CSHL Cancer Center Support Grant

总体-摘要 冷泉港实验室（CSHL）癌症中心是一个卓越的基础癌症研究机构。 50多年前，战略重点的努力调查了人类癌症的遗传学，奠定了 为今天的多项突破奠定了基础。因此，CSHL癌症中心的研究人员 关于肿瘤如何发生和发展的发现，他们已经产生了新的工具，方法， 癌症模型在世界各地使用。 在过去的五年里，CSHL癌症中心的领导层顺利过渡，大卫Tuveson 担任中心主任。Tuveson大幅扩大了癌症中心的领导团队， 重组了计划和共享资源，并增加了新的研究基础设施，以支持新的 倡议，并保持中心的高度协作和综合研究。CSHL癌症中心 现有正式成员43人，分为三个研究项目：癌症遗传学和基因组学; 基因调控和遗传;癌症中的细胞通讯。这些项目中的研究 由10个共享资源提供支持，这些资源提供尖端技术和专业知识。 这种转变推动了癌症中心的研究卓越。大体上，癌症中心专注于 三大主题：确定癌症发展的基本分子机制， 确定驱动肿瘤发生的肿瘤和基质细胞异质性的特征; 并开发新的实验和计算技术，以帮助癌症诊断和治疗。 在此资助周期内，中心成员发表了408篇癌症相关研究论文，其中41%发表在期刊上。 影响因子大于10。癌症中心成员因其重大贡献而受到表彰 在本资助期内，科学界获得了43个极具竞争力的国家和国际奖项。癌症 中心继续保持高度协作，27%的出版物代表了 至少有两名中心成员。最后，为了支持这些努力，成员们已经获得了1180万美元， 与癌症相关的同行评审资金。 在下一个资助期内，癌症中心将继续利用 基础研究同时，癌症中心致力于增加与癌症患者的联系， 患者衍生模型，以促进人类生物学和临床翻译的扩展。癌症基金 中心支持补助金将支持癌症中心的领导，行政，教育和培训， 促进创新科学的发展基金，以及提供必要的 技术来推进我们的癌症研究。

OVERALL – ABSTRACT The Cold Spring Harbor Laboratory (CSHL) Cancer Center is a preeminent institute for basic cancer research. More than 50 years ago, strategically focused efforts investigated the genetics of human cancer, laying the foundation for multiple breakthroughs today. As a result, researchers in the CSHL Cancer Center have made discoveries about how tumors initiate and progress, and they have produced novel tools, approaches, and cancer models that are used around the world. Over the last five years, the leadership of the CSHL Cancer Center transitioned smoothly, with David Tuveson assuming the role of Center Director. Tuveson substantially expanded the Cancer Center leadership team, reorganized the Programs and Shared Resources, and added new research infrastructure to support new initiatives and maintain the highly collaborative and integrated research in the Center. The CSHL Cancer Center now has 43 full members, who are divided into three research programs: Cancer Genetics and Genomics; Gene Regulation and Inheritance; and Cellular Communication in Cancer. The research in these Programs is supported by 10 Shared Resources, which provide access to cutting-edge technologies and expertise. This transition has propelled the Cancer Center’s research excellence. Broadly, the Cancer Center focuses on three major themes: defining the basic molecular mechanisms underpinning cancer development and progression; determining the features of neoplastic and stromal cellular heterogeneity that drive tumorigenesis; and developing novel experimental and computational technologies to assist cancer diagnosis and therapy. Center members published 408 cancer-relevant research papers during this funding cycle, with 41% in journals with an impact factor greater than 10. Cancer Center members were recognized for their significant contributions to science with 43 highly competitive national and international awards during this funding period. The Cancer Center continues to be highly collaborative, with 27% of publications representing a collaboration between at least two Center members. And finally, to support these efforts, members have obtained $11.8 million dollars in cancer-relevant, peer-reviewed funding. In the next funding period, the Cancer Center will continue to make foundational discoveries about cancer using basic research. At the same time, the Cancer Center is committed to increasing links to cancer patients and patient-derived models to facilitate an extension to human biology and clinical translation. Funds from the Cancer Center Support Grant will support the Cancer Center Leadership, Administration, Education and Training, the Developmental Funds that enhance innovative science, and the Shared Resources that provide essential technologies to advance our cancer research.