学方面的示范教学。培训 该计划将由一名主任和联席主任(希尔德曼和辛格博士)领导，他与34名杰出的 培训学院(TF)，在指导博士生方面有丰富的经验。学生们将与一个 来自CCHMC/UCCOM多个部门的各种工作组(包括医学博士、医学博士和博士)， 他们共同关注对人类疾病的免疫学基础的机械性理解。 参加这个培训计划的学生将沉浸在一个独特的环境中：TF有充足的资金进行研究 从基础免疫学到疾病动物模型再到人类患者临床试验的项目 提供巨大的机构资源(例如，支持研究生教育和教师研究，削减- EDGE核心设施、独特的患者队列)；与 德国大学和研究所为国际研究提供了独特的机会 免疫学。该项目的毕业生将独一无二地准备带来免疫学方面的创新 将实验室工作台搬到床边，并为独立研究生涯做好充分准备。

Project Summary/Abstract Dysregulated immune responses are of central importance to the pathogenesis and expression of a wide spectrum of diseases that cause an immense burden of morbidity and mortality. The overall Aim of the training grant is to provide training for 3 pre-doctoral candidates, whose research will uncover pathogenic mechanisms of immune-mediated disease and facilitate transformative therapeutic approaches, consistent with the mission of the NIH. Candidates will be recruited from the Immunology Graduate Program (ImmGP) and the Medical Scientist Training Program at Cincinnati Children’s Hospital Medical Center (CCHMC) and the University of Cincinnati College of Medicine (UCCOM). Housed within CCHMC, one of the premiere pediatric research institutions in the US, the ImmGP attracts a strong and diverse pool of applicants. ImmGP students receive exemplary didactic instruction in immunology, research ethics, grant writing, and biostatistics. The training program will be led by a Director and Co-Director (Drs. Hildeman and Singh) who, along with 34 outstanding Training Faculty (TF), have significant experience in mentoring pre-doctoral students. Students will work with a diverse group of TF (comprised of MDs, MD/PhDs, and PhDs), from multiple departments at CCHMC/UCCOM, who share a collective focus on the mechanistic understanding of the immunologic basis of human disease. Students in this training program will be immersed in a distinctive environment: TF have well-funded research programs that span basic immunology to animal models of disease to clinical trials in human patients; CCHMC provides tremendous institutional resources (e.g., support for graduate education and faculty research, cutting- edge core facilities, unique patient cohorts); a collaborative research student exchange program with a German University and Research Institute provides a unique opportunity for international studies in immunology. Graduates of this program will be uniquely poised to bring innovations in immunology from the laboratory bench to the bedside and will be well-prepared for independent research careers.