CSHL Cancer Center Support Grant

CSHL癌症中心-总体项目摘要/摘要 冷泉港实验室(CSHL)癌症中心是一家主要的癌症研究中心，使用 创新和协作的方法，以应对癌症面临的一些最紧迫的挑战 今天的生物学家和癌症患者。特别是，CSHL癌症中心的研究主要集中在两个主要方面 问题：改善癌症诊断和提高治疗效果。 CSHL癌症中心的研究人员正在使用尖端的遗传和基因组方法来 癌症的分子特征。这项研究的目标是开发新的诊断工具和 还要确定癌症亚型，以便临床医生能够选择最有效的治疗方法。 CSHL癌症中心的研究人员处于开发和应用这些基因组方法的前沿； 像单细胞测序这样的发现具有革命性的诊断能力，并且已经 在临床上显示出巨大的潜力。 CSHL癌症中心正在建立其在基础发现科学方面的杰出基础，以识别和 为多种肿瘤类型开发新的治疗靶点。十多年前，癌症中心 通过创建一条“癌症发现管道”，正式确立了这一战略。该计划整合了基础癌症 生物学、人类癌症遗传学、高通量筛查技术和创新的动物模型 努力改进现有的癌症治疗方法。这条管道非常成功。癌 中心的研究人员发现了新的癌症基因，确定了潜在的治疗靶点，并探索了 新的耐药机制。随着这项基础研究的继续，癌症中心的目标是扩大 更进一步进入翻译研究的管道。在接下来的五年里，作为癌症治疗计划的一部分 在这一倡议下，癌症中心将把其基础研究发现带到临床前和临床环境中。 来自国家癌症研究所的资金为CSHL癌症中心提供了组织和 需要财政支持才能对癌症诊断和治疗产生重大影响。三项研究 计划(基因调控和细胞增殖；信号转导；癌症遗传学)提供机会 让成员走到一起，最大限度地提高协作和沟通。九大共享资源 提供获取技术、服务和专业知识的途径，以提高工作效率并促进多学科合作 互动。基本发展基金使该中心保持在癌症研究的前沿。 CSHL癌症中心的这些要素共同创造了一个支持以下水平的环境 科学发现需要在改进癌症诊断和治疗方面取得真正进展。

CSHL Cancer Center – Overall Project Summary/Abstract The Cold Spring Harbor Laboratory (CSHL) Cancer Center is a premier cancer research center that uses innovative and collaborative approaches to address some of the most pressing challenges facing cancer biologists and cancer patients today. In particular, research in CSHL Cancer Center is focused on two primary problems: improving cancer diagnostics and increasing therapeutic effectiveness. Researchers in the CSHL Cancer Center are employing cutting edge genetic and genomic approaches to molecularly characterize cancer. The goals of this research are to both develop new diagnostic tools and to also define cancer subtypes so that clinicians will be able to select the most effective therapeutic approaches. CSHL Cancer Center researchers are at the forefront of developing and applying these genomic approaches; discoveries like single cell sequencing have the power to revolutionize diagnostics and are already demonstrating tremendous potential in the clinic. The CSHL Cancer Center is building upon its outstanding foundation in basic discovery science to identify and develop new therapeutic targets for multiple tumor types. More than ten years ago, the Cancer Center formalized this strategy with the creation of a “cancer discovery pipeline.” The plan integrated basic cancer biology, human cancer genetics, high-throughput screening technology, and innovative animal models in an effort to improve existing treatments for cancer. This pipeline has been tremendously successful. Cancer Center researchers have discovered new cancer genes, identified potential therapeutic targets, and explored new drug resistance mechanisms. As this basic research continues, the Cancer Center is aiming to extend the pipeline even further into translational research. Over the next five years, as part of a Cancer Therapeutics Initiative, the Cancer Center will bring its basic research discoveries to preclinical and clinical settings. Funding from the National Cancer Institute provides the CSHL Cancer Center with the organizational and financial support needed to make a significant impact on cancer diagnosis and treatment. The three research programs (Gene Regulation & Cell Proliferation; Signal Transduction; Cancer Genetics) provide opportunities for members to come together, maximizing collaboration and communication. The nine Shared Resources provide access to technologies, services, and expertise to enhance productivity and promote multidisciplinary interactions. Essential Developmental Funds enable the Center to remain at the forefront of cancer research. Together, these elements of the CSHL Cancer Center create an environment that supports the level of scientific discovery required to make real progress in improving cancer diagnosis and treatment.