Training of Junior Faculty for Careers in Omics of Lung Diseases

描述（由申请人提供）：芝加哥大学K12职业发展计划在肺部疾病组学将建立一个新的途径，进一步培训医生和非医生初级教师科学家在大数据的整合和分析 旨在获得对肺部疾病发病机制的新见解，并将这些见解转化为疾病诊断，治疗和监测的工具。只有初级教师将被录取为学者在这个为期2年的培训计划，这需要至少80%的承诺。每个人都将参与个性化的课堂课程和实践培训课程，并将这些技能应用于多维度，高度指导的研究学习体验。该计划侧重于三个呼吸系统健康问题-哮喘，儿童睡眠呼吸障碍和肺纤维化-因为它们具有巨大的健康和经济重要性以及UC在这些领域的深厚和广泛的专业知识;因为每一种都是常见但复杂的疾病综合征的典范，其中遗传，表观遗传，和环境因素共同产生了一系列非常相似的临床表型，这些表型被统称为单一实体。认识到 为了解决看似完全不同的疾病的共同点，我们包括第四个培训途径，强调跨越所有三个疾病组的系统生物学方法。该计划的一个明确目标是，其培训机会和益处将超出其奖学金将提供的相对较少的学者，进入我们大学和芝加哥更大的呼吸生物学社区，以及追求组学/信息学方法的年轻科学家，这些方法的主要靶器官是肺部以外的常见复杂疾病（例如，糖尿病、高血压等）。我们预计，至少有7名学者将在该计划中接受培训，该计划利用了大学现有的广泛数据收集和其他研究和培训资源，并将以前没有在该领域工作过的教师带入呼吸系统疾病的研究。

DESCRIPTION (provided by applicant): The Univ of Chicago K12 Career Development Program in Omics of Lung Diseases will establish a new pathway for the further training of physician and non-physician junior faculty scientists in the integration and analysis of large data sets to gain new insights into the pathogenetic mechanisms underlying lung diseases and translate these insights into tools for disease diagnosis, treatment, and monitoring. Only junior faculty will be enrolled as Scholars in this 2-year training program, which requires at least 80% commitment. Each will engage in an individualized curriculum of classroom courses and hands-on training, and will apply these skills in a multidimensional, highly-mentored research learning experience. The pro- gram focuses on three respiratory health problems - asthma, childhood sleep disordered breathing, and pulmonary fibrosis - because of their enormous health and economic importance's and the deep and broad expertise at UC in these areas; and because each is paradigmatic of common but complex disease syndromes in which many different combinations of genetic, epigenetic, and environmental factors conspire to generate a series of closely similar clinical phenotypes that are collectively named as single entities. Recognizing the commonalities of seemingly disparate diseases, we include a fourth training pathway that emphasizes a systems biological approach that spans all three disease groups. An explicit goal of this program that its training opportunities and benefits will extend beyond the relatively few Scholars whose stipends it will provide, into the larger respiratory biology community at our University and in Chicago, and to young scientists pursuing omics/informatics approaches to common, complex diseases whose principal target organs are other than the lung (e.g., diabetes, hypertension, etc). We expect that at least 7 Scholars will be trained in this program, which leverages extensive data collections and other research and training resources already available at the University, and brings faculty into the study of respiratory disease who had not previously worked in this area.