HIV intervention models for criminal justice involved substance-using Black MSM

刑事司法的艾滋病毒干预模型涉及使用药物的黑人男男性接触者

• 批准号: 9480136
• 负责人: Kayo Fujimoto
• 金额: $ 3.81万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9480136
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adherence; Affordable Care Act; Alcohol or Other Drugs use; Back; Behavior; Behavioral; Caring; Chicago; Cities; Clinical Trials; Communities; Complex; County; Couples; Criminal Justice; Data; Data Sources; Disease; Drug usage; Effectiveness; Event; Friends; Future; Geography; HIV; HIV Infections; Health; Household; Imprisonment; Incidence; Individual; Institution; Integration Host Factors; Intervention; Intervention Studies; Jail; Laboratories; Lead; Life; Link; Los Angeles; Marijuana; Modeling; Pathway Analysis; Policies; Population; Populations at Risk; Prevention; Preventive; Preventive Intervention; Probability; Publishing; Randomized Controlled Trials; Research; Research Personnel; Risk; Risk Behaviors; Role; Services; Sexually Transmitted Diseases; Shock; Social Environment; Social Network; Specific qualifier value; Structure; Substance abuse problem; Supervision; Systems Analysis; Target Populations; Time; United States; Validation; Viral; Work; base; black men who have sex with men; clinical care; cooking; cost; data modeling; disparity reduction; dynamic system; flexibility; infectious disease model; intervention effect; mathematical model; men; network models; pre-exposure prophylaxis; public health relevance; scale up; service utilization; simulation; social; time use; transmission process; treatment planning; young men who have sex with men

 DESCRIPTION (provided by applicant): Large disparities in HIV rates in black men who have sex with men (BMSM) are not explained by higher engagement in risky behaviors and are particularly high among younger MSM. Despite the efficacy of several prevention interventions, reducing these disparities requires approaches that maximally engage these men's social and sexual networks. Because of frequently transient life circumstances, disruption of social and sexual networks and HIV transmission overlap with other groups, criminal justice involved (CJI) BMSM who use substances represent an important target for intervention. Although effective behavioral and structural interventions exist that target CJI populations, their successful implementation for CJI BMSM networks and communities has not been demonstrated. Furthermore, research to determine intervention impact at these larger social units is costly and does not readily lend itself to the randomized control trial approach. This proposal aims to utiliz a systems dynamic approach using an agent-based model (ABM) to estimate the effectiveness of HIV prevention and substance-abuse interventions for CJI substance-using BMSM. Our project brings together investigators with a proven track record in the study of BMSM, criminal justice settings, substance-abuse intervention, social network analysis, ABMs and HIV clinical care provision. We will adapt a previously developed core open access ABM platform (using Repast Simphony) that includes baseline national data on people and households by geography, as well as the dynamic features of the target population such as incarceration, health center, and activity (time-use) data. We will scale the ABM to three counties: Harris TX, Los Angeles CA, and Cook IL where our team has collected data for model parameterization. Our approach will assess the interplay between social and behavioral variables and viral and host factors in a matter that will be adaptive to temporal, network and setting-specific changes. Our aims are to: 1) Build upon our flexible ABM by incorporating HIV transmission and suppression probabilities at the individual level, including host/viral factors and biologic/behavioral data from HIV prevention and substance-abuse intervention studies; 2) Parameterize this ABM with multiple network data sources available to investigators in each city on specific transition periods of BMSM from the community, to jail, and back to the community/ supervision; such "shocks" lead to social and sexual network formation and disruption. We will supplement these data with newly collected data (n=50/city) specifically on network shocks and HIV prevention and treatment utilization during these critical transition periods; 3) Simulate HIV prevention interventions within criminal justice contexts using the model parameterized in Aim 2. Because our open access Repast Simphony ABM platform is widely used, we will make model parameters, specifications and variables publically available. This will allow for external validation of our findings and for additional use of the core model by others for context and community-specific integrated HIV prevention and treatment planning in at risk populations.

 描述（由适用提供）：与男性发生性关系（BMSM）的黑人艾滋病毒率的较大差异并未通过更高的危险行为参与来解释，并且在年轻的MSM中尤其很高。尽管有几种预防干预措施的效率，但减少这些差异需要最大程度地吸引这些人的社会和性网络的方法。由于经常暂时的生活环境，社会和性网络的破坏以及艾滋病毒的传播与其他团体重叠，涉及的刑事司法（CJI）BMSM使用物质是干预的重要目标。尽管存在针对CJI人群的有效的行为和结构干预措施，但尚未证明其成功实施CJI BMSM网络和社区。此外，确定这些较大社会单位的干预影响的研究成本很高，并且不容易使自己适合随机控制试验方法。该提案旨在使用基于代理的模型（ABM）使用系统动态方法来估算使用CJI物质 - 使用BMSM的HIV预防和滥用物质干预措施的有效性。我们的项目将调查人员汇集在BMSM，刑事司法环境，药物滥用干预，社交网络分析，ABMS和HIV临床护理方面的研究中具有良好的记录。我们将适应先前开发的核心开放访问ABM平台（使用Repast Simphony），其中包括通过地理位置的基线国家数据，以及目标人群的动态特征，例如进化，健康中心和活动（时间使用）数据。我们将将ABM扩展到三个计数：Harris TX，Los Angeles CA和Cook IL，我们的团队已收集数据以进行模型参数化。我们的方法将评估社会和行为变量与病毒和宿主因素之间的相互作用，这些问题将适应临时，网络和特定于设置的变化。我们的目的是：1）通过在个体层面转换HIV传播和抑制可能性，包括宿主/病毒因素以及来自HIV预防的宿主/病毒/行为数据，并基于我们的灵活ABM。 2）在每个城市的调查人员可以在BMSM的特定过渡期间，从社区到监狱再到社区/监督，每个城市的调查员都可以使用多个网络数据源来参数化ABM；这种“震惊”导致社会和性网络形成和破坏。我们将在这些关键过渡期内专门针对网络冲击和艾滋病毒的预防和治疗利用来补充这些数据（n = 50/City）； 3）使用AIM 2参数化的模型在刑事司法环境中模拟艾滋病毒预防干预措施。由于我们的开放访问权益访问simphony abm平台被广泛使用，因此我们将公开使用模型参数，规格和变量。这将允许对我们发现的外部验证，并允许其他人在风险种群中对他人进行核心模型的额外使用，以进行环境和社区特定的综合艾滋病毒预防和治疗计划。