RR&D Research Career Scientist Award Application

RR

• 批准号: 9394573
• 负责人: JANIS J. DALY
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9394573
• 关键词: Accounting; Admission activity; Affect; Age; Aging; Area; Automobile Driving; Award; Biological Neural Networks; Biomechanics; Biomedical Engineering; Biophysics; Brain; Caring; Chemicals; Chronic; Clinical; Clinical Protocols; Cognitive; Collaborations; Development; Disabled Persons; Discipline; Electrical Engineering; Emotions; Environment; Equilibrium; Exercise; Exercise Physiology; Experimental Psychology; Florida; Funding; Funding Opportunities; Gait; Goals; Growth; Hand functions; Health; Healthcare; Healthcare Systems; Hospitals; Impairment; Individual; Injury; Institution; Intervention; Laboratories; Leadership; Life; Link; Measurement; Mentors; Methods; Mission; Motor; Multiple Sclerosis; Nervous System Trauma; Neurologist; Neurology; Neuronal Dysfunction; Neuronal Plasticity; Neurophysiology - biologic function; Neuropsychology; Neurosciences; Occupational Therapist; Occupational Therapy; Parkinson Disease; Pathology; Pattern; Performance; Physical therapy; Physics; Physiology; Pilot Projects; Population; Positioning Attribute; Productivity; Protocols documentation; Quality of life; Rehabilitation Centers; Rehabilitation Research; Rehabilitation therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Role; Scientist; Senior Scientist; Services; Societies; Spinal cord injury; Strategic Planning; Stroke; Talents; Testing; Training; Traumatic Brain Injury; Treatment Protocols; Universities; Upper Extremity; Veterans; Vision; arm; career; cognitive control; cost; disability; effective intervention; empowered; experience; fitness; improved; innovation; motor control; motor function recovery; motor learning; motor recovery; nervous system disorder; neuromuscular; neuroregulation; novel; physical therapist; prevent; programs; research and development; statistics; stroke survivor

Problem. Neurological disease and injury are major causes of disability, reflecting the need for more effective interventions. Additionally, accounting for the aging Veteran population, there is a projected 20% increase in disability for individuals age 85 and older, within the next 10 years. For example, approximately 6,000 VA annual admissions are for stroke, and at least 50% have serious, long term disability. Equally compelling statistics exist for traumatic brain injury (TBI) and other neurological diseases and injury. Research Activities and Overarching Goals. In strong support of the VHA Vision 2020 Strategic Plan and the RR&D mission, Dr. Daly is Director of the VA BRRC, whose mission is as follows: Discover mechanisms of pathology and impairment presenting obstacles to neural function, and generate innovative treatments to potentiate neural plasticity and neural network reorganization that will substantially improve motor, cognitive, and emotion function affected by neurologic disease or injury, sufficient to enhance quality of life and return to society and life role participation. To that end, Dr. Daly’s empowering BRRC leadership has attracted an interdisciplinary critical mass of electrical and biomedical engineers, biomechanists, neurologists, physical and occupational therapists, experimental and clinical neuropsychologists, exercise and neuromuscular physiologists, neuroscientists, and chemical and biophysicists. Significant discoveries have included information regarding the pathologies underlying neural dysfunction and innovative methods for restoring neural control of motor, cognitive, and emotion function for those with TBI, stroke, Parkinson’s disease, spinal cord injury, and multiple sclerosis. Supporting the VHA Mission and goals, and in addition to her BRRC leadership, Dr. Daly directs the Cognitive and Motor Learning Research Program, whose mission is to identify, engage, and restore the neural control that drives recovery of motor function in stroke survivors. Goals of currently ongoing studies are as follows: 1. Identify brain pattern changes that drive motor recovery. 2. Generate novel treatment methods that more accurately target pathology and impairment. 3. Apply motor learning principles that engage brain plasticity mechanisms allowing for productive practice of progressively more normal coordinated gait and upper limb function. 4. Generate and test treatment modules for gait components and upper limb function components. 5. Test gait and upper limb coordination treatment protocols in the clinical environment. Discoveries include the following: development and successful testing of a gait coordination training protocol that is clinically and statistically effective in chronic moderately impaired stroke survivors; successful feasibility pilot testing of a unique two-year care program for gait coordination, mobility, and fitness in stroke survivors; brain activation changes identified that drive upper limb motor recovery; development and successful testing of an upper limb function training protocol that is clinically and statistically effective in chronic moderately/severely impaired stroke survivors; necessary essential content of coordination training protocols includes long-duration, intensive coordination practice of finely incremental progression through a difficulty hierarchy.

问题。神经疾病和伤害是残疾的主要原因，反映了更多的需求 有效的干预措施。此外，考虑到老化的退伍军人人口，预计将有20％ 未来10年内，85岁及85岁以上个人的残疾增加。例如，大约 6,000名VA年度入学是中风的，至少50％的长期残疾患有严重的长期残疾。同样 存在引人注目的脑损伤（TBI）以及其他神经系统疾病和损伤的统计数据。 研究活动和总体目标。强烈支持VHA Vision 2020战略 计划和RR＆D任务，Daly博士是VA BRRC的主任，其任务如下：Discover 病理和障碍的机制呈现出神经功能的障碍，并产生创新 对潜在的神经元可塑性和神经元网络重组的处理，这将大大改善 受神经系统疾病或受伤影响的运动，认知和情感功能足以提高质量 生活和恢复社会和生活角色参与。为此，戴利博士的授权BRRC领导能力 吸引了电气和生物医学工程师，生物力学主义者，神经科医生的跨学科临界质量， 身体和占领的治疗师，实验和临床神经心理学家，运动和 神经肌肉生理学家，神经科学家以及化学和生物物理学家。大量发现 包括有关神经功能障碍和创新方法的病理的信息 为患有TBI，中风，帕金森氏症患者的电机，认知和情感功能的神经控制 疾病，脊髓损伤和多发性硬化症。 支持VHA的使命和目标，除了BRRC领导外，Daly博士还指导 认知和运动学习研究计划，其使命是识别，参与和恢复中立 控制驱动中风存活中运动功能的恢复。 目前正在进行的研究的目标如下： 1。确定大脑模式变化，以驱动运动恢复。 2。生成更准确靶向病理和损害的新型治疗方法。 3.应用运动原理，使大脑可塑性机制允许生产练习 逐渐正常的协调步态和上肢功能的逐渐。 4。生成和测试治疗模块，用于步态组件和上肢功能成分。 5。临床环境中的测试步态和上肢配位治疗方案。 发现包括以下内容：开发和成功测试会议协调培训 在临床和统计上有效的方案，可在长期受损的中风存活中；成功的 一项独特的两年护理计划的可行性试点测试，以实现中风的协调，机动性和健身 冲浪者；大脑激活变化确定驱动上肢运动恢复；发展和成功 测试上肢功能训练方案，该方案在临床和统计上有效 中度障碍的中风存活；协调培训协议的必要内容 包括长期的长期，通过困难的逐步进展的密集协调实践 等级制度。