Community-Based Evaluation of Sudden Cardiac Death in Hispanics/Latinos

项目说明 心脏骤停(SCA)是一种突然的灾难性脉搏丧失，每年在美国影响350,000人， A&GT；90%的死亡率。因此，改进初级预防是一项主要优先事项。SCA负担受以下因素影响 种族，社会经济地位，以及潜在的种族。拉美裔/拉丁裔(HL)人数最多，速度最快 越来越多的美国少数民族，但在这个亚群中还没有关于SCA的前瞻性研究。我们表演了一年(2015) 加利福尼亚州文图拉县所有居民SCA的前瞻性试点研究(预测#年猝死 多民族聚居区，由派创建)，人口分布42.3%HL(&gt；% 墨西哥血统)和48.7%的非西班牙裔白人(Nhw)。在临床特征上有显著差异。 HL(n=71)与NHW(n=204)。我们的试点数据还表明了HL中SCA的其他独特方面，特别是 与女性有关，以及肥胖的作用。这项提案的总体目标是确定特定种族 改进SCA预测和预防的目标。拉美裔社区健康研究/拉丁裔研究 (HCHS/SOL)是由美国国立卫生研究院资助的一项多中心队列研究，对象为16,000名原发于HL的人，其中包括4000人 受试者从南加州(圣地亚哥)招募。俄勒冈州猝死研究(SODS)是一项 以社区为基础的评估持续了16年(也是由PI创立的)。我们打算做一件 Presto HL SCA病例与圣地亚哥HCHS/SOL病例的比较； 在Presto nhw SCA案例和洛杉矶数据存储库(LADR)nhw控制之间。AS 最后一步，我们将尝试在单独的俄勒冈州肥皂剧中验证我们来自上述分析的发现，即 提供对HL亚群(约76%墨西哥血统)、NHW和所有相同信息的访问。考虑到缺乏 关于HL SCA的流行病学数据，以及HL和NHW在临床特征上的重要差异 在我们的先导研究中发现的SCA病例，应评估特定种族的SCA风险预测。而我们的 结果可能并不适用于所有美国HL人群，我们相信我们的研究将提供有价值的数据 主要来自墨西哥的霍奇金淋巴瘤。利用Ventura Presto的既定记录和资源， HCHS/SOL和俄勒冈州SODS使实现这一目标的可能性最大化。

Project Description Sudden cardiac arrest (SCA), a sudden catastrophic loss of the pulse, affects >350,000 in the US annually with a >90% mortality rate. Therefore, improved primary prevention is a major priority. SCA burden is affected by race, socioeconomic status, and potentially ethnicity. Hispanics/Latinos (HL) are the largest and most rapidly growing US minority, but there are no prospective studies of SCA in this subgroup. We performed a 1-yr (2015) prospective pilot study of SCA among all residents of Ventura County, CA (PREdiction of Sudden death in mulTi-ethnic cOmmunities, PRESTO, founded by the PI), with a population distribution of 42.3% HL (>89% Mexican origin) and 48.7% non-Hispanic white (NHW). There were significant differences in the clinical profile of HL (n=71) vs. NHW (n=204). Our pilot data also indicated other unique aspects of SCA in HL, specifically related to women, and the role of obesity. The overall goal of this proposal is to identify ethnicity-specific targets for improved SCA prediction and prevention. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is an NIH-funded multi-center cohort study of 16,000 persons of HL origin including 4000 subjects recruited from southern CA (San Diego). The Oregon Sudden Unexpected Death Study (SUDS) is a community-based evaluation ongoing for >16 years (also founded by the PI). We propose to make comparisons between PRESTO HL SCA cases and San Diego HCHS/SOL subjects on the one hand; and between PRESTO NHW SCA cases and Los Angeles Data Repository (LADR) NHW controls, on the other. As a final step, we will attempt to validate our findings from the above analysis in the separate Oregon SUDS, that provides access to an HL subgroup (~76% Mexican origin), NHW and all the same information. Given the lack of epidemiologic data on HL SCA, as well as the important differences in clinical profile between HL and NHW SCA cases identified in our pilot study, ethnicity-specific SCA risk prediction should be evaluated. While our results may not be generalizable to all US HL populations, we believe our study would provide valuable data for HL of primarily Mexican origin. Leveraging the established track record and resources of Ventura PRESTO, HCHS/SOL and Oregon SUDS maximizes the likelihood of achieving this objective.