Training of Junior Faculty for Careers in Omics of Lung Diseases

描述(由申请者提供)：芝加哥大学肺部疾病OMICS专业的K12职业发展计划将建立一条新的途径，进一步培训内科和非内科初级学院的科学家整合和分析大数据 旨在对肺部疾病的发病机制获得新的见解，并将这些见解转化为疾病诊断、治疗和监测的工具。在这个为期两年的培训计划中，只有初级教师将被录取为奖学金获得者，这需要至少80%的承诺。每个人都将参与课堂课程和实践培训的个性化课程，并将这些技能应用于多维的、高度指导的研究性学习体验。该项目重点关注三个呼吸道健康问题-哮喘、儿童睡眠障碍呼吸和肺纤维化-因为它们具有巨大的健康和经济重要性，以及加州大学在这些领域的深厚和广泛的专业知识；而且因为每个问题都是常见但复杂的疾病综合征的典范，在这些症状中，遗传、表观遗传和环境因素的许多不同组合共同产生了一系列非常相似的临床表型，统称为单一实体。认识到 对于看似不同的疾病的共性，我们包括第四条培训途径，强调跨越所有三种疾病组的系统生物学方法。该计划的一个明确目标是，其培训机会和好处将超越其将提供津贴的相对较少的学者，扩展到我们大学和芝加哥更大的呼吸系统生物学社区，以及寻求组学/信息学方法来研究主要目标器官不是肺部的常见复杂疾病(例如糖尿病、高血压等)的年轻科学家。我们预计至少有7名学者将接受这一计划的培训，该计划利用了广泛的数据收集和大学现有的其他研究和培训资源，并将以前从未在这一领域工作过的教员带入呼吸系统疾病的研究。

DESCRIPTION (provided by applicant): The Univ of Chicago K12 Career Development Program in Omics of Lung Diseases will establish a new pathway for the further training of physician and non-physician junior faculty scientists in the integration and analysis of large data sets to gain new insights into the pathogenetic mechanisms underlying lung diseases and translate these insights into tools for disease diagnosis, treatment, and monitoring. Only junior faculty will be enrolled as Scholars in this 2-year training program, which requires at least 80% commitment. Each will engage in an individualized curriculum of classroom courses and hands-on training, and will apply these skills in a multidimensional, highly-mentored research learning experience. The pro- gram focuses on three respiratory health problems - asthma, childhood sleep disordered breathing, and pulmonary fibrosis - because of their enormous health and economic importance's and the deep and broad expertise at UC in these areas; and because each is paradigmatic of common but complex disease syndromes in which many different combinations of genetic, epigenetic, and environmental factors conspire to generate a series of closely similar clinical phenotypes that are collectively named as single entities. Recognizing the commonalities of seemingly disparate diseases, we include a fourth training pathway that emphasizes a systems biological approach that spans all three disease groups. An explicit goal of this program that its training opportunities and benefits will extend beyond the relatively few Scholars whose stipends it will provide, into the larger respiratory biology community at our University and in Chicago, and to young scientists pursuing omics/informatics approaches to common, complex diseases whose principal target organs are other than the lung (e.g., diabetes, hypertension, etc). We expect that at least 7 Scholars will be trained in this program, which leverages extensive data collections and other research and training resources already available at the University, and brings faculty into the study of respiratory disease who had not previously worked in this area.