Admin Core

该计划项目的长期目标是开发一个发现自然资源的平台 生产抗菌剂，并为药物开发提供线索。该平台将解决 目前抗菌剂发现的瓶颈--缺乏良好的先导化合物。三个PI来自 不同的机构都参与了这个雄心勃勃的项目。相关项目：i)缺乏文化修养 细菌用于发现新的抗菌剂；II)转录组对抗生素的去复制 分析；iii)抗菌剂的评价和开发。我们的根本创新之处 拟议的项目是使用转录图谱快速去复制来识别有吸引力的 未经培养的细菌所藏匿的化合物。行政核心的目标是 促进和促进项目目标的实现。 计划主任将负责整个计划并监督 行政核心。方案主任(PD/PI)的主要优先事项是促进 三个研究项目的进展和成功，从而使该方案取得成功 项目。他的努力将得到一个计划咨询委员会和 行政核心经理。行政核心经理将协调日常工作 三个相互关联的项目的绩效指标和人员之间的互动。经理将 与PD/PI、组成项目PI、执行委员会和计划一起工作 咨询委员会协助进行科学、行政和财政监督。 经理将促进整个项目的沟通，并安排小组 为项目成员和方案会议举行的会议和电话会议 咨询委员会。经理将处理该计划的管理细节， 与NIAID的互动，并协助编写提交NIAID的定期报告。这个 经理将定期向PD/PI提供每个项目的财务状况报告，并 组织项目负责人年度会议，对项目进行评审和调整 预算。核心经理将与IT专家一起创建和维护计划 网站。该网站将使项目参与者能够收集、存储和分析来自 该中心的所有项目；该网站还将用于传播关于 程序。

The long-term goal of the Program Project is to develop a platform for the discovery of natural product antimicrobials, and to provide leads for drug development. This platform will resolve the current bottleneck in antimicrobial discovery – lack of good lead compounds. Three PIs from different Institutions are involved in this ambitious project. The related projects are I) Uncultured bacteria for the discovery of novel antimicrobials; II) Antibiotic dereplication by transcriptome analysis; III) Antimicrobial evaluation and development. The essential innovation of our proposed project is to use rapid dereplication by transcription profiling to identify attractive compounds harbored by uncultured bacteria. The objective of the Administrative core is To promote and facilitate the achievement of the goals of the Program Project. The Program Director will be responsible for the overall program and for overseeing the Administrative core. The major priority of the Program Director (PD/PI) is to promote the progress and success of the three research projects and thereby the success of the Program Project. His efforts will be augmented by a Program Advisory Committee and by the Administrative Core Manager. The Administrative Core Manager will coordinate the day-to-day interactions among the PIs and personnel of the three interrelated projects. The Manager will work with the PD/PI, component project PIs and Executive Committee and the Program Advisory Committee to assist with the scientific, administrative and fiscal oversight. The Manager will facilitate communications throughout the Program, and arrange group meetings and teleconferences for members of the project and for meetings of the Program Advisory Committee. The Manager will handle the administrative details of the Program and, interactions with the NIAID and assist in the preparation of regular reports to the NIAID. The Manager will provide the PD/PI with regular reports on the financial status of each project and organize annual meetings of the Project Leaders to review and make adjustments to project budgets. The Core Manager will work with an IT expert to create and maintain a Program website. The website will enable project participants to collect, store and analyze their data from all of the projects of the center; the website will also serve to disseminate information on the Program.