Elucidating links between ADHD symptoms and tobacco/alcohol use trajectories

摘要 烟草和酒精的使用产生了许多有害的健康后果，尽管烟草的途径 从青春期早期到成年期饮酒，而最能预测这些途径的因素并不是 很好理解。被诊断为注意缺陷多动障碍(ADHD)的个人吸烟和使用 酒精的比例比那些没有ADHD的人要高。此外，ADHD症状(即多动- 冲动[HI]、注意力不集中[IN])低于临床诊断所必需的阈值会增加罹患 抽烟。对这些症状之间的发展关系有更清晰的认识 领域和物质使用有可能阐明吸烟和问题的潜在病因。 以及在临床组和一般人群中提供治疗和预防方法的信息 人口。使用传统和创新/先进的分析方法识别人口亚群 和物质使用的动态特性(要素混合模型、潜伏曲线模型和生长混合模型 建模)，我们将分析现有的包含HI和IN症状历史信息的纵向数据 以及烟草和酒精的使用结果。将使用两个具有全国代表性的数据库(国家数据库 青少年健康纵向调查--增加健康和收入动态小组调查--儿童 发展补充资料/向成年期过渡--PSID-CDS/TA)。调查小组在以下方面具有专业知识 ADHD、成瘾、行为流行病学和纵向数据分析等领域因此处于有利地位 承担这项拟议的研究。这项建议的成功完成将带来精炼的知识 关于从青春期到青春期HI和IN症状对物质使用的影响。 这些知识对于有效的预防性干预规划和实施是必要的。

Abstract Numerous adverse health consequences arise from tobacco and alcohol use, though the pathways of tobacco and alcohol use from early adolescence into adulthood and the factors that best predict these pathways are not well understood. Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke and use alcohol at higher proportions than those without ADHD. Moreover, ADHD symptoms (i.e., hyperactivity- impulsivity [HI], inattention [IN]) below the threshold necessary for clinical diagnosis increase the risk of cigarette smoking. A clearer understanding of the developmental relationship between these symptom domains and substance use has the potential to elucidate the potential etiology of smoking and problem drinking as well as inform treatment and prevention approaches in both clinical groups and in the general population. Using traditional and innovative/advanced analytic methods for identifying population subgroups and dynamic properties of substance use (factor mixture modeling, latent curve modeling, and growth mixture modeling), we will analyze extant longitudinal data that contains information on history of HI and IN symptoms and tobacco and alcohol use outcomes. Two nationally representative databases will be used (The National Longitudinal Survey of Adolescent Health-Add Health and Panel Survey of Income Dynamics - Child Development Supplement/Transition to Adulthood - PSID-CDS/TA). The investigative team has expertise in the areas of ADHD, addiction, behavioral epidemiology and longitudinal data analysis and thus, is well poised to undertake the proposed research. The successful completion of this proposal will result in refined knowledge concerning the influence of HI and IN symptoms on substance use from adolescence to young adulthood. Such knowledge is necessary for effective preventive intervention planning and implementation.