Training in Parasitology and Vector Biology

寄生虫学和媒介生物学培训

• 批准号: 9390128
• 负责人: CHRISTIAN TSCHUDI
• 金额: $ 0.3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9390128
• 关键词: Biology; Parasitology; Training; vector

DESCRIPTION (provided by applicant): This application is a request for continued support of a predoctoral and postdoctoral training program in parasitology and vector biology at Yale University. Since its inception in 1991, the goal of the program has been to provide trainees with both a strong intellectual foundation through coursework and rigorous experimental training in areas that take molecular, cellular, immunological, epidemiological and ecological approaches to the study of pathogens and their vectors. To achieve this goal, the philosophy of the program is to bring together all faculty at Yale interested and actively researching helminths and vector-borne diseases (21 faculty in total). Consequently, trainees have the unique opportunity to study a number of vector-borne diseases from both a parasite and vector perspective, including Malaria, African sleeping sickness, leishmaniasis, West Nile virus, human ehrlichiosis and Lyme disease. This campus-wide platform provides the richest and broadest possible training environment for our graduate students and postdoctoral fellows and fosters connections that transcend departmental boundaries. Indeed, the training faculty has a strong history of working together collaboratively in research and teaching. A second distinctive aspect of the training program is the opportunity for graduate students and postdoctoral fellows to work with scientists from endemic countries and receive training in Africa, Asia and South America through funded research programs and ongoing collaborative projects. The majority of former trainees in the program are pursuing a career directly related to research or education in public health, medical or biological fields. Finally, Yale has made substantial commitments to training in parasitology and vector biology by providing first-year support to incoming students, by renovating extensive research space for training faculty and through hiring of new faculty, as well as promotions of current program faculty at the junior and senior levels.

描述（由申请人提供）：本申请是对耶鲁大学寄生虫学和媒介生物学博士前和博士后培训项目的持续支持的请求。自 1991 年启动以来，该项目的目标一直是通过课程作业和严格的实验培训为学员提供坚实的智力基础，这些领域采用分子、细胞、免疫学、流行病学和生态学方法来研究病原体及其载体。为了实现这一目标，该项目的理念是将耶鲁大学所有对蠕虫和媒介传播疾病感兴趣并积极研究的教师聚集在一起（总共 21 名教师）。因此，学员有独特的机会从寄生虫和媒介的角度研究许多媒介传播的疾病，包括疟疾、非洲昏睡病、利什曼病、西尼罗河病毒、人类埃利希体病和莱姆病。这个校园范围的平台为我们的研究生和博士后研究员提供了最丰富和最广泛的培训环境，并促进超越部门界限的联系。事实上，培训教师在研究和教学方面有着悠久的合作历史。培训计划的第二个独特方面是研究生和博士后研究员有机会与来自流行国家的科学家合作，并通过资助的研究计划和正在进行的合作项目在非洲、亚洲和南美洲接受培训。该计划的大多数前学员正在从事与公共卫生、医学或生物领域的研究或教育直接相关的职业。最后，耶鲁大学对寄生虫学和媒介生物学的培训作出了重大承诺，为新生提供第一年的支持，为培训教师翻新广泛的研究空间，聘用新教师，以及晋升初级和高级的现有项目教师。

项目成果

Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya.

肯尼亚南部舌蝇采采蝇的遗传分化。

• DOI: 10.4269/ajtmh.18-0154
• 发表时间: 2018
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Okeyo,WinnieA;Saarman,NorahP;Bateta,Rosemary;Dion,Kirstin;Mengual,Michael;Mireji,PaulO;Ouma,Collins;Okoth,Sylvance;Murilla,Grace;Aksoy,Serap;Caccone,Adalgisa
• 通讯作者: Caccone,Adalgisa

Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection.

全基因组测序显示昏睡病复发是由于寄生虫重新生长而不是再次感染造成的。

• DOI: 10.1111/eva.12338
• 发表时间: 2016
• 期刊: Evolutionary applications
• 影响因子: 4.1
• 作者: Richardson,JoshuaB;Evans,Benjamin;Pyana,PatientP;VanReet,Nick;Sistrom,Mark;Büscher,Philippe;Aksoy,Serap;Caccone,Adalgisa
• 通讯作者: Caccone,Adalgisa

Urban slum structure: integrating socioeconomic and land cover data to model slum evolution in Salvador, Brazil.

• DOI: 10.1186/1476-072x-12-45
• 发表时间: 2013-10-20
• 期刊: International journal of health geographics
• 影响因子: 4.9
• 作者: Hacker KP;Seto KC;Costa F;Corburn J;Reis MG;Ko AI;Diuk-Wasser MA
• 通讯作者: Diuk-Wasser MA

Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells.

• DOI: 10.1371/journal.pone.0055584
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: van de Hoef DL;Coppens I;Holowka T;Ben Mamoun C;Branch O;Rodriguez A
• 通讯作者: Rodriguez A

The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.

• DOI: 10.4049/jimmunol.1400728
• 发表时间: 2014-09-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Ehrlich A;Castilho TM;Goldsmith-Pestana K;Chae WJ;Bothwell AL;Sparwasser T;McMahon-Pratt D
• 通讯作者: McMahon-Pratt D