The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.

项目摘要/摘要 候选人。这位候选人是克里安健康与行为科学学院的助理教授，网址为 查普曼大学。到目前为止，她的研究表明，患有糖尿病的人的姿势协调发生了变化 下腰痛(LBP)和检查躯干预期姿势调整的神经相关性。她长长的- 长期目标是开发康复干预措施，以减少慢性LBP的发展。这个项目将 帮助她了解神经机械和心理因素对LBP的影响，并做好准备 她需要设计和进行大型纵向和临床试验。指导团队和培训计划。主要 导师劳拉·M·格林博士在进行前瞻性研究方面拥有丰富的经验。 对大脑和行为的生物、心理和社会影响。她提供纵向研究设计方面的专业知识和 多因素分析，以及职业发展指导。史蒂文·C·克雷默博士是一位 中枢神经系统恢复，他将就感觉运动系统的磁共振成像提供建议。 琳达·范·迪伦博士在腰痛患者的临床研究方面拥有丰富的经验。被指导的人 在她的实验室实习将提供管理R01资助的临床试验的直接经验。杰西·V博士 雅各布斯在姿势协调的神经机制方面拥有专业知识。Tain荣文博士将就 磁共振成像的技术方面和Babak ShahBaba博士将提供统计支持。这个 应聘者还将完成神经成像、多元数据分析和临床研究方面的教学培训。 环境应聘者在以下方面有大量的合作和学术发展机会 查普曼，并使用一个设备齐全的动作捕捉实验室。她可以接触到更多的知识分子 加州大学欧文分校的发展机遇和核磁共振扫描设施。研究。这个 LBP新发作率最高的时期发生在青壮年。这项研究的目的是 确定青年LBP复发/进展的神经机械危险因素。AIM 1将使用 肌电图法确定椎旁疲劳后躯干/骨盆姿势协调是否发生变化 在有LBP病史的无症状年轻人中，运动量比没有LBP病史的人更多。目标 2将确定年轻人的中枢感觉运动形态、连通性或活动性是否发生变化 有LBP病史的成年人，组间的连通性和激活差异是否较大 疲劳运动后的明显表现，以及这种大脑重组是否与姿势改变有关 协调。目标3将确定神经机械因素是否独立地与 LBP症状复发/进展超过18个月。

Project Summary/Abstract Candidate. The candidate is an Assistant Professor in Crean College of Health and Behavioral Sciences, at Chapman University. Her research to date has demonstrated altered postural coordination in individuals with low back pain (LBP) and examined neural correlates of anticipatory postural adjustments in the trunk. Her long- term goal is to develop rehabilitation interventions to reduce the development of chronic LBP. This project will help her to understand the influence of neuromechanical and psychological factors on LBP, and will prepare her to design and conduct large longitudinal and clinical trials. Mentorship team and training plan. Primary mentor, Dr. Laura M. Glynn, has extensive experience of conducting prospective studies investigating biopsychosocial influences on brain and behavior. She provides expertise in longitudinal study design and multifactorial analysis, as well as guidance on career development. Dr. Steven C. Cramer is an expert on central nervous system recovery who will advise on magnetic resonance imaging of the sensorimotor system. Dr. Linda Van Dillen has substantial experience in clinical research of individuals with LBP. A mentored practicum at her lab will provide direct experience of management of R01-funded clinical trials. Dr. Jesse V. Jacobs has expertise in neural mechanisms underlying postural coordination. Dr. Rongwen Tain will advise on technical aspects of magnetic resonance imaging and Dr. Babak Shahbaba will provide statistical support. The candidate will also complete didactic training in neuroimaging, multivariate data analysis, and clinical research. Environment. The candidate has substantial opportunities for collaboration and academic development at Chapman, and use of a fully equipped motion capture laboratory. She has access to additional intellectual development opportunities and MRI scanning facilities at University of California, Irvine. Research. The highest incidence of new episodes of LBP occurs during young adulthood. The objective of this study is to identify neuromechanical risk factors for recurrence/progression of LBP in young adults. Aim 1 will use electromyography to determine if changes in trunk/pelvis postural coordination following fatiguing paraspinal exercise are greater in asymptomatic young adults with a history of LBP than those with no history of LBP. Aim 2 will establish if there are alterations in central sensorimotor morphology, connectivity, or activity in young adults with a history of LBP, whether the connectivity and activation differences between groups are more evident following fatiguing exercise, and whether this brain reorganization is associated with altered postural coordination. Aim 3 will identify if neuromechanical factors are independently associated with recurrence/progression of LBP symptoms over 18 months.