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Variation of vitamin D metabolism and regulatory genes in the Yup’ik population

尤帕克族人群维生素 D 代谢和调控基因的变异

基本信息

批准号：
9307553
负责人：
Katrina G Claw
金额：
$ 5.71万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9307553
关键词：
Address Adherence Affect African American Alaska Alaska Native Biological Markers Biomedical Research Candidate Disease Gene Cause of Death Collaborations Communities Community Health Copy Number Polymorphism DNA Data Diet Disease Eating Elderly Ethics Ethnic group Fishes Food Frequencies Future Genes Genetic Genetic Predisposition to Disease Genetic Variation Genomic medicine Genomics Geography Health Health Priorities Heart Diseases Hepatic Heritability Homeostasis Human Individual Infection Intake Intervention Knowledge Life Style Link Literature Liver Mammals Marines Measurement Measures Mediating Metabolism Minority Groups Mixed Function Oxygenases Native-Born Osteoporosis Participant Perception Pharmacogenomics Population Positioning Attribute Proteins Public Health RNA Regulator Genes Research Research Personnel Rickets Risk Rivers Role Sampling Seasonal Variations Serum Single Nucleotide Polymorphism Skin Source Sunlight Technology Testing Transcript Trust Universities Variant Vitamin D Vitamin D Deficiency Washington Work Yukon Kuskokwim Yup&apos ik arctic circle base burden of illness cancer risk candidate identification community living community planning data sharing expectation genome-wide genomic variation informant insight new technology next generation precision medicine public health relevance remote communities research study response transcriptome sequencing trend volunteer western diet whole genome young adult

项目摘要

DESCRIPTION (provided by applicant): Vitamin D levels vary seasonally with sunlight availability and with differences in diet. Seasonal variation of vitamin D levels is especially apparent at high latitudes where adequate sunlight may not be available, such as in Yup'ik Alaska Native communities living within the Arctic Circle (66°33'N). Previous research has shown that a traditional diet high in marine-mammals and fish may contribute to the high levels of vitamin D in Yup'ik people, but recent trends show that the traditional diet intake is declining due to shifts to more Westernized foods, and this may result in vitamin D deficiency in Yup'ik young adults. Vitamin D deficiency is a widespread public health problem that is linked to increased risk for cancer, heart disease, and many other conditions. Despite evidence that variability in vitamin D (25(OH)D3) concentration is heritable, the current genetic literature only explains a small percentage of the heritability. This proposal seeks to identify and characterize genetic variation in vitamin D metabolism and regulatory genes and to look for associations with serum vitamin D (25(OH)D3) levels and traditional diet in a cross-section of Yup'ik Alaska Native volunteers. To this end, I propose to apply novel technologies to identify genomic sources of serum 25(OH)D3 variability and to explore Yup'ik people's perceptions, understandings, and expectations for research involving genomic medicine. These findings will advance our understanding of vitamin D insufficiency; identify the facilitators and barriers to genomic research involving Yup'ik people; and position academic research collaborators to address current and future health priorities and concerns with precision medicine technologies in Alaska Native people.

描述（由申请人提供）：维生素D水平随阳光供应和饮食差异而季节性变化。维生素D水平的季节性变化在高纬度地区尤其明显，因为那里可能没有充足的阳光，例如生活在北极圈内的Yup'ik Alaska土著社区（北纬66° 33'）。以前的研究表明，海洋哺乳动物和鱼类含量高的传统饮食可能有助于Yup'ik人的维生素D水平高，但最近的趋势表明，传统饮食摄入量正在下降由于转向更西化的食物，这可能导致Yupik年轻人缺乏维生素D。维生素D缺乏是一个普遍的公共卫生问题，与癌症，心脏病和许多其他疾病的风险增加有关。尽管有证据表明维生素D（25（OH）D3）浓度的变异性是可遗传的，但目前的遗传文献仅解释了一小部分遗传性。该提案旨在确定和表征维生素D代谢和调控基因的遗传变异，并在Yup'ik阿拉斯加土著志愿者的横截面中寻找与血清维生素D（25（OH）D3）水平和传统饮食的关联。为此，我建议应用新技术来确定血清25（OH）D3变异的基因组来源，并探讨Yup'ik人的看法，理解和期望的研究涉及基因组医学。这些发现将促进我们对维生素D不足的理解;确定涉及Yup'ik人的基因组研究的促进因素和障碍;并定位学术研究合作者，以解决阿拉斯加原住民当前和未来的健康优先事项和精准医学技术问题。