Targeting Ligands for autonomic uptake and drug delivery to the brain and spinal cord
Targeting Ligands for autonomic uptake and drug delivery to the brain and spinal cord
批准号:
9385694
负责人:
Drew L Sellers
金额:
$19.36万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-05-01 至 2019-04-30
关键词:
Alzheimer&aposs DiseaseAmyotrophic Lateral SclerosisAnatomyAutonomic nervous systemAxonBacteriophagesBiodistributionBloodBlood - brain barrier anatomyBrainBrain DiseasesBreathingCaringCentral Nervous System AgentsComplexConsensus SequenceCoupledCouplingDNA sequencingDataDevelopmentDiagnosisDiseaseDoseDrug Delivery SystemsDrug TargetingEngineeringFrequenciesFundingFutureGoalsGreater sac of peritoneumHarvestHeartHerpes Simplex InfectionsHumanImmunofluorescence ImmunologicIntramuscularIntramuscular InjectionsIntraperitoneal InjectionsKnowledgeLibrariesLigandsMethodologyModelingNanotechnologyNatureNeuraxisNeurodegenerative DisordersNeuronsNucleic AcidsOrganParkinson DiseasePeptidesPeriodicityPeripheralPeripheral NervesPeritonealPhage DisplayPharmaceutical PreparationsPropertyProteinsRecombinantsRouteSpinal CordSpinal DiseasesTechnologyTestingTissuesTranslatingVirusWorkbasecostdrug developmenthigh throughput analysisin vivoinnovationintraperitonealmad itch virusnext generationnext generation sequencingnovel drug classprotein aminoacid sequenceretrograde transportscreeningtargeted agenttargeted deliverytherapeutic developmenttherapy developmentuptake
中文摘要
项目总结
英文摘要
Project Summary
Worldwide, over 40 million people have been diagnosed with a neurodegenerative disease, such as
amyotrophic lateral sclerosis (ALS), Parkinson's Disease, or Alzheimer's Disease. Yet, with an annual cost-of-
care greater than $226 billion, there have yet to be effective drugs and delivery strategies developed to treat
these diseases. The overall goal of this project is to develop technologies that target uptake and delivery, via
the autonomic nervous system, of biologics (e.g. proteins, peptides, or nucleic acid drugs) to the central
nervous system (CNS). Since the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) protect the
CNS from drug-delivery, potential therapies for these neurodegenerative diseases have not been realized, in
part, due to the lack of delivery technologies. We base our approach on the knowledge that viruses are able to
target neurons in the periphery to facilitate uptake and retrograde transport into the CNS. We will screen a
recombinant phage display library for uptake and delivery to the brain and spinal cord after intraperitoneal (IP)
injection. Next-generation DNA sequencing (NGS) analysis will be used to analyze tissues for high-frequency
clones that transport into the CNS. We hypothesize that coupling an in vivo phage display screen with NGS will
enable an empiric, high-throughput analysis of consensus sequences to engineer a targeting ligand for delivery
to the CNS. In this work, we will optimize peptide ligands and evaluate these peptides in vivo for their ability to
enhance protein-drug accumulation in the brain and spinal cord after IP injection.
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会议论文
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders
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批准号:10400872
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项目类别:
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资助金额:$36.54万
-
财政年份:2020
-
负责人:Drew L Sellers
-
依托单位:
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders
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批准号:10029634
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项目类别:
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资助金额:$36.54万
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财政年份:2020
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负责人:Drew L Sellers
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依托单位:
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders
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批准号:10178139
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项目类别:
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资助金额:$36.54万
-
财政年份:2020
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负责人:Drew L Sellers
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依托单位:
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders
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批准号:10617204
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项目类别:
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资助金额:$36.54万
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财政年份:2020
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负责人:Drew L Sellers
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依托单位:
国内基金
海外基金
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批准号:81000622
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项目类别:青年科学基金项目
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依托单位:
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负责人:郭亚芬
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依托单位:
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负责人:董贵成
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依托单位: