Novel Quantitative Vascular Functional Magnetic Resonance Imaging of Oxycodone Addiction and Response

项目总结。 磁共振成像(MRI)是研究大脑及其功能的最有用的工具之一。 流程。然而，许多脑成像技术受到核磁共振信号的复杂性的限制 使生物参数的量化变得困难。我们实验室开发的一种名为Qute-CE MRI的技术， 已被证明可以提供纳米颗粒浓度的高分辨率定量成像。从长远来看 这项研究的目标是开发一种功能脑成像模式，可能对两种基础疾病都有用 神经科学研究和临床应用。此特定项目的目标是测量绝对 羟考酮用药和成瘾前后脑血管的数量变化。这 目标将通过执行两个具体目标来实现；(1)将QUTE-CE MRI应用于功能 成像(FMRI)，以创建定量的功能性脑血容量(CBV)扫描。这将需要有能力 量化纳米颗粒浓度并使用它来量化每个区域的血液量的技术 基于已知血液中纳米粒子的浓度，改进了我所做的工作 已经为之前发表过。(2)通过慢性评估将该技术应用于药物成瘾问题 从羟考酮给药到CBV的急性区域性变化。大脑的动态血管系统 根据活动的变化分配血液，利用这项技术，我们可能能够绝对量化 这些动态变化具有前所未有的准确性。血管组织必须解决共同的 大脑活动的模式，我们假设长期接触药物的吸毒者 可能对他们的血管系统有潜在的代偿性变化。这个项目是创新的，因为 这项技术为脑成像提供了一种新的方式。它具有重要意义，因为它可能会提供新的信息 关于羟考酮成瘾和反应的过程，这项技术只使用标准的MRI设备 与FDA批准的纳米颗粒注射相结合，从而可以轻松地转化为临床扫描，以及 已知的各种疾病都有可以研究的血管异常(和潜在的 诊断)通过这种技术。

PROJECT SUMMARY. Magnetic resonance imaging (MRI) is one of the most useful tools available in the study of the brain and its processes. However, many brain imaging techniques are limited by the complexities of the MRI signal which make quantification of biological parameters difficult. A technique developed in our lab, called QUTE-CE MRI, has been shown to provide high resolution quantitative imaging of nanoparticle concentration. The long term goal of this research is to develop a functional brain imaging modality that may be useful for both basic neuroscience research and clinical applications. The objective of this specific project is to measure absolute quantitative changes to brain vasculature before and after oxycodone administration and addiction. This objective will be accomplished via execution of two specific aims; (1) Apply QUTE-CE MRI to functional imaging (fMRI) to create quantitative functional cerebral blood volume (CBV) scans. This will take the ability of the technique to quantify nanoparticle concentration and use it to quantify the amount of blood in each region of the brain based on a known blood concentration of the nanoparticles, improving on the work that I have been published for previously. (2) Apply the technique to the problem of drug addiction by evaluating chronic and acute regional changes in CBV to oxycodone administrations. The vasculature of the brain dynamically allocates blood in response to changes in activity, with this technique we may be able to absolutely quantify these dynamic changes with unprecedented accuracy. Vascular organization must address the common patterns of brain activity activity and we hypothesize that addicts who have chronically been exposed to a drug may have underlying compensatory changes to their vasculature. This project is innovative because the technique provides a new modality for brain imaging. It is significant because it may give new information about the process of addiction and response to oxycodone, the technique uses only standard MRI equipment combined with an FDA approved nanoparticle injection so it could easily be translated to clinical scans, and a wide variety of diseases are known to have vascular abnormalities which could be studied (and potentially diagnosed) via this technique.