Predicting Whole Brain Multi-Sensory Cognitive Control Networks: Relationship with Neuropsychological Test Performance and Repetitive Head Impact

预测全脑多感官认知控制网络：与神经心理学测试表现和重复头部冲击的关系

• 批准号: 9395139
• 负责人: Sean Michael Tobyne
• 金额: $ 3.23万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9395139
• 关键词: Age; American; Anatomy; Area; Attention; Auditory; Autopsy; Behavioral; Behavioral Symptoms; Biological Assay; Biological Markers; Boxing; Brain; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Trials; Cognitive; Cognitive deficits; Data; Data Science; Data Set; Deposition; Development; Diagnosis; Disease; Dorsal; Exposure to; Family member; Fingerprint; Functional Magnetic Resonance Imaging; Future; Goals; Impairment; Impulsivity; Individual; Knowledge; Laboratories; Lead; Life; Link; Location; Long-Term Effects; Machine Learning; Magnetic Resonance Imaging; Maintenance; Manufactured football; Measures; Methods; Military Personnel; Modality; Monitor; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; Neurologic; Neuropsychological Tests; Neuropsychology; Outcome Measure; Participant; Pathology; Pathway interactions; Patients; Pattern; Performance; Population; Process; Quality of life; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Research Proposals; Rest; Risk; Rugbies; Scanning; Series; Short-Term Memory; Site; Sports; Staging; Structure; Tauopathies; Testing; Therapeutic Intervention; Therapy trial; Time; Training; Translating; Traumatic Brain Injury; Visual; Visual attention; Work; base; behavior observation; chronic traumatic encephalopathy; cognitive ability; cognitive change; cognitive control; cognitive neuroscience; cohort; college; design; experience; experimental study; frontal lobe; head impact; improved; in vivo; infancy; multisensory; neurocognitive test; neuroimaging; novel; outcome forecast; performance tests; predictive modeling; relating to nervous system; response; service member; social norm; specific biomarkers; support network; tau Proteins; training opportunity

PROJECT SUMMARY/ABSTRACT Cognitive control is implicated in a number of higher-order cognitive abilities, including the allocation and maintenance of attention, task switching and response selection. Individual ability to engage these functions is variable, and deficits in these areas can lead to significantly diminished quality of life. Repetitive head impacts (RHI) are linked to the development of chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease characterized by aberrant tau protein deposition that currently can only be diagnosed at autopsy. Individuals at risk for and later diagnosed with CTE often display deficits of cognitive control that are observable behaviorally and via neurocognitive tests (NCT). Participants in high impact sports (e.g., American football, boxing, rugby) and military service-members often experience a large number of repetitive head impacts (RHI). The current lack of in vivo biomarkers to evaluate the long-term effects of RHI severely impacts the ability of researchers and clinicians to monitor at risk individuals for the development and progression of CTE. The research proposed herein aims to characterize the link between cognitive control network function, normal and abnormal functional network connectivity and NCT performance, and whether this is predictive of exposure to RHI. The proposed methods and hypotheses within this research proposal also provide a valuable training opportunity. Preliminary results from our laboratory demonstrate that a subject's functional connectivity fingerprint can predict individual task fMRI activation. Furthermore, preliminary results in a dataset of retired NFL players indicate aberrant functional connectivity within the dorsal attention and cognitive control networks. The proposed series of studies will employ functional MRI (fMRI), resting state functional connectivity (RSFC), and NCT to: 1) examine the relationship between cognitive control and attention fMRI activation, network RSFC and the effect of RHI exposure; and 2) investigate the relationship between fMRI, functional connectivity and diminished NCT performance in a population exposed to RHI. We propose to first study a group of healthy control subjects to increase our knowledge of how the brain engages control processes in auditory and visual attention tasks, and relate this to existing, well-accepted tests of attention and cognitive control. Subsequently, we will investigate the relationship between diminished cognitive control processes and altered functional connectivity in a population exposed to RHI. Our aim is to establish the predictive power of RSFC for individual variability in the application of cognitive control processes in everyday life. Importantly, the successful completion of this study will increase our understanding of long term effects of RHI on the brain's connectivity and begin to formulate clinical profiles that may be used in the diagnosis and staging of CTE in vivo

项目摘要/摘要 认知控制与许多高阶认知能力有关，包括分配 以及关注，任务切换和响应选择的维护。个人参与这些能力 功能是可变的，这些领域的缺陷可能会导致生活质量大大降低。重复 头部撞击（RHI）与慢性创伤性脑病（CTE）的发展有关 以异常Tau蛋白沉积为特征的神经退行性疾病目前只能是 在尸检时诊断。患有CTE和后来被诊断出患有CTE的人通常表现出认知不足 可以通过行为和通过神经认知测试（NCT）观察到的控制。参加高影响运动的参与者 （例如，美式足球，拳击，橄榄球）和兵役成员经常经历大量 重复的头部影响（RHI）。目前缺乏体内生物标志物来评估RHI的长期影响 严重影响研究人员和临床医生监视风险个人以进行开发的能力，并 CTE的进展。本文提出的研究旨在表征认知控制之间的联系 网络功能，正常和异常功能网络连接和NCT性能，以及是否是否 这可以预测暴露于RHI。本研究建议中提出的方法和假设也 提供宝贵的培训机会。 我们实验室的初步结果表明，受试者的功能连通性指纹 可以预测单个任务fMRI激活。此外，初步导致退休的NFL播放器数据集 表示背部注意力和认知控制网络中的功能连通性异常。这 拟议的一系列研究将采用功能性MRI（fMRI），静止状态功能连通性（RSFC）和 NCT至：1）检查认知控制与注意力FMRI激活，网络RSFC之间的关系 以及RHI暴露的影响； 2）研究fMRI，功能连接性和 暴露于RHI的人群中NCT的表现降低。我们建议先研究一组健康 控制对象，以增加我们对大脑如何在听觉和视觉中参与控制过程的了解 注意任务，并将其与现有的，充分接受的注意力和认知控制测试相关联。随后， 我们将研究认知控制过程减少和功能改变之间的关系 暴露于RHI的人群中的连通性。我们的目的是建立RSFC对个人的预测能力 认知控制过程在日常生活中的应用中的可变性。重要的是，成功 这项研究的完成将增加我们对RHI对大脑连通性的长期影响的理解 并开始制定可能用于诊断和分期的CTE体内临床特征