Philips Achieva upgrade to support Connectome-compatible data acquisition
飞利浦 Achieva 升级以支持 Connectome 兼容的数据采集
基本信息
- 批准号:9274005
- 负责人:
- 金额:$ 60万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-01 至 2020-03-31
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAwardBlood VesselsBrainBrain imagingCardiacCharacteristicsChildClinicalDepositionDiagnostic ImagingDiffusionDiffusion Magnetic Resonance ImagingDiseaseElderlyFunctional Magnetic Resonance ImagingFundingGrantHealthHumanImageMagnetic Resonance ImagingMedical centerModalityNeurodegenerative DisordersNoisePopulationProtocols documentationResearchResearch ActivityResearch PersonnelResolutionResourcesSafetyScienceSignal TransductionSpectrum AnalysisSupervisionSystemTranslatingUnited States National Institutes of HealthUniversitiesWashingtonanatomic imagingbiological systemscognitive neuroscienceconnectomecostdata acquisitiondesigndigitalfetalimaging modalityinstrumentinterestmultimodalityneuroimagingoperationprogramsspatiotemporaltemporal measurementtransmission process
项目摘要
PROJECT SUMMARY
The overall purpose of this proposal is to upgrade a research-dedicated, Philips 3T Achieva MRI scanner at
the University of Washington Medical Center to support state of the art signal acquisition. The upgrade will
incorporate a digital signal transmission system, a multi-transmit system, and the Philips implementation of
simultaneous multislice (multi-band) acquisition. This upgrade will enable (i) a 15-40% increase in signal-to-
noise ratio, (ii) increased RF homogeneity and low RF power deposition, and (iii) high spatial and temporal
resolution for functional and anatomical imaging. Extensive neuroimaging research is conducted at this
scanner, especially with functional MRI and supporting modalities, Research activity also encompasses
cardiac MRI, fetal imaging, coil design and optimization, and advanced spectroscopy. The proposed upgrade
will benefit essentially all neuroimaging research, in humans and animals alike, through a fundamental
improvement in the fidelity (signal to noise characteristics) of the instrument. Imaging science has become
simply critical, and increasingly so, for understanding biological systems, detecting and controlling disease,
and translating basic discovery. The Diagnostic Imaging Science Center (DISC) and the closely partnered
Integrated Brain Imaging Center (IBIC) are the necessary and primary neuroimaging resources for NIH-funded
investigators at the University of Washington, who are interested in brain organization and function in health
and disease. The upgrade will enable them to advance multimodal (functional and diffusion connectivity,
vascular and structural MRI) imaging methods in clinical populations, including children and elders with
neurodegenerative diseases. Multiband acquisition will support superior spatiotemporal resolution in fMRI,
make multi-shell diffusion MRI feasible routinely, and enable Human Connectome Project- compatible data
acquisition protocols that are becoming a standard requirement for some cognitive neuroscience programs.
The scanner is housed at DISC and maintained under the supervision of expert MRI physicists and
technologists. We have outlined a detailed financial, technical, and safety plan for the smooth operation of the
scanner. Institutional commitment includes the differential costs required in excess of the grant award to
complete this upgrade.
