Tissue Level Deformations of the Loaded Spine in Humans with Low Back Pain

项目总结/摘要 候选人：候选人目前是华盛顿矫形外科助理教授 圣路易斯大学。他拥有博士学位。在生物医学工程，并已完成了国家卫生研究院 NRSA F32博士后奖学金研究基质金属蛋白酶-13在骨细胞介导的 骨稳态他的长期目标是发展成功的研究企业， 肌肉骨骼研究人员调查风险因素（如糖尿病和其他代谢因素）， 骨骼疾病的发病机制。该项目将为候选人提供一个 提高对腰痛的理解，以及设计、进行和协作人类活动的能力， 基于研究。该项目的完成预计将产生一个令人兴奋的和创新的研究 方向，使候选人能够开拓一个独立的利基，并定位他，以确保持续 校外资助 导师和咨询委员会：导师委员会由主要导师琳达货车迪伦博士领导， PT哲学博士、圣刘易斯的华盛顿大学的临床科学家。她是一个国际领导人， 下腰痛患者的测量和分类。其他导师包括萨姆·沃德博士，P.T.， 哲学博士、世界上使用开放式直立磁共振成像的先驱专家之一。 博士马修·席尔瓦博士，Julia & Walter Peterson骨科教授，在骨科领域拥有丰富的经验。 骨骼组织和生物力学成像，将建议图像处理，研究策略和职业生涯 发展洛里·塞顿博士Lucy & Stanley Lopata生物医学杰出教授 工程，将提供椎间盘机械生物学和生物力学的专业知识，以及职业生涯 开发和赠款写作。候选人还组建了一个顾问团队， Munish Gupta博士，医学博士（杰出的脊柱外科医生），以表彰他在临床表现方面的见解， 腰痛; Aseem Sharma博士，医学博士（神经放射学家）对退行性疾病分类的见解 脊柱结构; Kishan Yalavarthi博士，医学博士。（Open Upright的放射科医生和医疗主任） 密苏里州的MRI中心），他们将为序列优化和图像解释提供支持。 环境：候选人已获得至少1，500平方英尺的实验室空间（4，000平方英尺的共享空间） Silva博士和Dr. Alberopoulos实验室小组之间的空间）在肌肉骨骼研究中心（MRC - NIH P30 AR 057235）在圣刘易斯的华盛顿大学进行。他可以进入肌肉骨骼结构 和强度核心（其中唐博士还担任副主任）;原位分子分析核心; 和老鼠遗传学核心有14个肌肉骨骼研究实验室毗邻候选人的空间， 同一楼层利用开放空间形式，这使得大量资源和大量资源 共享货车Dillen博士指导的肌肉骨骼分析实验室，该实验室与Tang博士的 实验室和办公室。该实验室用于使用仪器测量测试受试者。实验室还 包括一个私人检查室。在这里，人们完成自我报告的措施，参加访谈， 测试使用临床措施，如我们的标准化临床检查，并改变他们的衣服， 为仪器化测试做准备。该实验室配备了一个三维的，基于视频的Vicon 运动捕捉系统配备8个MX-T40 2000 Hz红外摄像头。货车狄伦医生有一个承诺，从4 用于受试者招募的临床设施，所有设施均位于4444森林公园大楼附近 在那里进行检查和实验室测试。所有4个网站都是华盛顿的一部分 大学医学院，并与巴恩斯-犹太医院和华盛顿大学学院附属 医学门诊部。 培训计划：培训计划包括设计和执行以人为本的研究的实践培训 按照货车迪伦医生的指示教学培训包括临床研究培训中心的课程作业 包括伦理学、流行病学和成果研究课程。华盛顿大学提供了一个 学术丰富的环境，研讨会和协作互动。最后，定期与 导师博士席尔瓦，塞顿和沃德将指导职业发展和讨论结果。 研究：Tang博士将在非特异性低血压患者的同质亚组中检查负荷脊柱。 背痛，使用临床检查数据和运动学度量分类。随后，这些人将 使用开放式、直立式MRI和T2加权序列进行成像，以检查脊柱的变化， 加载和非加载状态。预计拟议的研究将确定变形的变化， 他们是如何改变的，他们是如何改变的。长期目标是定义多尺度临床 与LBP的临床检查结果和相关病理生理学相关的工具;并使用这些工具 研究结果，以指导临床和康复策略。 对候选人的机构承诺：候选人在该学院拥有终身教职 位于圣刘易斯的华盛顿大学骨科， 实验室、启动包和对工作人员/博士后的支持。

Project Summary/Abstract Candidate: The Candidate is currently an Assistant Professor in Orthopaedic Surgery at Washington University in St. Louis. He holds a Ph.D. in Biomedical Engineering and has previously completed a NIH NRSA F32 Postdoctoral Fellowship examining the role of Matrix Metalloprotease-13 in the osteocyte-mediated bone homeostasis. His long-term goal is to develop successful research enterprise as a translational musculoskeletal researcher to investigate the risk factors (such as diabetes and other metabolic factors) and the disease mechanisms of skeletal disorders. This proposed project would provide to the candidate an improved understanding of low back pain, as well as the ability to design, conduct, and collaborate on human- based studies. The completion of the project is expected to generate an exciting and innovative research direction to enable the Candidate to carve out an independent niche and position him to secure sustained extramural funding. Mentor and Advisory Committee: The mentoring committee is lead by primary mentor, Dr. Linda Van Dillen, P.T., Ph.D., a clinician-scientist at Washington University in St Louis. She is an international leader in the measurement and classification of people with low back pain. Other mentors include Dr. Sam Ward, P.T., Ph.D., one of the pioneering experts in the world in the use of Open, Upright Magnetic Resonance Imaging. Dr. Mathew Silva, Ph.D., Julia & Walter Peterson Professor in Orthopaedics, has extensive experience in the imaging of skeletal tissues and biomechanics, will advise on image processing, research strategies, and career development. Dr. Lori Setton, Ph.D. Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering, will provide expertise in intervertebral disc mechanobiology and biomechanics, as well as career development and grant writing. The candidate has also assembled a team of consultant to lend expertise to the project: Dr. Munish Gupta, M.D. (Distinguished spine surgeon) for his insights in clinical presentations of low back pain; Dr. Aseem Sharma, M.D. (neuroradiologist) for his insights in the degenerative classification of the spinal structures; and Dr. Kishan Yalavarthi, M.D. (radiologist and medical director for the Open Upright MRI Center of Missouri) who will provide support for sequence optimization and image interpretation. Environment: The candidate has been provided at least 1,500 sq ft of laboratory space (4,000 sq ft of shared space between the Dr. Silva and Dr. Thomopoulos lab groups) in the Musculoskeletal Research Center (MRC - NIH P30 AR057235) at Washington University in St Louis. He has access to the Musculoskeletal Structure and Strength Core (where Dr. Tang also serves as the Associate Director); In Situ Molecular Analysis core; and Mouse Genetics core. There are 14 musculoskeletal research labs adjacent to the candidate's space on the same floor utilizing an open space format, which enable substantial resource and substantial resource sharing. Dr. Van Dillen directs the Musculoskeletal Analysis Lab which is in close proximity to Dr. Tang's laboratory and office. The lab is used for testing of subjects with instrumented measures. The laboratory also includes a private examination room. Here people complete self-report measures, participate in interviews and testing using clinical measures, such as our standardized clinical examination, and change their clothes in preparation for instrumented testing. The laboratory is equipped with a 3-dimensional, video-based Vicon motion capture system with 8, MX-T40 2000 Hz infrared cameras. Dr. Van Dillen has a commitment from 4 clinical facilities for subject recruitment and all are located in close proximity to the 4444 Forest Park Building where examination and laboratory testing will take place. All 4 of the sites are a part of the Washington University School of Medicine and affiliated with the Barnes-Jewish Hospital and Washington University School of Medicine outpatient clinics. Training Plan: The training plan includes practical training in the design and execution of human-based studies as instructed by Dr. Van Dillen. Didactic training includes course work from Clinical Research Training Center and includes courses in ethics, epidemiology, and outcomes research. Washington University provides an academically rich environment for seminars and collaborative interactions. Finally, regular meetings with mentors Drs. Silva, Setton, and Ward will guide career development and discuss findings. Research: Dr. Tang will examine the loaded spine in homogenous subgroups of people with non-specific low back pain, classified using clinical examination data and kinematic metrics. Subsequently, these individuals will be imaged using the Open, Upright MRI with a T2-weighted sequence to examine changes in the spine during loaded and non-loaded states. The proposed studies are expected to identify the deformational changes of the loaded spine and how they are altered with LBP. The long-term objective is to define the multiscale clinical tools that relate clinical examination findings and the associated pathophysiology in LBP; and using these findings to guide clinical and rehabilitation strategies. Institutional Commitment to the Candidate: The Candidate holds a tenure-track faculty position in the Department of Orthopaedics at Washington University in St Louis, which has provided a newly renovated laboratory, start-up package, and support for staff/postdocs.