Discriminating sex chromosome and hormonal effects on brain sexual dimorphisms
Discriminating sex chromosome and hormonal effects on brain sexual dimorphisms
批准号:
9376919
负责人:
Arthur P Arnold
金额:
$23.28万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-01 至 2019-08-31
关键词:
AdultAffectAnatomyAneuploidyAreaAtlasesBrainBrain regionCell SizeCellsCerebellar cortex structureCerebral cortexChromosomesCollaborationsCorpus CallosumDevelopmentDiseaseExperimental DesignsFemaleFimbria of hippocampusFoundationsGenesGenotypeGoalsGonadal HormonesGonadal Steroid HormonesGonadal structureHormonalHormonesImage AnalysisIncidenceIndividualInequalityLeadMagnetic Resonance ImagingMeasurementMeasuresMediatingMental disordersModelingModernizationMolecularMusOccipital lobeOutcomeOvarianOvaryPatternPhenotypePopulationReproductionResearchSafe SexSex BiasSex CharacteristicsSex ChromosomesSiteStructureTechniquesTestisWomanX ChromosomeY Chromosomebasebrain cellbrain morphologybrain sizebrain volumedensityexperimental studygray matterimaging studymalemenmorphometrymouse modelmultilevel analysisnervous system disorderneuroprotectionneuropsychiatric disordernovelnovel therapeuticsrelating to nervous systemsexsexual dimorphismtheories
中文摘要
项目概要/摘要
男性和女性表现出不同的发病率和模式的神经和精神
疾病,表明一种性别可能拥有更高水平的因素,保护免受
疾病,或降低加剧疾病的因素水平。的长期目标
该项目旨在确定哪些大脑区域受到性别偏见因素的影响,例如
由性染色体编码的基因和性腺激素的水平,
成年因为这些类型的性别偏见保护是由不同的
分子机制,区分每个因素的作用位点是第一步
了解性别偏见保护是如何运作的拟议研究
包括全脑磁共振成像来测量每个大脑的大小
在特定的性别偏见因素可以严格限制的条件下,
观察它们各自的效果。性染色体非整倍体的脑
和野生型(XO、XX、XY和XXY)将在小鼠具有或不具有
它们的生殖腺实验设计将确定哪些性别差异在体积
大脑区域的数量受到X染色体数量的影响,
缺乏Y染色体,以及睾丸和卵巢分泌物的水平,
成年研究结果将建立大脑区域和局部功能,
受到不同性别偏见机制的影响。结果将改变概念
研究受影响脑区保护机制的框架
神经和精神疾病。
英文摘要
Project Summary / Abstract
Men and women show different incidence and patterns of neurological and psychiatric
diseases, indicating that one sex may possess higher levels of factors that protect from
disease, or lower levels of factors that exacerbate disease. The long-term goal of the
project is to determine which brain regions are influenced by sex-biasing factors such as
the genes encoded by the sex chromosomes and the level of gonadal hormones in
adulthood. Because these types of sex-biased protection are mediated by different
molecular mechanisms, discriminating the sites of action of each factor is the first step
towards understanding how sex-biased protection operates. The proposed research
involves whole-brain magnetic resonance imaging to measure the size of every brain
region, under conditions in which specific sex-biasing factors can be rigorously
manipulated to observe their individual effects. The brains of sex chromosome aneuploid
and wild-type (XO, XX, XY and XXY) will be compared when mice have or do not have
their gonads. The experimental design will determine which sex differences in volumes
of brain regions are influenced by the number of X chromosomes, and by the presence /
absence of the Y chromosome, and by the levels of testicular and ovarian secretions in
adulthood. The results will establish the brain regions and localized functions that are
influenced by different sex-biasing mechanisms. The outcome will alter conceptual
frameworks for investigating protective mechanisms in brain regions affected by
neurological and psychiatric disease.
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科研奖励(0)
会议论文
Transformative rat models to study sex differences in disease
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批准号:10426101
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项目类别:
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资助金额:$55.41万
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财政年份:2021
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负责人:Arthur P Arnold
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依托单位:
Transformative rat models to study sex differences in disease
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批准号:10180448
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项目类别:
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资助金额:$60.74万
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财政年份:2021
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负责人:Arthur P Arnold
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依托单位:
Transformative rat models to study sex differences in disease
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批准号:10596153
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项目类别:
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资助金额:$56.71万
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财政年份:2021
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负责人:Arthur P Arnold
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依托单位:
Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain
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批准号:10360528
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项目类别:
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资助金额:$48.52万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meetings
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批准号:10355494
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meetings
-
批准号:10026263
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meetings
-
批准号:10569018
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meetings
-
批准号:10113549
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain
-
批准号:10553728
-
项目类别:
-
资助金额:$43.5万
-
财政年份:2020
-
负责人:Arthur P Arnold
-
依托单位:
Career Enhancement Core
-
批准号:10713762
-
项目类别:
-
资助金额:$11.29万
-
财政年份:2018
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负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meeting
-
批准号:10656223
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项目类别:
-
资助金额:$2.5万
-
财政年份:2017
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meeting
-
批准号:10441278
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2017
-
负责人:Arthur P Arnold
-
依托单位:
Organization for the Study of Sex Differences Annual Meeting
-
批准号:10213602
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2017
-
负责人:Arthur P Arnold
-
依托单位:
Epigenetic regulation of myocardial ischemia/reperfusion injury by X chromosome
-
批准号:9262978
-
项目类别:
-
资助金额:$38.5万
-
财政年份:2016
-
负责人:Arthur P Arnold
-
依托单位:
Genetic Mechanisms in Klinefelter Syndrome-Related Behaviors
-
批准号:8856295
-
项目类别:
-
资助金额:$41.65万
-
财政年份:2014
-
负责人:Arthur P Arnold
-
依托单位:
Sex differences in myocardial ischemia/reperfusion injury
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批准号:8712076
-
项目类别:
-
资助金额:$35.0万
-
财政年份:2014
-
负责人:Arthur P Arnold
-
依托单位:
Sex differences in obesity and metabolic disease
-
批准号:8442933
-
项目类别:
-
资助金额:$30.53万
-
财政年份:2010
-
负责人:Arthur P Arnold
-
依托单位:
Sex differences in obesity and metabolic disease
-
批准号:7985124
-
项目类别:
-
资助金额:$38.5万
-
财政年份:2010
-
负责人:Arthur P Arnold
-
依托单位:
Sex differences in obesity and metabolic disease
-
批准号:8639549
-
项目类别:
-
资助金额:$31.64万
-
财政年份:2010
-
负责人:Arthur P Arnold
-
依托单位:
Sex differences in obesity and metabolic disease
-
批准号:8092480
-
项目类别:
-
资助金额:$31.64万
-
财政年份:2010
-
负责人:Arthur P Arnold
-
依托单位:
海外基金