项目摘要
本提案的总体目的是升级研究专用Philips 3 T Achieva MRI扫描仪,
华盛顿大学医学中心,以支持最先进的信号采集。升级将
结合了数字信号传输系统,多路传输系统,和飞利浦实现的
同时多片(多波段)采集。2这次升级将使(i)信号频率比增加15- 40%
噪声比,(ii)增加的RF均匀性和低RF功率沉积,以及(iii)高空间和时间
功能和解剖成像的分辨率。广泛的神经影像学研究是在这个
扫描仪,特别是功能性MRI和支持模式,研究活动还包括
心脏MRI、胎儿成像、线圈设计和优化以及高级光谱学。拟议的升级
将通过一个基本的,
提高仪器的保真度(信噪比)。成像科学已经成为
对于理解生物系统,检测和控制疾病,
诊断成像科学中心(DISC)和密切合作的
综合脑成像中心(IBIC)是NIH资助的必要和主要的神经影像资源
华盛顿大学的研究人员,他们对健康中的大脑组织和功能感兴趣
和疾病。升级将使他们能够推进多式联运(功能和扩散连接,
血管和结构MRI)成像方法,包括儿童和老年人,
多频带采集将支持fMRI中的上级时空分辨率,
使多层扩散MRI常规可行,并使人类连接组计划兼容的数据
采集协议正在成为一些认知神经科学项目的标准要求。
该扫描仪位于DISC,并在MRI物理学家专家的监督下进行维护,
技术专家。我们已经概述了一个详细的财务,技术和安全计划的顺利运作,
机构承诺包括超出赠款的差额费用,
完成此次升级。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas J. Grabowski其他文献
A Framework for the Administration of Anti-amyloid Monoclonal Antibody Treatments in Early-Stage Alzheimer’s Disease
- DOI:
10.1007/s40263-024-01097-w - 发表时间:
2024-06-05 - 期刊:
- 影响因子:7.400
- 作者:
Michael H. Rosenbloom;Tricia O’Donohue;Domi Zhou-Clark;Deepashni Mala;Andrew Frazier;Michael Tarrant;Michelle Modrijan;Melora Riveira;Darla Chapman;Yvonne Griffin;Lauren Shakalis;Thomas J. Grabowski - 通讯作者:
Thomas J. Grabowski
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
- DOI:
10.1186/s13059-025-03564-z - 发表时间:
2025-07-17 - 期刊:
- 影响因子:9.400
- 作者:
Farid Rajabli;Penelope Benchek;Giuseppe Tosto;Nicholas Kushch;Jin Sha;Katrina Bazemore;Congcong Zhu;Wan-Ping Lee;Jacob Haut;Kara L. Hamilton-Nelson;Nicholas R. Wheeler;Yi Zhao;John J. Farrell;Michelle A. Grunin;Yuk Yee Leung;Pavel P. Kuksa;Donghe Li;Eder Lucio da Fonseca;Jesse B. Mez;Ellen L. Palmer;Jagan Pillai;Richard M. Sherva;Yeunjoo E. Song;Xiaoling Zhang;Takeshi Ikeuchi;Taha Iqbal;Omkar Pathak;Otto Valladares;Dolly Reyes-Dumeyer;Amanda B. Kuzma;Erin Abner;Larry D. Adams;Perrie M. Adams;Alyssa Aguirre;Marilyn S. Albert;Roger L. Albin;Mariet Allen;Lisa Alvarez;Liana G. Apostolova;Steven E. Arnold;Sanjay Asthana;Craig S. Atwood;Sanford Auerbach;Gayle Ayres;Clinton T. Baldwin;Robert C. Barber;Lisa L. Barnes;Sandra Barral;Thomas G. Beach;James T. Becker;Gary W. Beecham;Duane Beekly;Bruno A. Benitez;David Bennett;John Bertelson;Thomas D. Bird;Deborah Blacker;Bradley F. Boeve;James D. Bowen;Adam Boxer;James Brewer;James R. Burke;Jeffrey M. Burns;Joseph D. Buxbaum;Nigel J. Cairns;Laura B. Cantwell;Chuanhai Cao;Christopher S. Carlson;Cynthia M. Carlsson;Regina M. Carney;Minerva M. Carrasquillo;Scott Chasse;Marie-Francoise Chesselet;Nathaniel A. Chin;Helena C. Chui;Jaeyoon Chung;Suzanne Craft;Paul K. Crane;David H. Cribbs;Elizabeth A. Crocco;Carlos Cruchaga;Michael L. Cuccaro;Munro Cullum;Eveleen Darby;Barbara Davis;Philip L. De Jager;Charles DeCarli;John DeToledo;Malcolm Dick;Dennis W. Dickson;Beth A. Dombroski;Rachelle S. Doody;Ranjan Duara;NIlüfer Ertekin-Taner;Denis A. Evans;Kelley M. Faber;Thomas J. Fairchild;Kenneth B. Fallon;David W. Fardo;Martin R. Farlow;Victoria Fernandez-Hernandez;Steven Ferris;Robert P. Friedland;Tatiana M. Foroud;Matthew P. Frosch;Brian Fulton-Howard;Douglas R. Galasko;Adriana Gamboa;Marla