Training of Junior Faculty for Careers in Omics of Lung Diseases

肺部疾病组学初级教师职业培训

• 批准号: 8575164
• 负责人: ROBERT L. GROSSMAN
• 金额: $ 12.42万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8575164
• 关键词: Area; Biology; Chicago; Childhood Asthma; Communities; Complex; Data Collection; Data Set; Diabetes Mellitus; Disease; Educational Curriculum; Enrollment; Environmental Risk Factor; Epigenetic Process; Faculty; Genetic; Goals; Health; Hypertension; Informatics; Learning; Lung; Lung diseases; Mentors; Monitor; Names; Organ; Pathway interactions; Physicians; Pulmonary Fibrosis; Research; Research Training; Resources; SECTM1 gene; Scientist; Series; Sleep Apnea Syndromes; Syndrome; Training; Training Programs; Translating; Universities; Work; biological systems; career; career development; clinical phenotype; disease diagnosis; experience; health economics; insight; programs; respiratory; skills; tool

DESCRIPTION (provided by applicant): The Univ of Chicago K12 Career Development Program in Omics of Lung Diseases will establish a new pathway for the further training of physician and non-physician junior faculty scientists in the integration and analysis of large data sets to gain new insights into the pathogenetic mechanisms underlying lung diseases and translate these insights into tools for disease diagnosis, treatment, and monitoring. Only junior faculty will be enrolled as Scholars in this 2-year training program, which requires at least 80% commitment. Each will engage in an individualized curriculum of classroom courses and hands-on training, and will apply these skills in a multidimensional, highly-mentored research learning experience. The pro- gram focuses on three respiratory health problems - asthma, childhood sleep disordered breathing, and pulmonary fibrosis - because of their enormous health and economic importance's and the deep and broad expertise at UC in these areas; and because each is paradigmatic of common but complex disease syndromes in which many different combinations of genetic, epigenetic, and environmental factors conspire to generate a series of closely similar clinical phenotypes that are collectively named as single entities. Recognizing the commonalities of seemingly disparate diseases, we include a fourth training pathway that emphasizes a systems biological approach that spans all three disease groups. An explicit goal of this program that its training opportunities and benefits will extend beyond the relatively few Scholars whose stipends it will provide, into the larger respiratory biology community at our University and in Chicago, and to young scientists pursuing omics/informatics approaches to common, complex diseases whose principal target organs are other than the lung (e.g., diabetes, hypertension, etc). We expect that at least 7 Scholars will be trained in this program, which leverages extensive data collections and other research and training resources already available at the University, and brings faculty into the study of respiratory disease who had not previously worked in this area.

描述（由申请人提供）：芝加哥大学 K12 肺部疾病组学职业发展计划将为医师和非医师初级教师科学家在大数据整合和分析方面的进一步培训建立一条新途径 旨在获得对肺部疾病发病机制的新见解，并将这些见解转化为疾病诊断、治疗和监测的工具。只有初级教师才能作为学者参加这个为期 2 年的培训计划，该计划需要至少 80% 的承诺。每个人都将参加个性化的课堂课程和实践培训课程，并将这些技能应用于多维、高度指导的研究学习体验中。该计划重点关注三种呼吸系统健康问题——哮喘、儿童睡眠呼吸障碍和肺纤维化——因为它们对健康和经济具有巨大的重要性，并且加州大学在这些领域拥有深厚而广泛的专业知识；因为每一种都是常见但复杂的疾病综合征的典范，其中遗传、表观遗传和环境因素的许多不同组合共同产生了一系列密切相似的临床表型，这些表型统称为单个实体。认识到 鉴于看似不同疾病的共性，我们提供了第四种培训途径，强调涵盖所有三个疾病组的系统生物学方法。该计划的明确目标是，其培训机会和好处将超越其提供的津贴的相对少数学者，进入我们大学和芝加哥更大的呼吸生物学界，以及对主要靶器官不是肺的常见复杂疾病（例如糖尿病、高血压等）寻求组学/信息学方法的年轻科学家。我们预计至少有 7 名学者将在该计划中接受培训，该计划利用大学现有的广泛数据收集和其他研究和培训资源，并将以前未在该领域工作过的教师带入呼吸系统疾病的研究。