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Optimizing Treatment of Older Adults with Hypertension: A Net Benefit Analysis of Falls Injury vs Cardiovascular Outcomes

优化老年高血压患者的治疗：跌倒损伤与心血管结果的净效益分析

基本信息

批准号：
9250056
负责人：
Lillian Chiang Min
金额：
$ 32.88万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9250056
关键词：
Acute Adherence Adult Affect Age Ambulatory Care American Benefits and Risks Blood Pressure Cardiac Cardiovascular system Caring Cessation of life Characteristics Chronic Clinical Clinical Treatment Comorbidity Data Data Set Databases Diabetes Mellitus Disputes Elderly Electronic Health Record Event Fall injury Fright Future Goals Guidelines Health Health Status Health and Retirement Study Health system Healthcare Healthcare Systems Heart failure Hip Fractures Hypertension Hypotension Individual Injury Interview Joints Link Long-Term Care Measures Medical Medicare Medicare claim Methods Modeling Myocardial Infarction Outcome Patients Performance Pharmaceutical Preparations Population Prevalence Public Health Recommendation Reporting Research Risk Risk Reduction Severities Statistical Methods Stroke Taxonomy Testing Variant Veterans Work adverse outcome aggressive therapy arm blood pressure reduction blood pressure regulation cardiovascular disorder risk cardiovascular risk factor clinical practice common treatment control trial cost disorder risk epidemiology study fall risk falls functional decline health administration hypertension control improved innovation older patient patient oriented patient population population survey prevent public health relevance young adult

项目摘要

DESCRIPTION (provided by applicant): Every year, one in 10 older people fall and sustain injury requiring medical care. Fall-related injury is the number one cause of accidental death in older Americans. However, fall injury is rarely considered as a outcome in controlled trials, which have traditionally focused on death and cardiovascular events. Until recently, we lacked methods of capturing fall-related injury in large healthcare databases. We will first use the Health and Retirement Study, a national study of older Americans, to develop a method of classifying severe fall injury in found in Medicare claims data across acute, ambulatory, and long-term care (Aim 1). Next, we will study how a national healthcare system, the Veterans Health Administration (VHA), delivers aggressive hypertension care (AHC) and whether AHC results in net benefit or harm due to cardiovascular events and severe fall-related injury. Hypertension is the single most common chronic condition in older adults. Medication treatment prevents important cardiovascular events (strokes, myocardial infarctions and heart failure), however also contributes to risk of falls. We do not fully understand the net benefits and harms among our oldest patients in clinical practice, especially after age 75 - those most prone to severe fall-injury. Thus, we aim to study the net harms and benefits associated with AHC, defined as low blood pressure (BP, <130/65 mmHg) and prescribed =3 BP medications. We have demonstrated that the VHA, a national leader in hypertension care, has used performance measures to improve care but increased rates of AHC - especially among older Veterans. The average BP for those with AHC was 114/58 mmHg - lower than the aggressive treatment arm in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. A study that captures AHC, achieved BP, and falls injury is needed. Such a study is not possible anywhere except in the VHA. In the VHA, we have carefully used sophisticated electronic databases to identify the older patients with AHC. We will study whether certain types of VHA facilities are more likely to deliver AHC to their older patients (Aim 2), then test whether AHC increases short-term risk of injurious falls (Aim 3A). Last, we will compare whether net harm results from AHC when considering both severe fall-related injury and cardiovascular events (Aim 3B). This research will inform which patients and facilities should be targeted for future efforts to reduce AHC. Innovation. This research includes innovative methods of using claims data across acute, ambulatory, and long term care data and cutting-edge statistical methods of modeling multiple outcomes to determine whether the harm of AHC outweighs the benefit of cardiovascular event reduction. Impact. Optimizing risks and benefits of approaches to hypertensive care is patient-centered and has implications for the broader health and care of older adults. At the patient level, health care information about low benefit and potential harm is critical to make informed decisions. At the population level, improved methods of optimizing treatment targets can apply to broader clinical tradeoffs in older patient populations.