Gearing;Daniel H. Geschwind;Bernardino Ghetti;John R. Gilbert;Rodney C.P. Go;Alison M. Goate;Thomas J. Grabowski;Neill R. Graff-Radford;Robert C. Green;John H. Growdon;Hakon Hakonarson;James Hall;Ronald L. Hamilton;Oscar Harari;John Hardy;Lindy E. Harrell;Elizabeth Head;Victor W. Henderson;Michelle Hernandez;Timothy Hohman;Lawrence S. Honig;Ryan M. Huebinger;Matthew J. Huentelman;Christine M. Hulette;Bradley T. Hyman;Linda S. Hynan;Laura Ibanez;Gail P. Jarvik;Suman Jayadev;Lee-Way Jin;Kim Johnson;Leigh Johnson;M. Ilyas Kamboh;Anna M. Karydas;Mindy J. Katz;John S. Kauwe;Jeffrey A. Kaye;C. Dirk Keene;Aisha Khaleeq;Masataka Kikuchi;Ronald Kim;Janice Knebl;Neil W. Kowall;Joel H. Kramer;Walter A. Kukull;Frank M. LaFerla;James J. Lah;Eric B. Larson;Alan Lerner;James B. Leverenz;Allan I. Levey;Andrew P. Lieberman;Richard B. Lipton;Mark Logue;Oscar L. Lopez;Kathryn L. Lunetta;Constantine G. Lyketsos;Douglas Mains;Flanagan E. Margaret;Daniel C. Marson;Eden RR. Martin;Frank Martiniuk;Deborah C. Mash;Eliezer Masliah;Paul Massman;Arjun Masurkar;Wayne C. McCormick;Susan M. McCurry;Andrew N. McDavid;Stefan McDonough;Ann C. McKee;Marsel Mesulam;Bruce L. Miller;Carol A. Miller;Joshua W. Miller;Thomas J. Montine;Edwin S. Monuki;John C. Morris;Shubhabrata Mukherjee;Amanda J. Myers;Trung Nguyen;Thomas Obisesan;Sid O’Bryant;John M. Olichney;Marcia Ory;Raymond Palmer;Joseph E. Parisi;Henry L. Paulson;Valory Pavlik;David Paydarfar;Victoria Perez;Elaine Peskind;Ronald C. Petersen;Helen Petrovitch;Aimee Pierce;Marsha Polk;Wayne W. Poon;Huntington Potter;Liming Qu;Mary Quiceno;Joseph F. Quinn;Ashok Raj;Murray Raskind;Eric M. Reiman;Barry Reisberg;Joan S. Reisch;John M. Ringman;Erik D. Roberson;Monica Rodriguear;Ekaterina Rogaeva;Howard J. Rosen;Roger N. Rosenberg;Donald R. Royall;Marwan Sabbagh;A. Dessa Sadovnick;Mark A. Sager;Mary Sano;Andrew J. Saykin;Julie A. Schneider;Lon S. Schneider;William W. Seeley;Susan H. Slifer;Scott Small;Amanda G. Smith;Janet P. Smith;Joshua A. Sonnen;Salvatore Spina;Peter St George-Hyslop;Takiyah D. Starks;Robert A. Stern;Alan B. Stevens;Stephen M. Strittmatter;David Sultzer;Russell H. Swerdlow;Rudolph E. Tanzi;Jeffrey L. Tilson;John Q. Trojanowski;Juan C. Troncoso;Magda Tsolaki;Debby W. Tsuang;Vivianna M. Van Deerlin;Linda J. van Eldik;Jeffery M. Vance;Badri N. Vardarajan;Robert Vassar;Harry V. Vinters;Jean-Paul Vonsattel;Sandra Weintraub;Kathleen A. Welsh-Bohmer;Patrice L. Whitehead;Ellen M. Wijsman;Kirk C. Wilhelmsen;Benjamin Williams;Jennifer Williamson;Henrik Wilms;Thomas S. Wingo;Thomas Wisniewski;Randall L. Woltjer;Martin Woon;Clinton B. Wright;Chuang-Kuo Wu;Steven G. Younkin;Chang-En Yu;Lei Yu;Xiongwei Zhu;Brian W. Kunkle;William S. Bush;Akinori Miyashita;Goldie S. Byrd;Li-San Wang;Lindsay A. Farrer;Jonathan L. Haines;Richard Mayeux;Margaret A. Pericak-Vance;Gerard D. Schellenberg;Gyungah R. Jun;Christiane Reitz;Adam C. Naj - 通讯作者:
Adam C. Naj
Thomas J. Grabowski的其他文献
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