Elucidating links between ADHD symptoms and tobacco/alcohol use trajectories

阐明多动症症状与烟草/酒精使用轨迹之间的联系

• 批准号: 8265062
• 负责人: Bernard F Fuemmeler
• 金额: $ 10.6万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8265062
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Age-Years; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Area; Attention deficit hyperactivity disorder; Behavioral; Child Development; Chronic; Clinical; Conduct Disorder; Data; Data Analyses; Databases; Development; Diagnosis; Drug usage; Epidemiology; Ethnic Origin; Etiology; Factor Analysis; Gender; Gender Role; General Population; Growth; Health; Heavy Drinking; Hyperactive behavior; Impulsivity; Income; Individual; Joints; Knowledge; Link; Longitudinal Surveys; Malignant Neoplasms; Methods; Minority; Modeling; Outcome; Pathway interactions; Phenotype; Play; Population; Prevention approach; Preventive Intervention; Probability; Property; Race; Recording of previous events; Research; Risk; Role; Smoke; Smoking; Subgroup; Surveys; Symptoms; Techniques; Time; Tobacco; Tobacco use; Variant; abstracting; addiction; cigarette smoking; clinical Diagnosis; cohort; early adolescence; inattention; innovation; young adult

Abstract Numerous adverse health consequences arise from tobacco and alcohol use, though the pathways of tobacco and alcohol use from early adolescence into adulthood and the factors that best predict these pathways are not well understood. Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke and use alcohol at higher proportions than those without ADHD. Moreover, ADHD symptoms (i.e., hyperactivity- impulsivity [HI], inattention [IN]) below the threshold necessary for clinical diagnosis increase the risk of cigarette smoking. A clearer understanding of the developmental relationship between these symptom domains and substance use has the potential to elucidate the potential etiology of smoking and problem drinking as well as inform treatment and prevention approaches in both clinical groups and in the general population. Using traditional and innovative/advanced analytic methods for identifying population subgroups and dynamic properties of substance use (factor mixture modeling, latent curve modeling, and growth mixture modeling), we will analyze extant longitudinal data that contains information on history of HI and IN symptoms and tobacco and alcohol use outcomes. Two nationally representative databases will be used (The National Longitudinal Survey of Adolescent Health-Add Health and Panel Survey of Income Dynamics - Child Development Supplement/Transition to Adulthood - PSID-CDS/TA). The investigative team has expertise in the areas of ADHD, addiction, behavioral epidemiology and longitudinal data analysis and thus, is well poised to undertake the proposed research. The successful completion of this proposal will result in refined knowledge concerning the influence of HI and IN symptoms on substance use from adolescence to young adulthood. Such knowledge is necessary for effective preventive intervention planning and implementation.

摘要