RR&D Research Career Scientist Award Application

RR

• 批准号: 9394573
• 负责人: JANIS J. DALY
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9394573
• 关键词: Accounting; Admission activity; Affect; Age; Aging; Area; Automobile Driving; Award; Biological Neural Networks; Biomechanics; Biomedical Engineering; Biophysics; Brain; Caring; Chemicals; Chronic; Clinical; Clinical Protocols; Cognitive; Collaborations; Development; Disabled Persons; Discipline; Electrical Engineering; Emotions; Environment; Equilibrium; Exercise; Exercise Physiology; Experimental Psychology; Florida; Funding; Funding Opportunities; Gait; Goals; Growth; Hand functions; Health; Healthcare; Healthcare Systems; Hospitals; Impairment; Individual; Injury; Institution; Intervention; Laboratories; Leadership; Life; Link; Measurement; Mentors; Methods; Mission; Motor; Multiple Sclerosis; Nervous System Trauma; Neurologist; Neurology; Neuronal Dysfunction; Neuronal Plasticity; Neurophysiology - biologic function; Neuropsychology; Neurosciences; Occupational Therapist; Occupational Therapy; Parkinson Disease; Pathology; Pattern; Performance; Physical therapy; Physics; Physiology; Pilot Projects; Population; Positioning Attribute; Productivity; Protocols documentation; Quality of life; Rehabilitation Centers; Rehabilitation Research; Rehabilitation therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Role; Scientist; Senior Scientist; Services; Societies; Spinal cord injury; Strategic Planning; Stroke; Talents; Testing; Training; Traumatic Brain Injury; Treatment Protocols; Universities; Upper Extremity; Veterans; Vision; arm; career; cognitive control; cost; disability; effective intervention; empowered; experience; fitness; improved; innovation; motor control; motor function recovery; motor learning; motor recovery; nervous system disorder; neuromuscular; neuroregulation; novel; physical therapist; prevent; programs; research and development; statistics; stroke survivor

Problem. Neurological disease and injury are major causes of disability, reflecting the need for more effective interventions. Additionally, accounting for the aging Veteran population, there is a projected 20% increase in disability for individuals age 85 and older, within the next 10 years. For example, approximately 6,000 VA annual admissions are for stroke, and at least 50% have serious, long term disability. Equally compelling statistics exist for traumatic brain injury (TBI) and other neurological diseases and injury. Research Activities and Overarching Goals. In strong support of the VHA Vision 2020 Strategic Plan and the RR&D mission, Dr. Daly is Director of the VA BRRC, whose mission is as follows: Discover mechanisms of pathology and impairment presenting obstacles to neural function, and generate innovative treatments to potentiate neural plasticity and neural network reorganization that will substantially improve motor, cognitive, and emotion function affected by neurologic disease or injury, sufficient to enhance quality of life and return to society and life role participation. To that end, Dr. Daly’s empowering BRRC leadership has attracted an interdisciplinary critical mass of electrical and biomedical engineers, biomechanists, neurologists, physical and occupational therapists, experimental and clinical neuropsychologists, exercise and neuromuscular physiologists, neuroscientists, and chemical and biophysicists. Significant discoveries have included information regarding the pathologies underlying neural dysfunction and innovative methods for restoring neural control of motor, cognitive, and emotion function for those with TBI, stroke, Parkinson’s disease, spinal cord injury, and multiple sclerosis. Supporting the VHA Mission and goals, and in addition to her BRRC leadership, Dr. Daly directs the Cognitive and Motor Learning Research Program, whose mission is to identify, engage, and restore the neural control that drives recovery of motor function in stroke survivors. Goals of currently ongoing studies are as follows: 1. Identify brain pattern changes that drive motor recovery. 2. Generate novel treatment methods that more accurately target pathology and impairment. 3. Apply motor learning principles that engage brain plasticity mechanisms allowing for productive practice of progressively more normal coordinated gait and upper limb function. 4. Generate and test treatment modules for gait components and upper limb function components. 5. Test gait and upper limb coordination treatment protocols in the clinical environment. Discoveries include the following: development and successful testing of a gait coordination training protocol that is clinically and statistically effective in chronic moderately impaired stroke survivors; successful feasibility pilot testing of a unique two-year care program for gait coordination, mobility, and fitness in stroke survivors; brain activation changes identified that drive upper limb motor recovery; development and successful testing of an upper limb function training protocol that is clinically and statistically effective in chronic moderately/severely impaired stroke survivors; necessary essential content of coordination training protocols includes long-duration, intensive coordination practice of finely incremental progression through a difficulty hierarchy.

问题.神经系统疾病和损伤是残疾的主要原因，反映出需要更多的 有效干预。此外，考虑到老龄化的退伍军人人口，预计有20% 在未来10年内，85岁及以上的残疾人人数增加。例如大约 每年有6,000名退伍军人因中风入院，其中至少50%患有严重的长期残疾。同样 对于创伤性脑损伤（TBI）和其它神经疾病和损伤存在令人信服的统计数据。 研究活动和总体目标。大力支持VHA 2020愿景战略 计划和RR&D使命，戴利博士是VA BRRC的主任，其使命如下：发现 病理和损伤机制对神经功能造成障碍，并产生创新 增强神经可塑性和神经网络重组的治疗， 运动、认知和情感功能受神经系统疾病或损伤的影响，足以提高 回归社会和生活角色参与。为此，戴利博士赋予BRRC领导权， 吸引了大量跨学科的电气和生物医学工程师，生物力学家，神经学家， 物理和职业治疗师，实验和临床神经心理学家，运动和 神经肌肉生理学家，神经科学家，化学和生物药理学家。重大发现有 包括有关神经功能障碍的病理学和创新方法的信息， 恢复TBI、中风、帕金森病患者的运动、认知和情感功能的神经控制 疾病、脊髓损伤和多发性硬化症。 支持VHA使命和目标，除了她的BRRC领导，戴利博士指导 认知和运动学习研究计划，其使命是识别，参与，并恢复神经 控制，推动中风幸存者运动功能的恢复。 目前正在进行的研究的目标如下： 1.识别驱动运动恢复的大脑模式变化。 2.产生新的治疗方法，更准确地针对病理和损伤。 3.应用运动学习原理，使大脑可塑性机制允许生产性实践 步态和上肢功能逐渐变得更加正常。 4.生成并测试步态组件和上肢功能组件的治疗模块。 5.在临床环境中测试步态和上肢协调治疗方案。 发现包括以下内容：步态协调训练的开发和成功测试 在慢性中度受损卒中幸存者中临床和统计学有效的方案;成功 一项为期两年的独特中风患者步态协调、活动能力和健康护理计划的可行性试点测试 幸存者;大脑激活的变化，确定驱动上肢运动恢复;发展和成功 测试上肢功能训练方案，其在临床上和统计学上对慢性 中/重度脑卒中幸存者;协调训练方案的必要基本内容 包括长时间的、密集的协调练习，通过一个困难的精细渐进式进展， 等级制度。