RECOGNITION OF APOPTOTIC AND NECROTIC CELLS BY THEIR PHAGOCYTES

吞噬细胞对凋亡和坏死细胞的识别

基本信息

  • 批准号:
    9244036
  • 负责人:
  • 金额:
    $ 29.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-10 至 2019-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): During animal development and in adulthood, cells undergoing apoptosis are rapidly internalized by other cells via phagocytosis (engulfment) and degraded inside phagocytes. The phagocytic removal of dying cells is an evolutionarily conserved process that has important physiological impact. The removal of apoptotic cells provides a safe means for eliminating unwanted and dangerous cells from the body. Furthermore, it prevents tissue injury, inflammatory responses, and auto-immune responses that could be induced by the content of dead cells. In addition, cells that die through necrosis, another type of cell death morphologically distinct from apoptosis and frequently caused by acute injury are also removed via phagocytosis. The removal of necrotic cells, which are associated with neurodegenerative disorders and stress responses, is considered critical for tissue regeneration. The study of the dying-cell removal process is also closely related to cancer research and treatment. My long-term objective is to understand the conserved molecular mechanism that controls the recognition, engulfment, and degradation of apoptotic cells, using the nematode Caenorhabditis elegans as a model organism. This proposal focuses on understanding the recognition of dying cells by engulfing cells, the first step of dying- cell removal. Dying cells expose "eat me" signal(s) on their outer surfaces to attract engulfing cells, which use cell-surface receptors to recognize the "eat me" signal(s) and initiate the engulfment process. A lot remains unknown about the mechanism that leads to the recognition of apoptotic cells by engulfing cells. Even less is known about how necrotic cells are recognized and removed from our bodies. We have previously identified C. elegans CED-1 as a phagocytic receptor for apoptotic cells. We have further found that phosphatidylserine (PS), a plasma membrane phospholipid, which is exposed on the outer surfaces of apoptotic cells, act as an "eat me" signal that attracts CED-1. This project investigates the molecular mechanisms leading to the exposure of PS by apoptotic and necrotic cells and the recognition of PS by CED-1 and a potential co-receptor of CED-1. Our work will identify common and different mechanisms that control the phagocytic recognition of necrotic and apoptotic cells, which die of different mechanisms. Furthermore, our work will shed light on novel mechanisms of cell-cell recognition and receptor activation during cell death and clearance.
描述(申请人提供):在动物发育和成体过程中,经历细胞凋亡的细胞通过吞噬(吞噬)被其他细胞迅速内化,并在吞噬细胞内降解。死亡细胞的吞噬清除是一个进化保守的过程,具有重要的生理影响。去除凋亡细胞为清除体内不需要的和危险的细胞提供了一种安全的方法。此外,它还可以防止组织损伤、炎症反应和自身免疫反应,这些反应可能是由死亡细胞的含量引起的。此外,在形态上与细胞凋亡不同的另一种类型的细胞死亡,通常是由急性损伤引起的细胞坏死,也通过吞噬作用被清除。坏死细胞的去除与神经退行性疾病和应激反应有关,被认为是组织再生的关键。死亡细胞去除过程的研究也与癌症的研究和治疗密切相关。我的长期目标是以线虫秀丽线虫为模式生物,了解控制凋亡细胞识别、吞噬和降解的保守分子机制。这项提议侧重于理解通过吞噬死亡细胞来识别死亡细胞,这是去除死亡细胞的第一步。濒临死亡的细胞在其外表面暴露“吃我”信号(S)以吸引吞噬细胞,吞噬细胞使用细胞表面受体识别“吃我”信号(S)并启动吞噬过程。对于通过吞噬细胞来识别凋亡细胞的机制,仍有许多未知之处。关于坏死细胞是如何被识别并从我们的身体中移除的,人们更是知之甚少。我们先前已经发现线虫CED-1是一种吞噬细胞凋亡的受体。我们进一步发现,暴露在凋亡细胞外表面的磷脂酰丝氨酸(PS)是一种质膜磷脂,它作为一种“吃我”的信号吸引CED-1。该项目研究了导致PS被凋亡和坏死细胞暴露的分子机制,以及CED-1和CED-1潜在的共同受体识别PS的分子机制。我们的工作将确定控制坏死和凋亡细胞吞噬识别的共同和不同机制,这两种细胞死于不同的机制。此外,我们的工作将阐明在细胞死亡和清除过程中细胞-细胞识别和受体激活的新机制。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
How are necrotic cells recognized by their predators?
坏死细胞如何被捕食者识别?
  • DOI:
    10.1080/21624054.2015.1120400
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Li,Zao;Zhou,Zheng
  • 通讯作者:
    Zhou,Zheng
Simultaneous Monitoring Cytoplasmic Calcium Ion and Cell Surface Phosphatidylserine in the Necrotic Touch Neurons of Caenorhabditis elegans.
同时监测秀丽隐杆线虫坏死接触神经元中的细胞质钙离子和细胞表面磷脂酰丝氨酸。
  • DOI:
    10.21769/bioprotoc.4187
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    Furuta,Yoshitaka;Zhou,Zheng
  • 通讯作者:
    Zhou,Zheng
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Zheng Zhou其他文献

