The effect of developmental HL on cellular properties in the auditory striatum

发育性 HL 对听觉纹状体细胞特性的影响

• 批准号: 9322552
• 负责人: Todd M. Mowery
• 金额: $ 15.85万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9322552
• 关键词: Acoustics; Adult; Age; Animal Model; Animals; Auditory; Auditory area; Behavioral; Brain; Brain region; Cells; Child; Childhood; Control Animal; Corpus striatum structure; Development; Ear; Earplug; External auditory canal; Functional disorder; Gays; Impaired cognition; Impairment; Language Delays; Language Development; Lead; Learning; Literature; Measures; Membrane; Neurocognitive; Neurons; Noise; Otitis Media; Perception; Physiology; Play; Preparation; Property; Role; Sensory; Slice; Stimulus; Structure; Synapses; Synaptic plasticity; System; Training; Whole-Cell Recordings; base; behavior measurement; behavioral response; classical conditioning; cognitive process; critical period; deprivation; experience; experimental study; hearing impairment; language impairment; postnatal; postsynaptic; public health relevance; response; vocal learning

 DESCRIPTION (provided by applicant): Developmental hearing loss is associated with perceptual deficits and delayed language acquisition. Although perceptual sensory deficits are of primary importance, an emerging literature suggests that developmental HL also has an impact on cognitive processes. If so, then brain structures connected to auditory cortex may be altered by a period of deprivation. One brain region implicated in vocal learning, auditory related behavioral deficits, and language impairments is the striatum. Moreover, the projections between the auditory cortex and regions of the striatum receiving auditory inputs can drive behavioral responses. Given the fundamental role that the striatum plays during learning, developmental hearing loss may play a causative role in behavioral deficits. The core hypothesis of this proposal is that cellular properties in the striatum are persistently altered following developmental hearing loss that lead to behavioral deficits. Aim 1 will investigate whether developmental hearing loss induces cellular deficits in the striatum. Aim 2 will determine whether changes to cellular properties in the striatum are correlated with behavioral deficits. Together, this proposal will reveal whether cellular properties in the auditory-recipient striatum are vulnerable to transient HL during development, and offer an animal model on auditory-based learning deficits as seen in children with Otitis Media.

 描述（由申请人提供）：发育性听力损失与感知缺陷和语言习得延迟有关。虽然知觉的感觉缺陷是最重要的，一个新兴的文献表明，发展HL也有认知过程的影响。如果是这样的话，那么与听觉皮层相连的大脑结构可能会因一段时间的剥夺而改变。一个与声音学习有关的大脑区域，听觉相关 行为缺陷和语言障碍是纹状体。此外，听觉皮层和接收听觉输入的纹状体区域之间的投射可以驱动行为反应。鉴于纹状体在学习过程中发挥的基本作用，发育性听力损失可能在行为缺陷中发挥致病作用。该建议的核心假设是，纹状体中的细胞特性在发育性听力损失后持续改变，导致行为缺陷。目的1：研究发育性听力损失是否会导致纹状体细胞的损伤。目的2将确定纹状体细胞特性的变化是否与行为缺陷相关。总之，这项建议将揭示是否在细胞特性的受体 纹状体在发育过程中易受短暂性HL影响，并提供了一种在患有中耳炎的儿童中观察到的基于神经系统的学习缺陷的动物模型。