Life-course pathways linking adolescent childbearing to chronic conditions: A pilot study to reinforce research and health system capacity in Northeast Brazil

将青少年生育与慢性病联系起来的生命历程路径：一项旨在加强巴西东北部研究和卫生系统能力的试点研究

• 批准号: 9232027
• 负责人: SAIONARA M A CAMARA
• 金额: $ 16.59万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232027
• 关键词: 17 year old; Academic Training; Address; Adolescence; Adolescent; Adult; Attitude; Biological; Biological Markers; Brazil; Budgets; Childbirth; Chronic; Chronic Disease; Chronic lung disease; Clinical; Collaborations; Communities; Country; Data; Development; Diabetes Mellitus; Disadvantaged; Discipline of Nursing; Disease; Doctor of Philosophy; Economics; Education; Elderly; Epidemiologic Studies; Epidemiology; Ethics; Family; Fertility; Fostering; Foundations; Future; Gender; Generations; Health; Health Services; Health system; Hypertension; Income; Inequality; Institution; Interview; Knowledge; Laboratory Research; Latin America; Learning; Life; Life Cycle Stages; Link; Long-Term Effects; Low Birth Weight Infant; Measurement; Measures; Modification; Neonatal; Newborn Infant; Outcome; Pathway interactions; Physical Function; Physical therapy; Physiological; Physiology; Pilot Projects; Policies; Population; Portuguese; Postpartum Period; Poverty; Pregnancy; Pregnancy Trimesters; Pregnancy in Adolescence; Pregnant Women; Premature Birth; Psychology; Public Health; Questionnaires; Reporting; Research; Research Infrastructure; Research Personnel; Retrospective Studies; Risk; Rural; Rural Community; Sampling; Scientific Advances and Accomplishments; Time; Training; Training and Infrastructure; United States; Universities; Woman; Women' s Health; Work; child bearing; cohort; cultural values; disability; evidence base; girls; health care service; higher education; improved; innovation; international partnership; middle age; next generation; older women; pregnant; pregnant teen; programs; psychologic; public health intervention; reproductive; research study; social; social norm; socioeconomics; student training; systems research; unintended pregnancy; urban area; young woman

Project Summary: This project has two principal objectives: 1) Improve health system and research capacity in the community of Santa Cruz, which is located in the region of Northeast Brazil and 2) Apply that capacity in order to conduct epidemiological research investigating pathways that may explain how and why adolescent childbirth is associated to chronic conditions and mobility loss in middle-aged and older women. Such information is vital to developing preventative public health interventions to address non-communicable diseases across the life-course. Lessons learned from this research would add to the research evidence-base for policy and action on adolescent pregnancy and, more broadly, women's health in Latin America. Specifically, this project aims to: 1) Train students from the Santa Cruz campus of the Federal University of Rio Grande do Norte (Brazil) to conduct epidemiological interviews, collect biological samples, and take anthropometric and clinical measures. It will also provide in-depth, specialized training on ethical research conduct when working with pregnant and adolescent women; 2) Develop and validate epidemiological questionnaires adapted to a low-education, rural, adolescent, Portuguese-speaking population; 3) Prospectively follow a pilot cohort of adolescent and adult women, pregnant for the first time, from the 1st trimester of pregnancy to 6-weeks postpartum. This pilot would collect questionnaire data (baseline), clinical measurements, and biomarker concentrations (baseline, 3rd trimester, 6-weeks postpartum). The proposed pilot study, which is the 3rd study aim, will lay the foundation for a more expansive and comprehensive research program investigating hypothesized mechanisms behind previously documented associations between adolescent childbirth and poor later-life health. Overall, the capacity built and sustained from this project will contribute to advancing health research in one of the most underserved regions of Brazil. It will provide training to the next generation of Brazilian researchers and establish long-term networks between Brazilian and United States researchers.

项目概要：本项目有两个主要目标：1）改善卫生系统和研究能力 在位于巴西东北部地区的圣克鲁斯社区，以及2）将这种能力应用于 为了进行流行病学研究，调查可能解释青少年如何以及为什么 生育与中老年妇女的慢性病和丧失行动能力有关。等 信息对于制定预防性公共卫生干预措施以应对非传染性疾病至关重要 疾病贯穿生命历程。从这项研究中吸取的经验教训将增加研究的证据基础 在拉丁美洲，青少年怀孕和更广泛的妇女健康问题的政策和行动。 具体而言，该项目旨在：1）培训里约联邦大学圣克鲁斯校区的学生 Grande do Norte（巴西）进行流行病学访谈，收集生物样本， 人体测量和临床测量。它还将提供关于伦理研究的深入、专门培训 2）制定和验证流行病学 适合教育程度低、农村、青少年、葡萄牙语人口的调查问卷; 3） Prostitution跟踪了一组青少年和成年女性的试点队列，这些女性从第一次怀孕开始， 怀孕三个月至产后6周。该试点将收集问卷数据（基线）、临床 测量值和生物标志物浓度（基线、妊娠晚期、产后6周）。拟议 试点研究，这是第三个研究目标，将奠定基础，更广泛和全面的 一项研究计划，调查先前记录的关联背后的假设机制 青春期分娩和晚年健康状况之间的关系。总的来说，由此建立和维持的能力 该项目将有助于推进巴西最缺乏服务的地区之一的卫生研究。它将 为下一代巴西研究人员提供培训，并建立长期网络， 巴西和美国的研究人员。