Zheng Zhou的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Zheng Zhou', 18)}}的其他基金

How are necrotic neurons recognized by their phagocytes
坏死的神经元如何被吞噬细胞识别
  • 批准号:
    10564594
  • 财政年份:
    2022
  • 资助金额:
    $ 29.74万
  • 项目类别:
How are necrotic neurons recognized by their phagocytes
坏死的神经元如何被吞噬细胞识别
  • 批准号:
    10708976
  • 财政年份:
    2022
  • 资助金额:
    $ 29.74万
  • 项目类别:
Phagocytic Removal of Apoptotic and Necrotic Cells
吞噬去除凋亡和坏死细胞
  • 批准号:
    7993913
  • 财政年份:
    2010
  • 资助金额:
    $ 29.74万
  • 项目类别:
Phagocytic Removal of Apoptotic Cells
凋亡细胞的吞噬去除
  • 批准号:
    8515448
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Phagocytic Removal of Apoptotic and Necrotic Cells
吞噬去除凋亡和坏死细胞
  • 批准号:
    7526945
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Recognition of Apoptotic Cells for Their Phagocytosis
识别凋亡细胞的吞噬作用
  • 批准号:
    7223439
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Recognition of Apoptotic Cells for Their Phagocytosis
识别凋亡细胞的吞噬作用
  • 批准号:
    6743141
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Phagocytic Removal of Apoptotic and Necrotic Cells
吞噬去除凋亡和坏死细胞
  • 批准号:
    7678609
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Phagocytic Removal of Apoptotic Cells
凋亡细胞的吞噬去除
  • 批准号:
    8691866
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:
Recognition of Apoptotic Cells for Their Phagocytosis
识别凋亡细胞的吞噬作用
  • 批准号:
    7059483
  • 财政年份:
    2003
  • 资助金额:
    $ 29.74万
  • 项目类别:

相似海外基金

Un/kindness, shame & resistance: the care of inpatients in NHS adult acute mental health units and how it might be improved
Un/善良,羞耻
  • 批准号:
    2885806
  • 财政年份:
    2023
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Studentship
Post-Acute Care Transitions for Older Adult Medicare Beneficiaries with Serious Mental Illness
患有严重精神疾病的老年医疗保险受益人的急性后护理过渡
  • 批准号:
    10772386
  • 财政年份:
    2023
  • 资助金额:
    $ 29.74万
  • 项目类别:
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
  • 批准号:
    474619
  • 财政年份:
    2022
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Operating Grants
Investigating the impact acute inhalation of cannabis with a high content of delta-9-tetrahydrocannabinol has on myelination and microglia in adult and aged mice
研究急性吸入高含量 delta-9-四氢大麻酚的大麻对成年和老年小鼠髓鞘形成和小胶质细胞的影响
  • 批准号:
    485965
  • 财政年份:
    2022
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Studentship Programs
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
  • 批准号:
    466358
  • 财政年份:
    2022
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Operating Grants
Metabolomics for prediction of cisplatin mediated acute kidney injury: a Canadian multi-centre adult and pediatric study
预测顺铂介导的急性肾损伤的代谢组学:加拿大多中心成人和儿童研究
  • 批准号:
    402040
  • 财政年份:
    2019
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Operating Grants
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
  • 批准号:
    18K16103
  • 财政年份:
    2018
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Causal effect of time-varying driving pressures on mortality in mechanically ventilated, adult patients with acute respiratory distress syndrome
时变驱动压力对机械通气成年急性呼吸窘迫综合征患者死亡率的因果影响
  • 批准号:
    377313
  • 财政年份:
    2017
  • 资助金额:
    $ 29.74万
  • 项目类别:
    Studentship Programs
Role of SETBP1 in adult Ph+ acute lymphoblastic leukemia
SETBP1 在成人 Ph 急性淋巴细胞白血病中的作用
  • 批准号:
    9315111
  • 财政年份:
    2016
  • 资助金额:
    $ 29.74万
  • 项目类别:
Acute Inhibition of Adult-born Granule Cells and its Effect on Antidepressant Act
成体颗粒细胞的急性抑制及其抗抑郁作用
  • 批准号:
    8734273
  • 财政年份:
    2013
  • 资助金额:
    $ 29.74万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了