Variation of vitamin D metabolism and regulatory genes in the Yup’ik population

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 DESCRIPTION (provided by applicant): Vitamin D levels vary seasonally with sunlight availability and with differences in diet. Seasonal variation of vitamin D levels is especially apparent at high latitudes where adequate sunlight may not be available, such as in Yup'ik Alaska Native communities living within the Arctic Circle (66°33'N). Previous research has shown that a traditional diet high in marine-mammals and fish may contribute to the high levels of vitamin D in Yup'ik people, but recent trends show that the traditional diet intake is declining due to shifts to more Westernized foods, and this may result in vitamin D deficiency in Yup'ik young adults. Vitamin D deficiency is a widespread public health problem that is linked to increased risk for cancer, heart disease, and many other conditions. Despite evidence that variability in vitamin D (25(OH)D3) concentration is heritable, the current genetic literature only explains a small percentage of the heritability. This proposal seeks to identify and characterize genetic variation in vitamin D metabolism and regulatory genes and to look for associations with serum vitamin D (25(OH)D3) levels and traditional diet in a cross-section of Yup'ik Alaska Native volunteers. To this end, I propose to apply novel technologies to identify genomic sources of serum 25(OH)D3 variability and to explore Yup'ik people's perceptions, understandings, and expectations for research involving genomic medicine. These findings will advance our understanding of vitamin D insufficiency; identify the facilitators and barriers to genomic research involving Yup'ik people; and position academic research collaborators to address current and future health priorities and concerns with precision medicine technologies in Alaska Native people.