The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.

项目总结/摘要 候选人候选人是健康和行为科学的克林学院的助理教授，在 查普曼大学。她迄今为止的研究表明， 下背痛（LBP）和检查躯干中预期姿势调整的神经相关性。她的长- 长期目标是制定康复干预措施，以减少慢性LBP的发展。该项目将 帮助她了解神经力学和心理因素对LBP的影响，并准备 她设计和进行大型纵向和临床试验。指导团队和培训计划。初级 导师劳拉·M博士Glynn在进行前瞻性研究方面具有丰富的经验， 对大脑和行为的生物心理社会影响。她提供纵向研究设计方面的专业知识， 多因素分析以及职业发展指导。史蒂文·C博士克莱默是一个专家， 中枢神经系统康复专家，他将对感觉运动系统的磁共振成像提供建议。 博士琳达货车狄伦在LBP个体的临床研究方面具有丰富的经验。一个指导 在她的实验室实习将提供R 01资助的临床试验管理的直接经验。杰西·V博士 雅各布斯在姿势协调的神经机制方面有专长。Dr. Rongwen Tain将提供以下建议： 此外，他还将负责磁共振成像技术方面的工作，Babak Shahbaba博士将提供统计支持。的 候选人还将完成神经影像学，多元数据分析和临床研究的教学培训。 环境候选人有大量的合作和学术发展的机会， 查普曼，并使用一个设备齐全的动作捕捉实验室。她可以接触到更多的知识分子 在加州大学欧文分校的发展机会和MRI扫描设施。Research.的 LBP的新发作的最高发生率发生在年轻的成年期。本研究的目的是 确定年轻人LBP复发/进展的神经力学危险因素。目标1将使用 肌电图检查，以确定脊柱旁疲劳后躯干/骨盆姿势协调是否发生变化 运动在有LBP病史的无症状年轻人中的作用大于无LBP病史的年轻人。目的 2将确定是否有改变，在中央感觉运动形态，连接，或活动在年轻的 有LBP病史的成年人，是否组间连接和激活差异更大 疲劳运动后明显，以及这种大脑重组是否与姿势改变有关。 协同目标3将确定神经力学因素是否与 LBP症状复发/进展超过18个月。

Project Summary/Abstract Candidate. The candidate is an Assistant Professor in Crean College of Health and Behavioral Sciences, at Chapman University. Her research to date has demonstrated altered postural coordination in individuals with low back pain (LBP) and examined neural correlates of anticipatory postural adjustments in the trunk. Her long- term goal is to develop rehabilitation interventions to reduce the development of chronic LBP. This project will help her to understand the influence of neuromechanical and psychological factors on LBP, and will prepare her to design and conduct large longitudinal and clinical trials. Mentorship team and training plan. Primary mentor, Dr. Laura M. Glynn, has extensive experience of conducting prospective studies investigating biopsychosocial influences on brain and behavior. She provides expertise in longitudinal study design and multifactorial analysis, as well as guidance on career development. Dr. Steven C. Cramer is an expert on central nervous system recovery who will advise on magnetic resonance imaging of the sensorimotor system. Dr. Linda Van Dillen has substantial experience in clinical research of individuals with LBP. A mentored practicum at her lab will provide direct experience of management of R01-funded clinical trials. Dr. Jesse V. Jacobs has expertise in neural mechanisms underlying postural coordination. Dr. Rongwen Tain will advise on technical aspects of magnetic resonance imaging and Dr. Babak Shahbaba will provide statistical support. The candidate will also complete didactic training in neuroimaging, multivariate data analysis, and clinical research. Environment. The candidate has substantial opportunities for collaboration and academic development at Chapman, and use of a fully equipped motion capture laboratory. She has access to additional intellectual development opportunities and MRI scanning facilities at University of California, Irvine. Research. The highest incidence of new episodes of LBP occurs during young adulthood. The objective of this study is to identify neuromechanical risk factors for recurrence/progression of LBP in young adults. Aim 1 will use electromyography to determine if changes in trunk/pelvis postural coordination following fatiguing paraspinal exercise are greater in asymptomatic young adults with a history of LBP than those with no history of LBP. Aim 2 will establish if there are alterations in central sensorimotor morphology, connectivity, or activity in young adults with a history of LBP, whether the connectivity and activation differences between groups are more evident following fatiguing exercise, and whether this brain reorganization is associated with altered postural coordination. Aim 3 will identify if neuromechanical factors are independently associated with recurrence/progression of LBP symptoms over 18 months.