Neonatal Morbidities and Psychological Processes Underlying the Association Between Preterm Birth and ADHD

早产与多动症之间关联的新生儿发病率和心理过程

• 批准号: 9816568
• 负责人: Allison Marie Momany
• 金额: $ 3.55万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-06 至 2020-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816568
• 关键词: 10 year old; 37 weeks gestation; Address; Adult; Affect; Age; Age-Months; Alcohol or Other Drugs use; Apgar Score; Archives; Area; Attention deficit hyperactivity disorder; Awareness; Behavior Disorders; Behavioral; Behavioral Symptoms; Biological; Birth; Birth Weight; Bronchopulmonary Dysplasia; Caring; Child; Child Development; Childhood; Clinic; Clinical; Clinical assessments; Clinics and Hospitals; Complex; Data; Databases; Development; Developmental Delay Disorders; Diagnosis; Disease; Emotional; Epidemiology; Etiology; Fellowship; Follow-Up Studies; Fostering; Foundations; Funding; Future; Genetic; Gestational Diabetes; Goals; Hospitalization; Hypertension; Individual; Infant; Infant Development; Informal Social Control; Iowa; Knowledge; Life; Link; Longevity; Maternal Complication of Pregnancy; Mediating; Mediator of activation protein; Medical; Mental disorders; Methods; Morbidity - disease rate; Neonatal; Neonatology; Neurocognition; Neurocognitive; Neurodevelopmental Disorder; Neuropsychology; Outcome; Parents; Patent Ductus Arteriosus; Patient Self-Report; Perinatal; Predisposition; Pregnancy; Premature Birth; Premature Infant; Preventive Intervention; Problem Solving; Process; Research; Research Training; Risk; Risk Factors; Role; Scientist; Severity of illness; Social Interaction; Specificity; Statistical Data Interpretation; Symptoms; Testing; Time; Training; Twin Multiple Birth; United States; Universities; Weight Gain; Work; Writing; aged; career; cohort; early childhood; economic cost; executive function; experience; follow-up; high risk infant; improved; infant morbidity; informant; information processing; insight; intraventricular hemorrhage; middle childhood; neonatal care; neonatal morbidity; neonatal period; neurodevelopment; peer; premature; prenatal; programs; psychologic; recruit; screening; sex; skills; social; statistics; sustained attention

Project Abstract Preterm birth affects approximately one out of every ten infants born in the United States, resulting in significant neonatal and life-long morbidities and economic costs. Preterm infants are at risk for developing a number of psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). Although a substantial body of work supports the association between preterm birth and ADHD, there is a critical need for a better understanding of the specific risk factors and mechanisms that link preterm birth to ADHD and its related developmental, neurocognitive, and socioemotional deficits. Preterm infants commonly endure neonatal morbidities (i.e., intraventricular hemorrhage [IVH], bronchopulmonary dysplasia [BPD], and patent ductus arteriosus [PDA]) that may be important predictors of risk for ADHD, yet work has not examined variability in neonatal morbidities and potential connections to ADHD and related deficits. Such research is essential to explicating the specific risk factors and mechanisms underlying the association between preterm birth and ADHD. The proposed research will determine whether specific neonatal morbidities (i.e., IVH, BPD, and PDA) are associated with ADHD-relevant developmental delays in early childhood (30 months of age) by utilizing an archival database from the University of Iowa High Risk Infant Follow-up Clinic. Further, the archival database will be used to identify preterm children (ages 6-10 years) for recruitment to a follow-up study examining neurocognition, socio-emotional processes, and ADHD symptomology. Neurocognition and socio- emotional processes at 6-10 years of age will be examined as mediators of the association between preterm birth and ADHD symptoms. The long-term objective of this research is to provide a better understanding of the mechanisms underlying links between preterm birth and ADHD, with the goal of improving prevention and intervention efforts. Notably, the complementary goals of this research and training plan, including gaining knowledge about neonatal morbidities and typical development and enhancing skills related to scientific writing, statistical analyses, and clinical assessment, will provide the applicant with a strong foundation for becoming an independent clinical scientist.

项目摘要 早产会影响美国出生的十个婴儿中的大约一个，导致 重大的新生儿和终身病态和经济成本。早产婴儿有发展的风险 精神疾病的数量，包括注意力缺陷多动障碍（ADHD）。虽然 大量的工作支持早产与多动症之间的关联，对 更好地理解将早产与多动症联系起来的特定风险因素和机制 相关的发展，神经认知和社会情感缺陷。早产婴儿通常会忍受 新生儿病毒（即脑室出血[IVH]，支气管肺发育不良[BPD]和专利 可能是多动症风险的重要预测指标，但工作尚未检查 新生儿的病态和与多动症和相关缺陷的潜在连接的变异性。这样的研究是 阐明早产之间关联的基础的特定风险因素和机制至关重要 出生和多动症。拟议的研究将确定特定的新生儿病毒是否（即IVH，BPD， 和PDA）与儿童早期（30个月大）在儿童时期与ADHD相关的发育延迟有关 利用爱荷华大学高风险婴儿随访诊所的档案数据库。此外，档案 数据库将用于识别早产儿（6-10岁）进行招募进行后续研究 检查神经认知，社会情感过程和ADHD症状。神经认知和社会 6-10岁的情感过程将被检查为早产之间关联的调解人 出生和多动症症状。这项研究的长期目标是更好地理解 早产和多动症之间存在联系的机制，目的是改善预防和 干预工作。值得注意的是，该研究和培训计划的互补目标，包括获得 有关新生儿的病毒和典型发展和增强与科学写作相关的技能的知识， 统计分析和临床评估将为申请人提供强大的基础 独立的临床科学家。