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The Utah Regional Network for Excellence in Neuroscience Clinical Trials

犹他州神经科学临床试验卓越区域网络

基本信息

批准号：
9293398
负责人：
John Robinson Singleton
金额：
$ 29.8万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-30 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9293398
关键词：
Academia Address Adult Affect Arizona Basic Science Biological Products Caring Child Childhood Cities Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Clinical Trials Network Collaborations Colorado Communities Complex Country Development Disease Education Ensure Environment Face Faculty Foundations Funding Goals Healthcare Hospitals Human Resources Human Subject Research Hydrocephalus Industry Institutional Review Boards International Knowledge Laboratories Leadership Medical center Mentors Mentorship Modeling Molecular Neurobiology Montana National Institute of Neurological Disorders and Stroke Nervous system structure Neurologic Neurologist Neurology Neuropathy Neuropsychology Neurosciences Neurosciences Research Nevada Patients Pediatric Neurology Performance Pharmacologic Substance Population Population Sciences Positioning Attribute Public Relations Rare Diseases Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Resources Site Sodium Chloride Spinal Training Training and Education Translational Research Translations United States Department of Veterans Affairs United States National Institutes of Health Universities Utah Validation base biomarker development biomedical referral center career development cost effective design education research epidemiology study experience faculty support health care delivery impaired glucose tolerance innovation interest medical schools member nervous system disorder neurosurgery novel novel therapeutics skills social media success therapeutic target trial design

项目摘要

DESCRIPTION (provided by applicant): In spite of unparalleled opportunities to assess novel therapies for both common and rare neurological disorders, investigators involved in multicenter clinical trials face an increasing array of challenges in efficiently designing, powering and performing such trials. The Network of Excellence in Neuroscience Clinical Trials (NEXT) is intended to help address this increasingly complex environment and facilitate an efficient robust mechanism for multicenter neuroscience trials via the creation of centralized infrastructure supporting a nationalized network of high quality sites and coordinating centers. Based at the University of Utah, the Utah Regional Network for Excellence in Neuroscience Clinical Trials (UR-NEXT) will provide an ideal mechanism for coordinating recruitment and access throughout a 5 state region in the Intermountain West. The coordinated efforts of a leadership team with a track record of collaboration and experience in both pediatric and adult clinical studies and trial and an experienced clinical trials manager will ensure the performance of high quality neuroscience trials across a broad range of diseases. The UR-NEXT will be centered at the University of Utah, where longstanding and close partnerships exist between the Clinical Neuroscience Center, the only integrated neuroscience center in a 5 state region, the Salt Lake City Veteran's Administration Medical Center, the western anchor for the Rocky Mountain Region, and Primary Children's Medical Center (PCMC), the leading pediatric referral center for the region. UR-NEXT will additionally benefit from an established network of referring community neurologists with interest in clinical trials, the Western Intermountain Neurological Organization (WINO), which has members ranging from southern Utah to Montana, and Nevada to western Colorado. The Neurology Department has sections in each major subspecialty and substantial expertise in the management and performance of both adult and pediatric multicenter clinical trials. The UR-NEXT will benefit from the Center for Clinical and Translational Science as well as numerous other collaborative resources. Overall, the network has primary access to a population of approximately 8 million covered lives, making it the ideal choice for a NEXT site for this region.

描述（由申请人提供）：尽管有无与伦比的机会来评估常见和罕见神经系统疾病的新疗法，但参与多中心临床试验的研究者在有效设计、支持和执行此类试验方面面临着越来越多的挑战。神经科学临床试验卓越网络（NEXT）旨在帮助解决这一日益复杂的环境，并通过创建支持高质量站点和协调中心的全国化网络的集中式基础设施，促进多中心神经科学试验的有效稳健机制。总部设在犹他州大学，犹他州区域网络卓越的神经科学临床试验（UR-NEXT）将提供一个理想的机制，协调招募和访问整个5个州的地区在山间西部。一个在儿科和成人临床研究和试验方面具有合作记录和经验的领导团队以及一位经验丰富的临床试验经理的协调努力将确保在广泛的疾病中进行高质量的神经科学试验。UR-NEXT将以犹他州大学为中心，该大学的临床神经科学中心是5个州地区唯一的综合神经科学中心，湖城军人管理局医疗中心是落基山脉地区的西部锚，初级儿童医疗中心（PCMC）是该地区领先的儿科转诊中心。UR-NEXT还将受益于一个由对临床试验感兴趣的社区神经学家组成的既定网络，即西部山间神经组织（WINO），该组织的成员范围从犹他州南部到蒙大拿州，从内华达州到科罗拉多西部。神经内科在每个主要的子专业都有科室，在成人和儿科多中心临床试验的管理和实施方面有大量的专业知识。UR-NEXT将受益于临床和转化科学中心以及许多其他合作资源。总体而言，该网络主要覆盖约800万人口，使其成为该地区NEXT站点的理想选择。