Multimodal Imaging of Recovery from Cannabis Dependence
大麻依赖恢复的多模态成像
基本信息
- 批准号:9349476
- 负责人:
- 金额:$ 74.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-15 至 2020-07-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAffectAgeAgonistAnimalsApplications GrantsAreaAuditoryAwarenessBindingBiological Neural NetworksBrainBrain imagingCNR1 geneCannabinoidsCannabisChronicConsciousConsumptionDataDown-RegulationElectroencephalographyElectrophysiology (science)EquilibriumEventExhibitsExposure toFemaleFrequenciesFundingG-BandingGenerationsHourHumanImageImpairmentIndividualInpatientsInterneuronsLegalLigandsLightLinkMaintenanceMarijuana DependenceMarijuana SmokingMeasuresMediatingMedicalMedical MarijuanaMethodologyMethodsMonitorMultimodal ImagingNational Institute of Drug AbuseNeurobiologyNeurocognitiveNeurophysiology - biologic functionOutcomePerformancePositron-Emission TomographyPreparationReceptor ActivationRecoveryResearchResolutionRoleSamplingSensorySensory ReceptorsShort-Term MemorySliceSourceSpicesSystemTetrahydrocannabinolTimeVerbal LearningWithdrawalWorkbasecannabinoid receptorcannabis withdrawalcognitive functioncognitive taskdensitydesignexogenous cannabinoidillicit drug useimaging modalityin vivoindexinginformation processinginterestmarijuana useneural information processingneuroimagingneurotransmissionpostsynapticreceptorreceptor downregulationreceptor functionrelating to nervous systemsynthetic cannabinoidtomographytooltransmission process
项目摘要
PROJECT SUMMARY AND ABSTRACT
Background: Cannabis is the most commonly used illicit drug worldwide. The potency of cannabis has
increased and so has the use of highly potent synthetic cannabinoids (`Spice'). Furthermore, the “medical” and
recreational use of cannabis is increasingly being legalized across the U.S. Therefore, it is important to
understand the consequences of chronic cannabinoid exposure on the brain, including the consequences of
these changes on neural function, and importantly if/how these evolve when cannabis use stops. Cannabinoid
receptor (CB1R) availability can be measured in vivo using Positron Emission Tomography (PET). Neural
oscillations, an index of information processing, are sensitive to the effects of CB1R activation and can be
measured using electroencephalography (EEG).
Hypotheses: Cannabis dependent subjects (CDs) will show lower CB1R availability at baseline relative to
controls. CB1R availability will begin to normalize after 48 hours of abstinence (but not to HC levels) and will
return to control levels after 4 weeks of abstinence. CDs will exhibit decreased θ- and γ-band neural
oscillations compared to HCs at baseline, which will be most disrupted after 48 hours of abstinence and will
return to control levels after 4 weeks of abstinence. Across the 3 time points, measures of θ- and γ-band
oscillations will correlate with CB1R availability. Finally, CB1R availability, θ- and γ-band power, and coherence
will correlate with performance on the cognitive tasks.
Methods: The proposed study will utilize 1) CB1R PET ligand [11C]OMAR and High Resolution Research
Tomography (HRRT) and 2) EEG to evaluate the temporal course of CB1R availability and neural oscillations,
respectively, in cannabis-dependent individuals (n=25) at baseline (smoking cannabis as usual), following brief
(48 hour) monitored inpatient abstinence (when cannabis withdrawal is most likely to occur), and after
prolonged (4 weeks) monitored abstinence. Neurocognitive outcomes (e.g., verbal learning) which are known
to be impaired by chronic cannabis exposure will also be assessed in order to relate the receptor and
electrophysiological findings to domains germane to “real world” functioning. A sample of healthy control
individuals (n=12) will also be assessed at the same time points. This design will allow both within-subject and
between-subject analyses across three time points.Taken together, it is hoped that data from this study will
elucidate the neurobiological consequences of chronic cannabis consumption and its effect on CB1Rs, and will
shed new light on the status and function of CB1Rs during active cannabis use, and withdrawal.
项目摘要和摘要
背景:大麻是全世界最常用的非法药物。大麻的效力有
使用高效合成大麻素(“香料”)的情况也有所增加。此外,“医疗”和
娱乐性使用大麻在美国越来越合法化。因此,重要的是
了解长期接触大麻素对大脑的影响,包括
这些对神经功能的变化,以及重要的是当大麻停止使用时这些变化是否/如何演变。大麻素
受体(CB1R)的利用度可以使用正电子发射断层扫描(PET)在体内测量。神经
振荡是信息处理的一个指标,对CB1R激活的影响很敏感,可以
使用脑电图仪(EEG)测量。
假设:大麻依赖受试者(CDs)在基线时CB1R的可用性将低于
控制。CB1R的可用性将在戒断48小时后开始正常化(但不会达到HC水平),并将
禁食4周后,恢复到对照水平。CDS将显示θ和γ频段神经细胞减少
与基线时的HCS相比,在戒酒48小时后最容易受到干扰,并将
禁食4周后,恢复到对照水平。跨越3个时间点,衡量θ和γ频段
振荡将与CB1R的可用性相关。最后,CB1R可用性、θ和γ频段功率以及一致性
将与认知任务的表现相关。
方法:建议的研究将利用1)CB1R PET配体[11C]Omar和高分辨率研究
断层扫描(HRRT)和2)EEG来评估CB1R可用性和神经振荡的时间过程,
分别在基线(像往常一样吸食大麻)时对大麻依赖者(n=25),简要如下
(48小时)监测住院患者的戒断情况(最有可能戒除大麻的时候),以及之后
持续(4周)监测戒酒。已知的神经认知结果(例如,语言学习)
也将对长期接触大麻而受损的人进行评估,以将受体和
电生理学发现与“真实世界”功能密切相关的领域。一个健康对照的样本
个人(n=12)也将在相同的时间点接受评估。这种设计将允许受试者内和
跨三个时间点的受试者间分析。总的来说,希望这项研究的数据将
阐明长期吸食大麻的神经生物学后果及其对CB1Rs的影响,并将
进一步阐明了CB1Rs在大麻的积极使用和戒断过程中的地位和作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MOHINI RANGANATHAN其他文献
MOHINI RANGANATHAN的其他文献
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{{ truncateString('MOHINI RANGANATHAN', 18)}}的其他基金
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
大麻二酚对小胶质细胞激活和中枢疼痛敏化的影响
- 批准号:
10847024 - 财政年份:2019
- 资助金额:
$ 74.08万 - 项目类别:
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
大麻二酚对小胶质细胞激活和中枢疼痛敏化的影响
- 批准号:
9895343 - 财政年份:2019
- 资助金额:
$ 74.08万 - 项目类别:
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
大麻二酚对小胶质细胞激活和中枢疼痛敏化的影响
- 批准号:
10025663 - 财政年份:2019
- 资助金额:
$ 74.08万 - 项目类别:
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
大麻二酚对小胶质细胞激活和中枢疼痛敏化的影响
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10074663 - 财政年份:2019
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