Neonatal Morbidities and Psychological Processes Underlying the Association Between Preterm Birth and ADHD

早产与多动症之间关联的新生儿发病率和心理过程

• 批准号: 9816568
• 负责人: Allison Marie Momany
• 金额: $ 3.55万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-06 至 2020-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816568
• 关键词: 10 year old; 37 weeks gestation; Address; Adult; Affect; Age; Age-Months; Alcohol or Other Drugs use; Apgar Score; Archives; Area; Attention deficit hyperactivity disorder; Awareness; Behavior Disorders; Behavioral; Behavioral Symptoms; Biological; Birth; Birth Weight; Bronchopulmonary Dysplasia; Caring; Child; Child Development; Childhood; Clinic; Clinical; Clinical assessments; Clinics and Hospitals; Complex; Data; Databases; Development; Developmental Delay Disorders; Diagnosis; Disease; Emotional; Epidemiology; Etiology; Fellowship; Follow-Up Studies; Fostering; Foundations; Funding; Future; Genetic; Gestational Diabetes; Goals; Hospitalization; Hypertension; Individual; Infant; Infant Development; Informal Social Control; Iowa; Knowledge; Life; Link; Longevity; Maternal Complication of Pregnancy; Mediating; Mediator of activation protein; Medical; Mental disorders; Methods; Morbidity - disease rate; Neonatal; Neonatology; Neurocognition; Neurocognitive; Neurodevelopmental Disorder; Neuropsychology; Outcome; Parents; Patent Ductus Arteriosus; Patient Self-Report; Perinatal; Predisposition; Pregnancy; Premature Birth; Premature Infant; Preventive Intervention; Problem Solving; Process; Research; Research Training; Risk; Risk Factors; Role; Scientist; Severity of illness; Social Interaction; Specificity; Statistical Data Interpretation; Symptoms; Testing; Time; Training; Twin Multiple Birth; United States; Universities; Weight Gain; Work; Writing; aged; career; cohort; early childhood; economic cost; executive function; experience; follow-up; high risk infant; improved; infant morbidity; informant; information processing; insight; intraventricular hemorrhage; middle childhood; neonatal care; neonatal morbidity; neonatal period; neurodevelopment; peer; premature; prenatal; programs; psychologic; recruit; screening; sex; skills; social; statistics; sustained attention

Project Abstract Preterm birth affects approximately one out of every ten infants born in the United States, resulting in significant neonatal and life-long morbidities and economic costs. Preterm infants are at risk for developing a number of psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). Although a substantial body of work supports the association between preterm birth and ADHD, there is a critical need for a better understanding of the specific risk factors and mechanisms that link preterm birth to ADHD and its related developmental, neurocognitive, and socioemotional deficits. Preterm infants commonly endure neonatal morbidities (i.e., intraventricular hemorrhage [IVH], bronchopulmonary dysplasia [BPD], and patent ductus arteriosus [PDA]) that may be important predictors of risk for ADHD, yet work has not examined variability in neonatal morbidities and potential connections to ADHD and related deficits. Such research is essential to explicating the specific risk factors and mechanisms underlying the association between preterm birth and ADHD. The proposed research will determine whether specific neonatal morbidities (i.e., IVH, BPD, and PDA) are associated with ADHD-relevant developmental delays in early childhood (30 months of age) by utilizing an archival database from the University of Iowa High Risk Infant Follow-up Clinic. Further, the archival database will be used to identify preterm children (ages 6-10 years) for recruitment to a follow-up study examining neurocognition, socio-emotional processes, and ADHD symptomology. Neurocognition and socio- emotional processes at 6-10 years of age will be examined as mediators of the association between preterm birth and ADHD symptoms. The long-term objective of this research is to provide a better understanding of the mechanisms underlying links between preterm birth and ADHD, with the goal of improving prevention and intervention efforts. Notably, the complementary goals of this research and training plan, including gaining knowledge about neonatal morbidities and typical development and enhancing skills related to scientific writing, statistical analyses, and clinical assessment, will provide the applicant with a strong foundation for becoming an independent clinical scientist.

项目摘要 在美国，每十个出生的婴儿中就有一个会受到早产的影响，导致 严重的新生儿发病率和终生发病率和经济成本。早产儿有患上 精神障碍的数量，包括注意力缺陷多动障碍(ADHD)。尽管一个 大量工作支持早产和ADHD之间的联系，迫切需要 更好地了解早产与ADHD及其相关的具体危险因素和机制 相关的发育、神经认知和社会情绪缺陷。早产儿通常会忍受 新生儿发病率(即脑室出血[IVH]、支气管肺发育不良[BPD]和未闭 动脉导管[PDA])可能是ADHD风险的重要预测因子，但研究尚未检验 新生儿发病率的变异性以及与ADHD和相关缺陷的潜在联系。这样的研究是 对解释早产与早产之间关联的具体风险因素和机制至关重要 出生和多动症。拟议的研究将确定特定的新生儿发病率(即IVH，BPD， 和PDA)在幼儿早期(30个月大)与ADHD相关的发育迟缓有关 利用爱荷华大学高危婴儿随访诊所的档案数据库。此外，档案馆 数据库将被用来确定招募早产儿(6-10岁)进行后续研究 检查神经认知、社会情绪过程和ADHD症状。神经认知和社会- 6-10岁儿童的情绪过程将作为早产和早产之间联系的中介。 出生和多动症症状。这项研究的长期目标是为了更好地了解 早产和ADHD之间潜在的联系机制，目的是改善预防和 干预努力。值得注意的是，这项研究和培训计划的补充目标，包括获得 关于新生儿发病率的知识以及与科学写作相关的典型发展和提高技能， 统计分析和临床评估将为申请者提供成为 一位独立的临床科学家。