The effect of developmental HL on cellular properties in the auditory striatum

 描述(申请人提供)：发育性听力损失与知觉障碍和语言习得延迟有关。虽然知觉缺陷是最重要的，但一项新的文献表明，发育性HL也对认知过程有影响。如果是这样的话，那么连接到听觉皮质的大脑结构可能会因为一段时间的剥夺而改变。一个与发声学习有关的大脑区域，与听觉相关 行为缺陷和语言障碍是纹状体。此外，听觉皮质和接受听觉输入的纹状体区域之间的投射可以驱动行为反应。鉴于纹状体在学习过程中扮演的基本角色，发育性听力损失可能在行为缺陷中起到致病作用。这一建议的核心假设是，纹状体中的细胞属性在导致行为缺陷的发育性听力损失后持续改变。目的1将调查发育性听力损失是否导致纹状体细胞缺陷。目标2将确定纹状体细胞特性的变化是否与行为缺陷相关。总之，这项提议将揭示听觉接受者的细胞特性 纹状体在发育过程中容易受到一过性HL的影响，并提供了一种基于听觉的学习缺陷的动物模型，如中耳炎儿童。

 DESCRIPTION (provided by applicant): Developmental hearing loss is associated with perceptual deficits and delayed language acquisition. Although perceptual sensory deficits are of primary importance, an emerging literature suggests that developmental HL also has an impact on cognitive processes. If so, then brain structures connected to auditory cortex may be altered by a period of deprivation. One brain region implicated in vocal learning, auditory related behavioral deficits, and language impairments is the striatum. Moreover, the projections between the auditory cortex and regions of the striatum receiving auditory inputs can drive behavioral responses. Given the fundamental role that the striatum plays during learning, developmental hearing loss may play a causative role in behavioral deficits. The core hypothesis of this proposal is that cellular properties in the striatum are persistently altered following developmental hearing loss that lead to behavioral deficits. Aim 1 will investigate whether developmental hearing loss induces cellular deficits in the striatum. Aim 2 will determine whether changes to cellular properties in the striatum are correlated with behavioral deficits. Together, this proposal will reveal whether cellular properties in the auditory-recipient striatum are vulnerable to transient HL during development, and offer an animal model on auditory-based learning deficits as seen in children with Otitis Media.