Training of Junior Faculty for Careers in Omics of Lung Diseases

肺部疾病组学初级教师职业培训

基本信息

批准号：
9283609
负责人：
ROBERT L. GROSSMAN
金额：
$ 33.89万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The Univ of Chicago K12 Career Development Program in Omics of Lung Diseases will establish a new pathway for the further training of physician and non-physician junior faculty scientists in the integration and analysis of large data sets to gain new insights into the pathogenetic mechanisms underlying lung diseases and translate these insights into tools for disease diagnosis, treatment, and monitoring. Only junior faculty will be enrolled as Scholars in this 2-year training program, which requires at least 80% commitment. Each will engage in an individualized curriculum of classroom courses and hands-on training, and will apply these skills in a multidimensional, highly-mentored research learning experience. The pro- gram focuses on three respiratory health problems - asthma, childhood sleep disordered breathing, and pulmonary fibrosis - because of their enormous health and economic importance's and the deep and broad expertise at UC in these areas; and because each is paradigmatic of common but complex disease syndromes in which many different combinations of genetic, epigenetic, and environmental factors conspire to generate a series of closely similar clinical phenotypes that are collectively named as single entities. Recognizing the commonalities of seemingly disparate diseases, we include a fourth training pathway that emphasizes a systems biological approach that spans all three disease groups. An explicit goal of this program that its training opportunities and benefits will extend beyond the relatively few Scholars whose stipends it will provide, into the larger respiratory biology community at our University and in Chicago, and to young scientists pursuing omics/informatics approaches to common, complex diseases whose principal target organs are other than the lung (e.g., diabetes, hypertension, etc). We expect that at least 7 Scholars will be trained in this program, which leverages extensive data collections and other research and training resources already available at the University, and brings faculty into the study of respiratory disease who had not previously worked in this area.

描述（由申请人提供）：芝加哥K12职业发展肺部疾病的职业发展计划将建立新的途径，以进一步培训医师和非医师的初级教师科学家，以整合和分析大数据的整合和分析设定以获取对肺部疾病潜在的致病机制的新见解，并将这些见解转化为用于疾病诊断，治疗和监测的工具。只有初级教职员工才能作为学者参加这项为期两年的培训计划，该计划需要至少80％的承诺。每个人都将参加课堂课程和动手培训的个性化课程，并将这些技能应用于多维，备受瞩目的研究学习经验。该研究的重点是三个呼吸健康问题 - 哮喘，儿童睡眠失调和肺纤维化 - 由于其巨大的健康和经济重要性以及在这些领域的UC的深厚和广泛的专业知识；而且因为每个人都是常见但复杂疾病综合征的范式，其中许多不同的遗传，表观遗传和环境因素组合共同生成一系列非常相似的临床表型，这些表型统称为单一实体。认识到看似不同的疾病的共同点，我们包括第四个训练途径，该训练途径强调了一种跨越所有三个疾病组的系统生物学方法。该计划的明确目标是，其培训机会和福利将超出相对较少的学者，其津贴将提供的津贴将提供给我们大学和芝加哥的更大的呼吸生物学社区，以及年轻的科学家，追求对常见的，复杂的疾病，其主要靶心是其主要靶心的杂音/信息学方法，其主要靶心是肺部以外的其他疾病（例如，Hypersemente，Hypersemention，Hypersemention，Hypersemention，Hypertementions，hypertementions，hypertementions）。我们预计，该计划将至少对7名学者进行培训，该计划利用该计划的大量数据收集以及其他研究和培训资源已经在大学提供，并将教师带入以前从未在该领域工作的呼吸道疾病的研究。