MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY

操纵树突状细胞代谢以促进癌症免疫

基本信息

  • 批准号:
    9067234
  • 负责人:
  • 金额:
    $ 23.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-04-01 至 2017-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): We are interested in manipulating the biology of dendritic cells (DCs) in order to enhance or inhibit their ability to induce T cell immunity, which underpins both protective and sometimes deleterious (as is the case in autoimmunity or asthma, for example) immune responses. DCs stand at the interface between innate and adaptive immunity. They express receptors (such as Toll-like receptors, TLRs) that allow them to sense and respond to infection. Following exposure to TLR agonists, which typically are pathogen-derived, quiescent DCs become activated through a process that encompasses changes in expression of genes including those that initiate inflammation and allow DCs to activate naive T cells and thereby stimulate adaptive immune responses. The impact of activated DCs, which is potentially dangerous, is tightly regulated by cytokines such as IL-10, and by a poorly understood mechanism through which cellular lifespan is limited following exposure to TLR agonists. It is increasingly clear that changes in cellular longevity and activation are coupled to profound changes in metabolism. Consistent with this, we have found that the transition of mouse bone marrow-derived DCs from quiescent to activated states involves a significant and prolonged upregulation of aerobic glycolysis and a concomitant decrease in mitochondrial oxidative phosphorylation. Importantly, depriving DCs of glucose or promoting mitochondrial metabolism inhibits activation, suggesting that glycolysis is permissive for DC activation whereas mitochondrial metabolism is not. Collectively, our data implicate DC metabolic reprogramming as an integral component of the activation process. However, we have yet to experimentally address why activation requires such a metabolic switch, or why cellular lifespan is shortened once this switch has occurred, or whether the observed metabolic changes occur in mouse DCs that develop in vivo, or in human DCs. Based on our published and preliminary data, we hypothesize that either: 1) glycolysis is the only type of metabolism that can support the demands of activation, or 2) activated DCs switch to glycolysis because mitochondrial metabolism shuts down as a result of activation. We plan to explore these possibilities in detail through the following specific aims: 1) To determine why TLR-mediated activation of DCs is accompanied by a switch to glycolysis; 2) To explore the role of mitochondrial function and AMP-kinase in DC activation and survival; 3) To promote DC lifespan and sustained expression of costimulatory molecules through the manipulation of metabolic pathways. Our long term goal is to be able to manipulate metabolic processes in DCs in order to promote or inhibit their activation and/or longevity, and in so doing develop novel approaches for improving vaccination strategies, and limiting immune responses in chronic, pathological conditions.
描述(由申请人提供):我们对操纵树突状细胞(dc)的生物学以增强或抑制其诱导T细胞免疫的能力感兴趣

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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EDWARD J. PEARCE其他文献

Schistosomiasis vaccine
血吸虫病疫苗
  • DOI:
    10.1038/334478b0
  • 发表时间:
    1988-08-01
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    ALAN SHER;EDWARD J. PEARCE
  • 通讯作者:
    EDWARD J. PEARCE

EDWARD J. PEARCE的其他文献

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{{ truncateString('EDWARD J. PEARCE', 18)}}的其他基金

Stromal cells in immunity to infection
基质细胞对感染具有免疫力
  • 批准号:
    10711890
  • 财政年份:
    2023
  • 资助金额:
    $ 23.94万
  • 项目类别:
MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY
操纵树突状细胞代谢以促进癌症免疫
  • 批准号:
    9133018
  • 财政年份:
    2016
  • 资助金额:
    $ 23.94万
  • 项目类别:
MACROPHAGE FATTY ACID METABOLISM IN IMMUNITY TO HELMINTHS
蠕虫免疫中的巨噬细胞脂肪酸代谢
  • 批准号:
    9187865
  • 财政年份:
    2015
  • 资助金额:
    $ 23.94万
  • 项目类别:
MACROPHAGE FATTY ACID METABOLISM IN IMMUNITY TO HELMINTHS
蠕虫免疫中的巨噬细胞脂肪酸代谢
  • 批准号:
    8887045
  • 财政年份:
    2015
  • 资助金额:
    $ 23.94万
  • 项目类别:
MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY
操纵树突状细胞代谢以促进癌症免疫
  • 批准号:
    8843386
  • 财政年份:
    2012
  • 资助金额:
    $ 23.94万
  • 项目类别:
MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY
操纵树突状细胞代谢以促进癌症免疫
  • 批准号:
    8370766
  • 财政年份:
    2012
  • 资助金额:
    $ 23.94万
  • 项目类别:
MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY
操纵树突状细胞代谢以促进癌症免疫
  • 批准号:
    8677812
  • 财政年份:
    2012
  • 资助金额:
    $ 23.94万
  • 项目类别:
MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITY
操纵树突状细胞代谢以促进癌症免疫
  • 批准号:
    8519388
  • 财政年份:
    2012
  • 资助金额:
    $ 23.94万
  • 项目类别:
Schistosome egg induced Th2 responses
血吸虫卵诱导Th2反应
  • 批准号:
    8239542
  • 财政年份:
    2011
  • 资助金额:
    $ 23.94万
  • 项目类别:
Schistosome egg induced Th2 responses
血吸虫卵诱导 Th2 反应
  • 批准号:
    8368082
  • 财政年份:
    2011
  • 资助金额:
    $ 23.94万
  • 项目类别:

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