Stroke Investigative Research & Educational Network (SIREN)

中风调查研究

• 批准号: 9441884
• 负责人: BRUCE OVBIAGELE
• 金额: $ 10万
• 依托单位: COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9441884
• 关键词: Address; Africa; Africa South of the Sahara; African; African American; Age; Attitude; Belief; Bioinformatics; Biological Process; Biometry; Biostatistics Core; CD80 gene; Candidate Disease Gene; Caregivers; Cause of Death; Characteristics; Chronic Kidney Failure; Clinical; Collaborations; Collection; Complex; Coronary Arteriosclerosis; Country; Data; Dementia; Diagnostic radiologic examination; Education; Environmental Risk Factor; Ethnic Origin; Formulation; Funding; Future; Gender; General Population; Genetic; Genetic Markers; Genetic Risk; Genetic screening method; Genomics; Ghana; Investigation; Knowledge; Medical Genetics; Mental Depression; Nature; Nigeria; Not Hispanic or Latino; Outcome; Pathway interactions; Patients; Pattern; Performance; Phenotype; Population Study; Prevention strategy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Risk Factors; Severities; Site; South Africa; Stroke; Techniques; Testing; United States; United States National Institutes of Health; Vascular Diseases; base; biobank; cohort; disability; epidemiology study; experience; genetic risk factor; improved; multidisciplinary; novel; phenomics; prospective; stroke survivor; stroke symptom

Although stroke is a discrete phenotype, it is the clinical culmination of several complex and interacting biological processes, precipitated by various genetic and environmental factors, thereby making ready analyses of its underlying mechanisms a challenge. However, the formulation of successful tailor-made prevention strategies for limiting the immense personal and societal burden of stroke in Sub-Saharan Africa (SSA) is contingent on a better understanding of the predisposing risk factors for stroke in the region, which may not necessarily match the nature of stroke risk factors described among other people on other continents. Indeed, the underlying risk factors for stroke in SSA have hitherto not been comprehensively characterized, and currently there is a paucity of expertise, experience, and infrastructure in genomics and environmental research in SSA, to initiate and sustain such investigation. We seek to establish the Stroke Investigative Research and Education Network (SIREN) as a multidisciplinary collaborative research network of investigators in SSA and the United States collectively focused on exploring ways to promote a better understanding of the genetic and environmental risk factors for stroke among people of African ancestry. SIREN will evaluate unique contributors to stroke in SSA and compare these findings with those in a cohort of African American stroke survivors, all while simultaneously building sustainable capacities in phenomics, biobanking, genomics, biostatistics and bioinformatics for future high-level investigation of stroke and other vascular disease entities in SSA. SIREN is comprised of three interwoven Systematic Investigation of Blacks with Stroke (SIBS) projects geared at a comprehensive investigation of stroke: SIBS-Phenomics, SIBS-Genomics and SIBS-Bioinformatics. These projects will be implemented at eight sites in three countries (Nigeria, Ghana, and South Africa), and will leverage prior experience and ongoing collaborations including previous participation in a global stroke epidemiological study, and involvement in two current NIH- funded studies based in SSA. Input from renowned content experts in United States, where the societal burden of stroke has been successfully reduced through proper identification of risk factors and implementation of corresponding preventive strategies will be obtained through systematic network activities. Stroke Investigative Research and Education Network (SIREN)

虽然中风是一种离散的表型，但它是几种复杂和复杂疾病的临床顶点。 相互作用的生物过程，由各种遗传和环境因素沉淀，从而 这使得对其基本机制的分析成为一项挑战。然而， 成功的量身定制的预防战略，以减少巨大的个人和社会负担， 撒哈拉以南非洲（SSA）的中风取决于对诱发风险的更好理解 该地区的中风因素，这可能不一定符合中风危险因素的性质 在其他大陆的其他人中描述。事实上，中风的潜在危险因素， 撒南非洲迄今尚未得到全面的定性，目前缺乏 在基因组学和环境研究方面的专业知识、经验和基础设施， 并维持这样的调查 我们寻求建立中风调查研究和教育网络（SIREN）， SSA和美国的多学科合作研究网络 共同致力于探索促进更好地了解遗传和 非洲血统人群中风的环境危险因素。SIREN将评估独特的 SSA中卒中的贡献者，并将这些结果与非裔美国人队列中的结果进行比较。 中风幸存者，同时在表型组学，生物库， 基因组学、生物统计学和生物信息学，用于未来中风和其他疾病的高水平研究 SSA中的血管疾病实体。 SIREN由三个相互交织的黑人中风系统调查（SIBS）组成 针对中风的全面调查的项目：SIBS-Phenomics，SIBS-Genomics和 SIBS-Bioinformatics.这些项目将在三个国家（尼日利亚、 加纳和南非），并将利用先前的经验和正在进行的合作，包括 以前参与过一项全球卒中流行病学研究，并参与过两项目前的NIH- 资助的研究基于SSA。来自美国知名内容专家的意见， 通过正确识别风险因素， 将通过系统网络实施相应的预防战略 活动 中风调查研究和教育网络（SIREN）