Maternal obesity, child executive functions and child weight gain

母亲肥胖、儿童执行功能和儿童体重增加

• 批准号: 9278240
• 负责人: Bernard F Fuemmeler
• 金额: $ 61.41万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278240
• 关键词: 4 year old; 6 year old; Address; Affect; Affective; Appetite Regulation; Attention; Behavior; Biological; Biological Assay; Birth; Blood; Blood specimen; Body Weight decreased; Body mass index; Brain; Child; Childbirth; Childhood; Cognitive; County; Data; Decision Making; Desire for food; Development; Dietary intake; Distal; Eating; Eating Behavior; Exercise; First Pregnancy Trimester; Future; Goals; Growth; Health; Individual Differences; Knowledge; Laboratories; Lead; Life Style; Link; Mediating; Medical Records; Memory; Metabolic; Metabolism; Modeling; Monocyte Chemoattractant Protein-1; Mothers; Neurocognitive; Obesity; Outcome; Performance; Perinatal; Pregnancy; Pregnancy Complications; Prevention; Prevention program; Prevention strategy; Preventive Intervention; Process; Prospective Studies; Public Health; Recruitment Activity; Research; Risk; Risk Factors; Self-control as a personality trait; Shapes; Short-Term Memory; Stress; Surveys; Umbilical Cord Blood; Visit; Weight; Weight Gain; Woman; base; cohort; cost effective; cytokine; delivery complications; early childhood; eating in absence of hunger; effective therapy; executive function; gestational weight gain; hedonic; improved; inattention; individualized prevention; infancy; maternal obesity; neurodevelopment; neuroinflammation; nutrition; obesity in children; obesity risk; offspring; postnatal; prenatal; prepregnancy obesity; prospective; public health relevance; success

 DESCRIPTION (provided by applicant): This project seeks to evaluate a model of childhood obesity that begins with maternal pre-pregnancy obesity as a distal risk factor contributing to the development of appetite dysregulation and poor executive functioning, increasing a child's risk for excess weight gain. The study will take advantage of a perinatal birth cohort with over 2000 births that has obtained prospectively collected data from the first trimester through infancy, inclusive of pre-pregnancy weight at the first prenatal visit, gestational weight gain, surveys regarding nutrition, stress and lifestyle behaviors, data from medical records on pregnancy and birth complications, maternal blood at the first trimester, and umbilical cord blood at delivery. The proposed study will recruit mother/child dyads from this cohort and conduct detailed assessments of IQ, executive functions (attention, inhibitory control, memory, affective-based decision making), appetite regulation using the eating in the absence of hunger laboratory paradigm, dietary intake, and anthropometric growth among 400 children at ages 4 years and two- years later at 6 years. Maternal blood specimens collected during the first trimester and cord blood at birth will be used to assay Interleuken-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), two cytokines important in both metabolism and normal brain development. The primary hypothesis is that maternal obesity influences neurodevelopmental processes that regulate appetite and executive functions resulting in increased risk for obesity in offspring. A secondary/exploratory hypothesis is that markers of prenatal neuro-inflammatory processes mediate the effect of maternal obesity on adverse child outcomes. Conducting this study in the context of an established perinatal birth cohort provides a cost-effective opportunity to achieve our aims. The study will aid in disentangling the associations between maternal pre-pregnancy obesity, childhood appetite regulation, executive functions and child weight gain. By understanding how developmental factors shape individual differences that predict child obesity, it is possible to markedly improve prevention interventions by targeting key risk factors for childhood obesity at earlier developmental periods and create tailored prevention programs that shift children's weight trajectory toward more healthy outcomes.