CDP-choline treatment in amphetamine type stimulant-using adolescents
CDP-胆碱治疗安非他明类兴奋剂青少年
基本信息
- 批准号:9468363
- 负责人:
- 金额:$ 46.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-15 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAdolescentAdultAmphetaminesAttentionAwardBehaviorBehavioralBiologicalBrainBrain regionCholineClinicalClinical TrialsCognitiveCognitive TherapyCognitive deficitsCollaborationsCytidineCytidine Diphosphate CholineDataDiffusion Magnetic Resonance ImagingDiphosphatesDrug AddictionDrug PrescriptionsDrug abuseExecutive DysfunctionFoodFundingHealthHigh School StudentHumanImageImage AnalysisInstitutesInternationalKnowledgeMembraneMethamphetamineMolecularMolecular TargetMonitorMultimodal ImagingNIH Program AnnouncementsNeuronsNeuropsychological TestsOutcome MeasureParticipantPathway AnalysisPatient Self-ReportPerformancePharmaceutical PreparationsPhospholipidsPlacebosPopulationPrefrontal CortexPropertyRandomizedReportingResearchResearch ProposalsResourcesScientistSiteSouth KoreaSystemThickTreatment EfficacyUniversitiesUrineUtahamphetamine usebasebrain abnormalitiescell injurycollegedouble-blind placebo controlled trialexecutive functionglobal healthgray matterimprovedinorganic phosphatemagnetic resonance spectroscopic imagingmethamphetamine effectmethamphetamine usemethamphetamine usermultimodalitymyelinationnamed groupneural circuitneuroimagingneurotoxicitynonmedical usenovelprogramspublic health relevancerecruitrepairedstimulant usesuccesssymptomatic improvementsynthetic drugtreatment strategytrendwhite matter
项目摘要
DESCRIPTION (provided by applicant): The increased use of amphetamine-type stimulants (ATS), which refer to the group of stimulants including methamphetamine (MA) and amphetamine, has become a major global health problem in recent years. There is also an increasing concern about the high rate of the non-medical use of prescription stimulants among adolescents. In this competing renewal of DA024070, an international collaborative study aimed to determine the effects of MA on the developing brain, we propose to extend our studies in ATS-using adolescents to evaluate a novel treatment strategy for this population. On the basis of preliminary findings identifying adolescent-specific brain and cognitive vulnerability to stimulant exposure and the neuroprotective properties of cytidine-5'-diphosphate choline (CDP-choline), we propose to conduct a 12-week, randomized, double-blind, placebo-controlled trial of CDP-choline in ATS-using adolescents. As outcome measures, multi-level assessments will be performed at molecular, neural circuitry, cognitive, and clinical levels. It will be determined whether CDP-choline administration, compared to placebo administration, will 1) repair ATS-induced neural cell damage within the target brain regions, which will be assessed using multinuclear magnetic resonance spectroscopic imaging, 2) improve cognitive deficits and normalize the relevant target neural circuits, which will be assessed using neuropsychological tests and multimodal imaging analyses including cortical thickness analysis, diffusion tensor imaging analysis, and network analysis, and 3) reduce ATS-taking behaviors, which will be assessed using a combination of urine monitoring and self-report of ATS use. This study will demonstrate that CDP-choline engages the treatment target and thereby provides clinical benefits to ATS-using adolescents. In the context of the unique opportunity to recruit a special population, such as ATS-using adolescents, in Seoul, South Korea, this project will be performed based on the international collaboration between Perry F. Renshaw at the Brain Institute, the University of Utah, UT, USA and In Kyoon Lyoo at the Ewha Brain Institute, Ewha W. University, Seoul, South Korea. We believe that this research proposal is highly responsive to the International Research Collaboration on Drug Abuse and Addiction Research Program Announcement (PA-12- 040) that encourages the utilization of unique resources or subject populations which would otherwise be difficult to access domestically. As is also acknowledged in the '2007 Distinguished International Scientist Collaboration Award' and '2008 International Program Award for Excellence [Collaborative Research]', our well established collaboration will contribute to the success of this proposal.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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In Kyoon Lyoo其他文献
In Kyoon Lyoo的其他文献
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{{ truncateString('In Kyoon Lyoo', 18)}}的其他基金
Longitudinal neuroimaging of metamphetamine-dependent adolescents
甲基苯丙胺依赖青少年的纵向神经影像学
- 批准号:
7527909 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
Longitudinal neuroimaging of metamphetamine-dependent adolescents
甲基苯丙胺依赖青少年的纵向神经影像学
- 批准号:
7880750 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
Longitudinal neuroimaging of metamphetamine-dependent adolescents
甲基苯丙胺依赖青少年的纵向神经影像学
- 批准号:
8104227 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
Longitudinal neuroimaging of metamphetamine-dependent adolescents
甲基苯丙胺依赖青少年的纵向神经影像学
- 批准号:
8279384 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
Longitudinal neuroimaging of metamphetamine-dependent adolescents
甲基苯丙胺依赖青少年的纵向神经影像学
- 批准号:
7684040 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
CDP-choline treatment in amphetamine type stimulant-using adolescents
CDP-胆碱治疗安非他明类兴奋剂青少年
- 批准号:
9246451 - 财政年份:2008
- 资助金额:
$ 46.28万 - 项目类别:
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