Predicting Whole Brain Multi-Sensory Cognitive Control Networks: Relationship with Neuropsychological Test Performance and Repetitive Head Impact
预测全脑多感官认知控制网络:与神经心理学测试表现和重复头部冲击的关系
基本信息
- 批准号:9395139
- 负责人:
- 金额:$ 3.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-01 至 2019-09-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAmericanAnatomyAreaAttentionAuditoryAutopsyBehavioralBehavioral SymptomsBiological AssayBiological MarkersBoxingBrainCenters for Disease Control and Prevention (U.S.)ClinicalClinical TrialsCognitiveCognitive deficitsDataData ScienceData SetDepositionDevelopmentDiagnosisDiseaseDorsalExposure toFamily memberFingerprintFunctional Magnetic Resonance ImagingFutureGoalsImpairmentImpulsivityIndividualKnowledgeLaboratoriesLeadLifeLinkLocationLong-Term EffectsMachine LearningMagnetic Resonance ImagingMaintenanceManufactured footballMeasuresMethodsMilitary PersonnelModalityMonitorNerve DegenerationNeurocognitiveNeurodegenerative DisordersNeurologicNeuropsychological TestsNeuropsychologyOutcome MeasureParticipantPathologyPathway interactionsPatientsPatternPerformancePopulationProcessQuality of lifeRecording of previous eventsRecruitment ActivityReportingResearchResearch PersonnelResearch ProposalsRestRiskRugbiesScanningSeriesShort-Term MemorySiteSportsStagingStructureTauopathiesTestingTherapeutic InterventionTherapy trialTimeTrainingTranslatingTraumatic Brain InjuryVisualVisual attentionWorkbasebehavior observationchronic traumatic encephalopathycognitive abilitycognitive changecognitive controlcognitive neurosciencecohortcollegedesignexperienceexperimental studyfrontal lobehead impactimprovedin vivoinfancymultisensoryneurocognitive testneuroimagingnoveloutcome forecastperformance testspredictive modelingrelating to nervous systemresponseservice membersocial normspecific biomarkerssupport networktau Proteinstraining opportunity
项目摘要
PROJECT SUMMARY/ABSTRACT
Cognitive control is implicated in a number of higher-order cognitive abilities, including the allocation
and maintenance of attention, task switching and response selection. Individual ability to engage these
functions is variable, and deficits in these areas can lead to significantly diminished quality of life. Repetitive
head impacts (RHI) are linked to the development of chronic traumatic encephalopathy (CTE), a progressive
neurodegenerative disease characterized by aberrant tau protein deposition that currently can only be
diagnosed at autopsy. Individuals at risk for and later diagnosed with CTE often display deficits of cognitive
control that are observable behaviorally and via neurocognitive tests (NCT). Participants in high impact sports
(e.g., American football, boxing, rugby) and military service-members often experience a large number of
repetitive head impacts (RHI). The current lack of in vivo biomarkers to evaluate the long-term effects of RHI
severely impacts the ability of researchers and clinicians to monitor at risk individuals for the development and
progression of CTE. The research proposed herein aims to characterize the link between cognitive control
network function, normal and abnormal functional network connectivity and NCT performance, and whether
this is predictive of exposure to RHI. The proposed methods and hypotheses within this research proposal also
provide a valuable training opportunity.
Preliminary results from our laboratory demonstrate that a subject's functional connectivity fingerprint
can predict individual task fMRI activation. Furthermore, preliminary results in a dataset of retired NFL players
indicate aberrant functional connectivity within the dorsal attention and cognitive control networks. The
proposed series of studies will employ functional MRI (fMRI), resting state functional connectivity (RSFC), and
NCT to: 1) examine the relationship between cognitive control and attention fMRI activation, network RSFC
and the effect of RHI exposure; and 2) investigate the relationship between fMRI, functional connectivity and
diminished NCT performance in a population exposed to RHI. We propose to first study a group of healthy
control subjects to increase our knowledge of how the brain engages control processes in auditory and visual
attention tasks, and relate this to existing, well-accepted tests of attention and cognitive control. Subsequently,
we will investigate the relationship between diminished cognitive control processes and altered functional
connectivity in a population exposed to RHI. Our aim is to establish the predictive power of RSFC for individual
variability in the application of cognitive control processes in everyday life. Importantly, the successful
completion of this study will increase our understanding of long term effects of RHI on the brain's connectivity
and begin to formulate clinical profiles that may be used in the diagnosis and staging of CTE in vivo
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sean Michael Tobyne其他文献
Sean Michael Tobyne的其他文献
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{{ truncateString('Sean Michael Tobyne', 18)}}的其他基金
Development and validation of novel tests in the DCT drawing analysis platform for the detection of Alzheimer’s Disease-related early cognitive
在 DCT 绘图分析平台中开发和验证新测试,用于检测与阿尔茨海默病相关的早期认知
- 批准号:
10221367 - 财政年份:2020
- 资助金额:
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