Life-course pathways linking adolescent childbearing to chronic conditions: A pilot study to reinforce research and health system capacity in Northeast Brazil

将青少年生育与慢性病联系起来的生命历程路径：一项旨在加强巴西东北部研究和卫生系统能力的试点研究

• 批准号: 9358371
• 负责人: SAIONARA M A CAMARA
• 金额: $ 15.55万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9358371
• 关键词: 17 year old; Academic Training; Address; Adolescence; Adolescent; Adult; Attitude; Biological; Biological Markers; Brazil; Budgets; Childbirth; Chronic; Chronic Disease; Chronic lung disease; Clinical; Collaborations; Communities; Country; Data; Development; Diabetes Mellitus; Disadvantaged; Discipline of Nursing; Disease; Doctor of Philosophy; Economics; Education; Elderly; Epidemiology; Ethics; Family; Fertility; Fostering; Foundations; Future; Gender; Generations; Geography; Health; Health Services; Health system; Hypertension; Income; Inequality; Institution; Interview; Knowledge; Laboratories; Latin America; Life; Life Cycle Stages; Link; Long-Term Effects; Low Birth Weight Infant; Measurement; Measures; Modification; Neonatal; Newborn Infant; Nurses; Outcome; Pathway interactions; Physical Function; Physical therapy; Physiological; Physiology; Pilot Projects; Policies; Population; Portuguese; Postpartum Period; Poverty; Pregnancy; Pregnancy Trimesters; Pregnancy in Adolescence; Pregnant Women; Premature Birth; Psychology; Public Health; Questionnaires; Reporting; Research; Research Infrastructure; Research Personnel; Retrospective Studies; Risk; Rural; Rural Community; Sampling; Scientific Advances and Accomplishments; Time; Training; Training and Infrastructure; United States; Universities; Woman; Women' s Health; child bearing; cohort; cultural values; disability; epidemiology study; evidence base; girls; health care service; higher education; improved; innovation; international partnership; middle age; next generation; older women; pregnant; pregnant teen; programs; prospective; psychologic; public health intervention; reproductive; research study; social; social norm; socioeconomics; student training; systems research; unintended pregnancy; urban area; young woman

Project Summary: This project has two principal objectives: 1) Improve health system and research capacity in the community of Santa Cruz, which is located in the region of Northeast Brazil and 2) Apply that capacity in order to conduct epidemiological research investigating pathways that may explain how and why adolescent childbirth is associated to chronic conditions and mobility loss in middle-aged and older women. Such information is vital to developing preventative public health interventions to address non-communicable diseases across the life-course. Lessons learned from this research would add to the research evidence-base for policy and action on adolescent pregnancy and, more broadly, women's health in Latin America. Specifically, this project aims to: 1) Train students from the Santa Cruz campus of the Federal University of Rio Grande do Norte (Brazil) to conduct epidemiological interviews, collect biological samples, and take anthropometric and clinical measures. It will also provide in-depth, specialized training on ethical research conduct when working with pregnant and adolescent women; 2) Develop and validate epidemiological questionnaires adapted to a low-education, rural, adolescent, Portuguese-speaking population; 3) Prospectively follow a pilot cohort of adolescent and adult women, pregnant for the first time, from the 1st trimester of pregnancy to 6-weeks postpartum. This pilot would collect questionnaire data (baseline), clinical measurements, and biomarker concentrations (baseline, 3rd trimester, 6-weeks postpartum). The proposed pilot study, which is the 3rd study aim, will lay the foundation for a more expansive and comprehensive research program investigating hypothesized mechanisms behind previously documented associations between adolescent childbirth and poor later-life health. Overall, the capacity built and sustained from this project will contribute to advancing health research in one of the most underserved regions of Brazil. It will provide training to the next generation of Brazilian researchers and establish long-term networks between Brazilian and United States researchers.

项目概述：本项目有两个主要目标：1)改善卫生系统和研究能力